Organism : Clostridium acetobutylicum | Module List :
CAC2702

Possible signal transduction protein (containing EAL, CBS and GGDEF domains) (NCBI ptt file)

CircVis
Functional Annotations (5)
Function System
FOG: EAL domain cog/ cog
cyclic nucleotide biosynthetic process go/ biological_process
phosphorus-oxygen lyase activity go/ molecular_function
intracellular signal transduction go/ biological_process
GGDEF tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for CAC2702
(Mouseover regulator name to see its description)

CAC2702 is regulated by 18 influences and regulates 0 modules.
Regulators for CAC2702 (18)
Regulator Module Operator
CAC0807 123 tf
CAC1032 123 tf
CAC1843 123 tf
CAC1869 123 tf
CAC2768 123 tf
CAC3406 123 tf
CAC3418 123 tf
CAC3488 123 tf
CAC3502 123 tf
CAC0189 333 tf
CAC0402 333 tf
CAC0951 333 tf
CAC1668 333 tf
CAC1915 333 tf
CAC2471 333 tf
CAC2768 333 tf
CAC2939 333 tf
CAC3472 333 tf

Warning: CAC2702 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
6898 8.40e-04 aGGagg
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6899 6.20e+02 cctCttcATACTcCattgg
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7318 1.80e+02 ggAG.gG
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7319 9.60e+02 TtAaGGaGgAc
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for CAC2702

CAC2702 is enriched for 5 functions in 3 categories.
Enrichment Table (5)
Function System
FOG: EAL domain cog/ cog
cyclic nucleotide biosynthetic process go/ biological_process
phosphorus-oxygen lyase activity go/ molecular_function
intracellular signal transduction go/ biological_process
GGDEF tigr/ tigrfam
Module neighborhood information for CAC2702

CAC2702 has total of 44 gene neighbors in modules 123, 333
Gene neighbors (44)
Gene Common Name Description Module membership
CAC0039 CAC0039 DNA segregation ATPase FtsK/SpoIIIE family protein, contains FHA domain (NCBI ptt file) 258, 333
CAC0048 CAC0048 Hypothetical protein, CF-17 family (NCBI ptt file) 264, 333
CAC0101 CAC0101 Methyl-accepting chemotaxis protein (NCBI ptt file) 241, 333
CAC0172 CAC0172 Predicted membrane protein (NCBI ptt file) 123, 328
CAC0363 CAC0363 Deoxyinosine 3'endonuclease (NCBI ptt file) 333, 347
CAC0364 CAC0364 Metal-dependent hydrolases of the metallobeta-lactamase superfamily (NCBI ptt file) 141, 333
CAC0402 CAC0402 Possible transcriptional regulatory protein, AsnC family (NCBI ptt file) 125, 333
CAC0574 CAC0574 Pectate lyase H (FS) (NCBI ptt file) 123, 256
CAC0705 CAC0705 Sugar ABC transporter, permease protein (NCBI ptt file) 65, 123
CAC0813 CAC0813 Hypothetical protein (NCBI ptt file) 123, 150
CAC0926 CAC0926 TPR-repeat-containing protein (NCBI ptt file) 123, 270
CAC1199 CAC1199 Hypothetical protein (NCBI ptt file) 86, 123
CAC1446 CAC1446 Hypothetical protein (NCBI ptt file) 123, 270
CAC1580 CAC1580 Hypothetical protein (NCBI ptt file) 90, 123
CAC1650 CAC1650 Hypothetical protein, CF-38 family (NCBI ptt file) 123, 270
CAC1844 CAC1844 Hypothetical protein (NCBI ptt file) 26, 123
CAC1845 motB Flagellar motor protein MotB (NCBI ptt file) 123, 137
CAC1846 motA Flagellar motor component MotA (NCBI ptt file) 102, 123
CAC2029 CAC2029 Hypothetical protein (NCBI ptt file) 141, 333
CAC2044 CAC2044 Hypothetical protein (NCBI ptt file) 141, 333
CAC2101 CAC2101 Hypothetical protein (NCBI ptt file) 54, 333
CAC2251 CAC2251 Uncharacterized conserved membrane protein, affecting LPS biosynthesis (NCBI ptt file) 123, 312
CAC2267 CAC2267 Hypothetical protein (NCBI ptt file) 111, 123
CAC2339 CAC2339 Uncharacterized protein, YBBK B.subtilis ortholog (NCBI ptt file) 76, 123
CAC2586 CAC2586 Predicted membrane protein (NCBI ptt file) 123, 169
CAC2636 CAC2636 Predicted GTPase, YSXC B.subtilis ortholog (NCBI ptt file) 102, 123
CAC2702 CAC2702 Possible signal transduction protein (containing EAL, CBS and GGDEF domains) (NCBI ptt file) 123, 333
CAC2720 CAC2720 Sensory protein containing histidine kinase, PAS anf GAF domains (NCBI ptt file) 102, 123
CAC2748 deaD ATP dependent RNA helicase DeaD, superfamily II (NCBI ptt file) 59, 333
CAC2766 CAC2766 Thiamine biosynthesis lipoprotein ApbE (NCBI ptt file) 46, 333
CAC2768 CAC2768 Transcriptional regulators, AcrR family (NCBI ptt file) 241, 333
CAC2792 CAC2792 Uncharcterized conserved membrane protein, YXAI B.subtilis homolog (NCBI ptt file) 148, 333
CAC2811 CAC2811 Hypothetical protein, CF-17 family (NCBI ptt file) 123, 258
CAC2816 CAC2816 Hypothetical protein, CF-17 family (NCBI ptt file) 241, 333
CAC2981 CAC2981 Mannose-1-phosphate guanyltransferase (pyrophosphorylase domain and phosphomannomutase domain) (NCBI ptt file) 118, 123
CAC3045 CAC3045 CPSB/CAPC ortholog, PHP family hydrolase (NCBI ptt file) 272, 333
CAC3256 CAC3256 Predicted acetyltransferase (NCBI ptt file) 123, 341
CAC3257 CAC3257 Predicted membrane protein (NCBI ptt file) 137, 333
CAC3415 CAC3415 ABC-type multidrug/protein/lipid transport system, ATPase component (NCBI ptt file) 123, 208
CAC3431 CAC3431 Membrane export protein, related to SecD/SecF protein exporters (NCBI ptt file) 141, 333
CAC3432 CAC3432 Alpha/beta superfamily hydrolase (NCBI ptt file) 141, 333
CAC3532 CAC3532 Hypothetical protein (NCBI ptt file) 241, 333
CAC3689 CAC3689 Uncharacterized conserved protein, phnB family (NCBI ptt file) 125, 333
CAC3697 CAC3697 Uncharacterized, Zn-finger domain containing protein, YXKC B.subtilis homolog (NCBI ptt file) 123, 150
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for CAC2702
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend