Organism : Bacillus subtilis
| Module List :
BSU39510 yxeL
putative acetyltransferase (RefSeq)
Functional Annotations (2)
| Function | System |
|---|---|
| N-acetyltransferase activity | go/ molecular_function |
| metabolic process | go/ biological_process |
Module member 
Regulator 
Motif
Regulation information for BSU39510
(Mouseover regulator name to see its description)
| Regulator | Module | Operator |
|---|---|---|
| BSU00330 | 276 | tf |
| BSU03960 | 276 | tf |
| BSU04250 | 276 | tf |
| BSU13450 | 276 | tf |
| BSU34220 | 276 | tf |
| BSU34380 | 276 | tf |
| BSU03170 | 80 | tf |
| BSU13450 | 80 | tf |
| BSU24020 | 80 | tf |
| BSU27320 | 80 | tf |
| BSU28820 | 80 | tf |
| BSU29400 | 80 | tf |
| BSU30020 | 80 | tf |
| BSU40870 | 80 | tf |
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
| Motif Id | e-value | Consensus | Motif Logo |
|---|---|---|---|
| 5114 | 2.30e+03 | CGTcCAAGA |
 |
| 5115 | 5.10e+03 | TcCTtCtTTTt |
|
| 5490 | 2.80e+00 | agAT.atgtTctttaAt.agAgct |
|
| 5491 | 3.40e+03 | cgAAatCaGcCGcgG |
|
Functional Enrichment for BSU39510
| Function | System |
|---|---|
| N-acetyltransferase activity | go/ molecular_function |
| metabolic process | go/ biological_process |
Module neighborhood information for BSU39510
| Gene | Common Name | Description | Module membership |
|---|---|---|---|
| BSU00730 | cysK | cysteine synthase (RefSeq) | 80, 150 |
| BSU02520 | ycbJ | putative phosphotransferase (RefSeq) | 276, 302 |
| BSU03160 | ycgJ | putative methyltransferase (RefSeq) | 80, 341 |
| BSU03170 | ycgK | putative transcriptional regulator (LysR family) (RefSeq) | 80, 365 |
| BSU03180 | cah | S-deacylase (RefSeq) | 80, 261 |
| BSU03190 | ycgL | hypothetical protein (RefSeq) | 80, 185 |
| BSU03280 | nasF | uroporphyrin-III C-methyltransferase (RefSeq) | 80, 87 |
| BSU04140 | pbpC | penicillin-binding lipoprotein 3 (RefSeq) | 80, 245 |
| BSU04520 | ydbM | putative acyl-CoA dehydrogenase (RefSeq) | 80, 356 |
| BSU07200 | yetJ | putative integral inner membrane protein (RefSeq) | 60, 80 |
| BSU09130 | tcyP | sodium-cystine symporter (RefSeq) | 80, 190 |
| BSU10770 | wprA | cell wall-associated protease (RefSeq) | 125, 276 |
| BSU11980 | yjdA | 3-ketoacyl-(acyl-carrier-protein) reductase (RefSeq) | 23, 276 |
| BSU13140 | ohrA | peroxiredoxin (RefSeq) | 80, 365 |
| BSU16845 | BSU16845 | None | 80, 215 |
| BSU22040 | ypbQ | putative integral inner membrane enzyme (RefSeq) | 179, 276 |
| BSU22050 | bcsA | terpene family molecule synthase (RefSeq) | 179, 276 |
| BSU24620 | tasA | major biofilm matrix component (RefSeq) | 195, 276 |
| BSU24630 | sipW | type I signal peptidase (RefSeq) | 195, 276 |
| BSU24640 | yqxM | lipoprotein for biofilm formation (RefSeq) | 195, 276 |
| BSU27200 | yrhG | putative formate/nitrite transporter (RefSeq) | 80, 102 |
| BSU27250 | yrhB | cystathionine beta-lyase (RefSeq) | 80, 150 |
| BSU27260 | mccA | cystathionine beta-synthase for the reverse transsulfuration pathway (RefSeq) | 80, 150 |
| BSU31670 | yuxO | putative esterase (RefSeq) | 276, 334 |
| BSU32050 | yuiE | leucyl aminopeptidase (RefSeq) | 80, 255 |
| BSU34220 | epsO | putative pyruvyl transferase (RefSeq) | 195, 276 |
| BSU34230 | epsN | putative aminotransferase (RefSeq) | 195, 276 |
| BSU34240 | epsM | putative O-acetyltransferase (RefSeq) | 195, 276 |
| BSU34250 | epsL | putative phosphotransferase involved in extracellular matrix synthesis (RefSeq) | 195, 276 |
| BSU34280 | epsJ | putative glycosyl transferase (RefSeq) | 195, 276 |
| BSU34290 | epsI | putative polysaccharide pyruvyl transferase (RefSeq) | 195, 276 |
| BSU34300 | epsH | putative glycosyltransferase involved in biofilm formation (RefSeq) | 195, 276 |
| BSU34310 | epsG | biofilm extracellular matrix formation enzyme (RefSeq) | 195, 276 |
| BSU34320 | epsF | putative glycosyltransferase involved in extracellular matrix formation (RefSeq) | 195, 276 |
| BSU34330 | epsE | putative glycosyltransferase (RefSeq) | 195, 276 |
| BSU34340 | epsD | putative extracellular matrix biosynthesis enzyme (RefSeq) | 195, 276 |
| BSU34350 | epsC | putative UDP-sugar epimerase (RefSeq) | 195, 276 |
| BSU34360 | epsB | protein tyrosine kinase (RefSeq) | 276, 349 |
| BSU34370 | epsA | modulator of protein tyrosine kinase EpsB (RefSeq) | 276, 349 |
| BSU34380 | slrR | transcriptional regulator (RefSeq) | 276, 349 |
| BSU39450 | yxeR | putative ethanolamine transporter (RefSeq) | 80, 276 |
| BSU39460 | yxeQ | putative catabolic enzyme (RefSeq) | 80, 276 |
| BSU39470 | yxeP | putative amidohydrolase (RefSeq) | 80, 144 |
| BSU39480 | yxeO | putative ABC transporter (ATP-binding protein) (RefSeq) | 80, 144 |
| BSU39490 | yxeN | putative ABC transporter (permease) (RefSeq) | 80, 144 |
| BSU39500 | yxeM | putative ABC transporter (binding lipoprotein) (RefSeq) | 80, 144 |
| BSU39510 | yxeL | putative acetyltransferase (RefSeq) | 80, 276 |
| BSU39520 | yxeK | putative monooxygenase (RefSeq) | 80, 144 |
| BSU39940 | yxaL | membrane associated protein kinase with beta-propeller domain (RefSeq) | 189, 276 |
| BSU39950 | yxaJ | putative integral inner membrane protein (RefSeq) | 276, 302 |
| BSU40550 | ppaC | putative manganese-dependent inorganic pyrophosphatase (RefSeq) | 80, 247 |
Gene Page Help
Network Tab
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation Tab
Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.
Motifs Tab
Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Functions Tab
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
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Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVis
Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
- 4. Interactions between source and target genes for a particular module
- 5. Module(s) that source gene and target genes belong to
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