Organism : Bacillus subtilis | Module List :
BSU30340 ytvA

blue light GTP-binding receptor (RefSeq)

CircVis
Functional Annotations (5)
Function System
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) cog/ cog
two-component sensor activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
regulation of transcription, DNA-dependent go/ biological_process
sensory_box tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU30340
(Mouseover regulator name to see its description)

BSU30340 is regulated by 20 influences and regulates 0 modules.
Regulators for BSU30340 ytvA (20)
Regulator Module Operator
BSU00830 82 tf
BSU04680 82 tf
BSU09560 82 tf
BSU13760 82 tf
BSU24020 82 tf
BSU27110 82 tf
BSU31530 82 tf
BSU36020 82 tf
BSU03880 373 tf
BSU05270 373 tf
BSU09430 373 tf
BSU13150 373 tf
BSU13760 373 tf
BSU16600 373 tf
BSU19120 373 tf
BSU19540 373 tf
BSU24020 373 tf
BSU30020 373 tf
BSU31530 373 tf
BSU36020 373 tf

Warning: BSU30340 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5118 8.50e-03 AaAaAGggGAa
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5119 3.90e+01 aGGAGG
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5662 3.00e+01 CCTatATATTtcaTtGAAAgG
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5663 5.70e+02 GATCATcATaCCaAA
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU30340

BSU30340 is enriched for 5 functions in 3 categories.
Module neighborhood information for BSU30340

BSU30340 has total of 44 gene neighbors in modules 82, 373
Gene neighbors (44)
Gene Common Name Description Module membership
BSU00670 tilS tRNAile lysidine synthetase (RefSeq) 82, 354
BSU04550 ydbP putative thioredoxin or thiol-disulfide isomerase (RefSeq) 123, 373
BSU04790 ydcK hypothetical protein (RefSeq) 82, 354
BSU05260 ydeN alpha/beta hydrolase (RefSeq) 373, 381
BSU05400 ydfG hypothetical protein (RefSeq) 373, 381
BSU05760 ydhH hypothetical protein (RefSeq) 373, 381
BSU05770 ydhI putative acetyltransferase (RefSeq) 373, 381
BSU05950 ydiF putative ABC transporter (ATP-binding protein) (RefSeq) 123, 373
BSU07680 yflH hypothetical protein (RefSeq) 262, 373
BSU07690 yflG methionine aminopeptidase (RefSeq) 82, 354
BSU08620 yfhP putative membrane hydrolase (RefSeq) 82, 354
BSU09980 yhaI hypothetical protein (RefSeq) 373, 381
BSU10800 yizA hypothetical protein (RefSeq) 310, 373
BSU11520 mecA adaptor protein (RefSeq) 82, 354
BSU11550 yjbH putative thiol management oxidoreductase component (RefSeq) 82, 109
BSU11560 yjbI putative thiol management oxidoreductase component (RefSeq) 82, 354
BSU13030 ykhA putative acyl-CoA hydrolase (RefSeq) 77, 82
BSU13540 ogt O6-alkylguanine DNA alkyltransferase (RefSeq) 373, 381
BSU14560 def peptide deformylase (RefSeq) 91, 373
BSU19470 yojF hypothetical protein (RefSeq) 82, 354
BSU19680 yozE hypothetical protein (RefSeq) 373, 381
BSU21680 yppQ methionine sulfoxide reductase B (RefSeq) 249, 373
BSU21690 msrA methionine sulfoxide reductase A (RefSeq) 249, 373
BSU22950 ypdA putative FAD-dependent disulfide oxidoreductase (RefSeq) 82, 402
BSU23630 yqkE hypothetical protein (RefSeq) 109, 373
BSU23640 yqkD putative hydrolase (RefSeq) 111, 373
BSU23650 yqkC hypothetical protein (RefSeq) 51, 82
BSU23660 yqkB hypothetical protein (RefSeq) 82, 354
BSU24010 bmr multidrug-efflux transporter (RefSeq) 82, 354
BSU24020 bmrR transcriptional regulator (MerR family) (RefSeq) 82, 354
BSU29640 ytsP hypothetical protein (RefSeq) 82, 262
BSU30340 ytvA blue light GTP-binding receptor (RefSeq) 82, 373
BSU31030 yuaE hypothetical protein (RefSeq) 373, 381
BSU31520 yufL sensory histidine kinase DcuS (RefSeq) 82, 354
BSU31530 yufM two-component response regulator [YufL] (RefSeq) 82, 354
BSU31820 yuzF hypothetical protein (RefSeq) 82, 354
BSU31830 yueE putative metal-dependent phosphohydrolase (RefSeq) 82, 354
BSU33520 csoR repressor of copper utilisation proteins (RefSeq) 82, 354
BSU37520 ywhD hypothetical protein (RefSeq) 82, 237
BSU37530 ywhC putative metal-dependent hydrolase; integral inner membrane protein (RefSeq) 82, 237
BSU38020 thiD pyridoxal kinase (RefSeq) 82, 160
BSU39790 yxcE hypothetical protein (RefSeq) 109, 373
BSU39800 yxcD hypothetical protein (RefSeq) 109, 373
BSU40790 yyaO hypothetical protein (RefSeq) 373, 381
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU30340
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend