Organism : Bacillus subtilis | Module List :
BSU32760 yusD

hypothetical protein (RefSeq)

CircVis
Functional Annotations (1)
Function System
sterol binding go/ molecular_function
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU32760
(Mouseover regulator name to see its description)

BSU32760 is regulated by 21 influences and regulates 0 modules.
Regulators for BSU32760 yusD (21)
Regulator Module Operator
BSU05180 49 tf
BSU05390 49 tf
BSU05850 49 tf
BSU09430 49 tf
BSU10560 49 tf
BSU25810 49 tf
BSU33660 49 tf
BSU33680 49 tf
BSU36160 49 tf
BSU05130 404 tf
BSU05850 404 tf
BSU09270 404 tf
BSU09650 404 tf
BSU10560 404 tf
BSU10860 404 tf
BSU24220 404 tf
BSU24610 404 tf
BSU29270 404 tf
BSU35050 404 tf
BSU35110 404 tf
BSU35490 404 tf

Warning: BSU32760 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5056 1.40e-04 Ac.TTtTT.AgGAAgGGaAgg
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5057 2.60e+02 Tga.catagaaaaAcaGGttaaGA
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5716 9.60e-02 tAtaaTtAaaa.AtAgGgagatgg
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5717 2.70e+03 CCGGaCtGgCT
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU32760

BSU32760 is enriched for 1 functions in 2 categories.
Enrichment Table (1)
Function System
sterol binding go/ molecular_function
Module neighborhood information for BSU32760

BSU32760 has total of 56 gene neighbors in modules 49, 404
Gene neighbors (56)
Gene Common Name Description Module membership
BSU02650 pcp pyrrolidone-carboxylate peptidase (RefSeq) 208, 404
BSU03540 ycxB hypothetical protein (RefSeq) 49, 115
BSU03660 yclE putative hydrolase (RefSeq) 208, 404
BSU04480 ydbI putative integral inner membrane protein (RefSeq) 208, 404
BSU05110 ydeA putative enzyme (RefSeq) 49, 115
BSU05130 ydeB putative transcriptional regulator (RefSeq) 91, 404
BSU05630 dinB nuclease inhibitor (RefSeq) 49, 114
BSU07860 yfkL efflux transporter (RefSeq) 49, 219
BSU07870 yfkK hypothetical protein (RefSeq) 49, 274
BSU08720 ygaF putative bacterioferritin comigratory protein; putative peroxiredoxin (RefSeq) 222, 404
BSU08740 ygzB hypothetical protein (RefSeq) 22, 404
BSU08820 katA vegetative catalase 1 (RefSeq) 49, 237
BSU09260 yhxA aminotransferase (RefSeq) 330, 404
BSU09270 glpP glycerol-3-phosphate responding transcription antiterminator (RefSeq) 208, 404
BSU09540 plsC 1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase (RefSeq) 64, 404
BSU09650 yhdZ NAD-dependent deacetylase (RefSeq) 208, 404
BSU10440 yhjA hypothetical protein (RefSeq) 208, 404
BSU10550 ntdA biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose); aminotransferase (RefSeq) 49, 379
BSU10560 yhjM transcriptional regulator of the ntd operon; (LacI family) (RefSeq) 49, 91
BSU12040 yjdG putative acetyltransferase (RefSeq) 49, 159
BSU12060 yjdI hypothetical protein (RefSeq) 49, 216
BSU12100 yjeA secreted deoxyriboendonuclease (RefSeq) 49, 51
BSU12450 yjpA putative enzyme (RefSeq) 25, 404
BSU14510 ktrC potassium uptake protein (RefSeq) 310, 404
BSU14940 ylbA hypothetical protein (RefSeq) 25, 404
BSU17020 ymcA master regulator for biofilm formation (RefSeq) 208, 404
BSU21830 ypjQ putative phosphatidylglycerophosphatase (RefSeq) 64, 404
BSU23520 fur transcriptional regulator for iron transport and metabolism (RefSeq) 49, 249
BSU24110 yqzF hypothetical protein (RefSeq) 208, 404
BSU24220 spo0A response regulator (RefSeq) 208, 404
BSU24490 yqhQ hypothetical protein (RefSeq) 208, 404
BSU24500 yqhP hypothetical protein (RefSeq) 208, 404
BSU24610 sinR transcriptional regulator for post-exponential-phase response (RefSeq) 219, 404
BSU24800 yqgW hypothetical protein (RefSeq) 25, 404
BSU25770 spoIVCA site-specific DNA recombinase (RefSeq) 49, 217
BSU25790 arsB arsenite efflux transporter (RefSeq) 49, 249
BSU25800 yqcK putative thiol lyase (RefSeq) 49, 249
BSU25810 arsR transcriptional regulator (ArsR family) (RefSeq) 49, 249
BSU26780 yrdA hypothetical protein (RefSeq) 304, 404
BSU26790 aadK aminoglycoside 6-adenylyltransferase (RefSeq) 94, 404
BSU26900 yraL hypothetical protein (RefSeq) 208, 404
BSU26920 yraJ hypothetical protein (RefSeq) 208, 404
BSU26930 yraI hypothetical protein (RefSeq) 208, 404
BSU27190 yrzI hypothetical protein (RefSeq) 49, 157
BSU29270 ytoI hypothetical protein (RefSeq) 206, 404
BSU30670 luxS S-ribosylhomocysteinase (RefSeq) 49, 64
BSU30690 ytiB carbonic anhydrase (RefSeq) 49, 105
BSU32760 yusD hypothetical protein (RefSeq) 49, 404
BSU33120 liaH modulator of liaIHGFSR (yvqIHGFEC) operon expression (RefSeq) 19, 49
BSU33650 yvzC putative transcriptional regulator (RefSeq) 49, 71
BSU33660 rghRA transcriptional repressor (RefSeq) 49, 258
BSU33670 rghRB putative transcriptional repressor (RefSeq) 49, 258
BSU33680 yvaP putative transcriptional regulator (RefSeq) 49, 258
BSU34660 yvdB putative anion transporter (RefSeq) 208, 404
BSU35490 degU two-component response regulator (RefSeq) 208, 404
BSU36160 ywqM putative transcriptional regulator (LysR family) (RefSeq) 49, 216
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU32760
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend