Organism : Bacillus cereus ATCC14579 | Module List :
BC0414

PTS system, glucose-specific IIBC component (NCBI ptt file)

CircVis
Functional Annotations (10)
Function System
Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific cog/ cog
sugar:hydrogen symporter activity go/ molecular_function
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity go/ molecular_function
protein-N(PI)-phosphohistidine-sugar phosphotransferase complex go/ cellular_component
phosphoenolpyruvate-dependent sugar phosphotransferase system go/ biological_process
membrane go/ cellular_component
Glycolysis / Gluconeogenesis kegg/ kegg pathway
Amino sugar and nucleotide sugar metabolism kegg/ kegg pathway
Phosphotransferase system (PTS) kegg/ kegg pathway
EIIB_glc tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC0414
(Mouseover regulator name to see its description)

BC0414 is regulated by 28 influences and regulates 0 modules.
Regulators for BC0414 (28)
Regulator Module Operator
BC0410 387 tf
BC0613 387 tf
BC0659 387 tf
BC1083 387 tf
BC1335 387 tf
BC2469 387 tf
BC2794 387 tf
BC4433 387 tf
BC4474 387 tf
BC4570 387 tf
BC4611 387 tf
BC4960 387 tf
BC0057 454 tf
BC0114 454 tf
BC0953 454 tf
BC1115 454 tf
BC1329 454 tf
BC2410 454 tf
BC2469 454 tf
BC2517 454 tf
BC2811 454 tf
BC3025 454 tf
BC3408 454 tf
BC3449 454 tf
BC3587 454 tf
BC3961 454 tf
BC4611 454 tf
BC5251 454 tf

Warning: BC0414 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4684 3.00e-23 tAtGAAAaCGcTtaCa
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4685 5.90e-06 aggGtGGA
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4818 5.60e-07 aaggaGggGaataa
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4819 2.60e+01 aCAttcCcctTg
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC0414

BC0414 is enriched for 10 functions in 3 categories.
Module neighborhood information for BC0414

BC0414 has total of 54 gene neighbors in modules 387, 454
Gene neighbors (54)
Gene Common Name Description Module membership
BC0338 BC0338 hypothetical protein (NCBI ptt file) 387, 391
BC0378 BC0378 5-methylthioribose kinase (NCBI ptt file) 387, 516
BC0380 BC0380 L-fuculose phosphate aldolase (NCBI ptt file) 387, 516
BC0414 BC0414 PTS system, glucose-specific IIBC component (NCBI ptt file) 387, 454
BC0415 BC0415 Exodeoxyribonuclease III (NCBI ptt file) 387, 454
BC0462 BC0462 Calcium/proton antiporter (NCBI ptt file) 42, 454
BC0592 BC0592 Alanine dehydrogenase (NCBI ptt file) 234, 387
BC0631 BC0631 PTS system, trehalose-specific IIBC component (NCBI ptt file) 283, 387
BC0632 BC0632 Trehalose-6-phosphate hydrolase (NCBI ptt file) 283, 387
BC0655 BC0655 Universal stress protein family (NCBI ptt file) 212, 454
BC0774 BC0774 Sucrose-6-phosphate hydrolase (NCBI ptt file) 387, 478
BC0775 BC0775 PTS system, sucrose-specific IIBC component (NCBI ptt file) 387, 478
BC0807 BC0807 PTS system, diacetylchitobiose-specific IIA component (NCBI ptt file) 234, 387
BC0808 BC0808 PTS system, diacetylchitobiose-specific IIB component (NCBI ptt file) 387, 516
BC0809 BC0809 PTS system, diacetylchitobiose-specific IIC component (NCBI ptt file) 199, 387
BC0841 BC0841 Glucokinase regulatory protein (NCBI ptt file) 80, 387
BC0842 BC0842 PTS system, sucrose-specific IIBC component (NCBI ptt file) 387, 454
BC0843 BC0843 outer surface protein (NCBI ptt file) 80, 387
BC0952 BC0952 hypothetical protein (NCBI ptt file) 316, 454
BC0953 BC0953 Transcriptional regulator, MerR family (NCBI ptt file) 364, 454
BC0963 BC0963 hypothetical protein (NCBI ptt file) 160, 454
BC0983 BC0983 hypothetical protein (NCBI ptt file) 153, 454
BC1083 BC1083 Transcriptional regulator, LacI family (NCBI ptt file) 387, 516
BC1185 BC1185 Oligopeptide-binding protein oppA (NCBI ptt file) 199, 387
BC1388 BC1388 hypothetical protein (NCBI ptt file) 97, 454
BC1440 BC1440 hypothetical protein (NCBI ptt file) 80, 387
BC1442 BC1442 hypothetical protein (NCBI ptt file) 248, 454
BC1600 BC1600 Ribonuclease H (NCBI ptt file) 454, 489
BC2238 BC2238 hypothetical protein (NCBI ptt file) 387, 516
BC2274 BC2274 hypothetical protein (NCBI ptt file) 160, 454
BC2518 BC2518 Methyltransferase (NCBI ptt file) 248, 454
BC2747 BC2747 hypothetical Cytosolic Protein (NCBI ptt file) 238, 454
BC2825 BC2825 hypothetical protein (NCBI ptt file) 248, 454
BC3328 BC3328 ABC transporter permease protein (NCBI ptt file) 363, 454
BC3330 BC3330 hypothetical protein (NCBI ptt file) 454, 497
BC3350 BC3350 TPR-repeat-containing protein (NCBI ptt file) 160, 454
BC3408 BC3408 Transcriptional regulator, MarR family (NCBI ptt file) 454, 489
BC3433 BC3433 hypothetical protein (NCBI ptt file) 267, 454
BC3449 BC3449 Catabolite gene activator (NCBI ptt file) 454, 489
BC3451 BC3451 hypothetical Membrane Spanning Protein (NCBI ptt file) 454, 496
BC3718 BC3718 PTS system, fructose-specific IIABC component (NCBI ptt file) 387, 516
BC4012 BC4012 Cyclodextrin transport system permease protein (NCBI ptt file) 111, 454
BC4025 BC4025 hypothetical protein (NCBI ptt file) 167, 454
BC4526 BC4526 acyl-CoA synthase (RefSeq) 358, 387
BC4622 BC4622 hypothetical protein (NCBI ptt file) 316, 454
BC4713 BC4713 hypothetical protein (NCBI ptt file) 227, 454
BC4814 BC4814 hypothetical protein (NCBI ptt file) 234, 387
BC4843 BC4843 2-dehydro-3-deoxygluconokinase (NCBI ptt file) 387, 516
BC4844 BC4844 4-Hydroxy-2-oxoglutarate aldolase (NCBI ptt file) 387, 516
BC4845 BC4845 L-seryl-tRNA(Sec) selenium transferase (NCBI ptt file) 387, 516
BC4846 BC4846 Dihydroorotase (NCBI ptt file) 387, 516
BC5211 BC5211 PTS system, lichenan oligosaccharide-specific IIC component (NCBI ptt file) 387, 516
BC5228 BC5228 L-lactate permease (NCBI ptt file) 387, 516
BC5286 BC5286 Transcriptional regulator with ABC transporter ATP-binding domain and LytTR DNA-binding domain (NCBI ptt file) 411, 454
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC0414
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend