Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 71 - 80 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_162	20 CD630_09430 - Type: Gene Product:Putative phage DNA-binding protein \| Pathway: \| COG: Function unknown CD630_36260 - Type: Gene Product:Putative 4-hydroxy-2-oxoglutarate aldolase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_36300 - Type: Gene Product:PTS system, fructose/mannitol-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_28970 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_36310 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_29020 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_36290 - Type: Gene Product:PTS system, fructose/mannitol-family IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_28960 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_36430 - Type: Gene Product:Dihydroorotase \| Pathway: \| COG: Function unknown CD630_36420 - Type: Gene Product:Putative selenocysteine synthase \| Pathway: \| COG: Amino acid transport and metabolism CD630_09440 - Type: Gene Product:Putative phage terminase, large subunit \| Pathway: \| COG: Replication, recombination and repair CD630_29070 - Type: Gene Product:Putative phage lipoprotein \| Pathway: \| COG: Function unknown CD630_28990 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_36280 - Type: Gene Product:Putative phosphosugar isomerase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_09450 - Type: Gene Product:Putative phage portal protein \| Pathway: \| COG: Function unknown CD630_36440 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36410 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36270 - dapA4 Type: Gene Product:Dihydrodipicolinate synthase 4 (DHDPS) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_29000 - Type: Gene Product:Putative phage tail protein \| Pathway: \| COG: Function unknown CD630_29060 - Type: Gene Product:Putative phage protein \| Pathway: \| COG:	0.02	`NA`	0.37	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_36390 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_163	25 CD630_18840 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_27540 - Type: Gene Product:Putative diguanylate kinase signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_21991 - Type: Gene Product:Putative 4Fe-4S ferredoxin iron-sulfur bindingdomain-containing protein \| Pathway: \| COG: Energy production and conversion CD630_21990 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,alpha subunit \| Pathway: \| COG: Energy production and conversion CD630_22000 - hisC Type: Gene Product:Histidinol-phosphate aminotransferase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_06190 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_21440 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_23740 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_22660 - Type: Gene Product:Putative oxidoreductase, FAD dependent \| Pathway: \| COG: Energy production and conversion CD630_35420 - spmA Type: Gene Product:Spore maturation protein A \| Pathway: \| COG: Function unknown CD630_21970 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,gamma subunit \| Pathway: \| COG: Energy production and conversion CD630_23130 - Type: Gene Product:ABC-type transport system, molybdenum-likeATP-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_32520 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27530 - Type: Gene Product:Putative signaling protein \| Pathway: \| COG: Signal transduction mechanisms CD630_21430 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_21980 - Type: Gene Product:Putative ferredoxin/flavodoxin oxidoreductase,beta subunit \| Pathway: \| COG: Energy production and conversion CD630_23110 - Type: Gene Product:ABC-type transport system, molybdenum-likeextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06200 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23750 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23120 - Type: Gene Product:ABC-type transport system, molybdenum-likepermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_23140 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_35410 - spmB Type: Gene Product:Spore maturation protein B \| Pathway: \| COG: Function unknown CD630_22650 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_21960 - Type: Gene Product:Putative succinyl-CoA synthetase-like ATP-bindingprotein \| Pathway: \| COG: Energy production and conversion CD630_32510 - Type: Gene Product:Putative dehydrogenase \| Pathway: \| COG: Function unknown	0.000000000047	0.03	0.48	Inferelator: 2 Hypergeometric: 2 TF Influences from Inferelator CD630_25990 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription
Module_164	4 CD630_19500 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_19300 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_28980 - Type: Gene Product:Putative phage tail fiber protein \| Pathway: \| COG: Function unknown CD630_15900 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown	0.12	`NA`	0.53	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_26400 - nrdR Type: Gene Product:Transcriptional regulator, repressor NrdR family \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_165	5 CD630_11140 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn4-Orf5 \| Pathway: \| COG: CD630_07660 - srlEb Type: Gene Product:PTS system, sorbitol-specific IIB C-terminalcomponent (Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03150 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_07650 - srlEa Type: Gene Product:PTS system, sorbitol-specific IIB N-terminalcomponent (Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_33410 - Type: Gene Product:Fragment of putative conjugative transposonprotein Tn916-like, CTn6-Orf18 (N-terminal region) \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.40	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_07630 - srlM Type: Gene Product:Sorbitol operon activator protein (Glucitol) \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_166	20 CD630_16830 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_25590 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Replication, recombination and repair CD630_16820 - iunH Type: Gene Product:Putative nucleoside hydrolase, IUNH family \| Pathway: \| COG: Nucleotide transport and metabolism CD630_11760 - Type: Gene Product:Conserved hypothetical protein, DUF177 family \| Pathway: \| COG: Function unknown CD630_25580 - coaD Type: Gene Product:Phosphopantetheine adenylyltransferase(Pantetheine-phosphate adenylyltransferase) \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_16840 - Type: Gene Product:Putative radical SAM superfamily protein \| Pathway: \| COG: Function unknown CD630_04520 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Nucleotide transport and metabolism CD630_25610 - Type: Gene Product:Putative phosphatase \| Pathway: \| COG: Function unknown CD630_25570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_11750 - ackA Type: Gene Product:Acetate kinase (Acetokinase) \| Pathway: Metabolic intermediate biosynthesis \| COG: Energy production and conversion CD630_04530 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_20580 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25620 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_04510 - Type: Gene Product:Putative dioxygenase \| Pathway: \| COG: Function unknown CD630_25600 - recG Type: Gene Product:ATP-dependent DNA helicase RecG \| Pathway: \| COG: Replication, recombination and repair CD630_20590 - glnS Type: Gene Product:Glutaminyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_11761 - rpmF Type: Gene Product:50S ribosomal protein L32 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_15220 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_21890 - pgmB Type: Gene Product:Beta-phosphoglucomutase (beta-D-Glucose1,6-phosphomutase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_21880 - mapA Type: Gene Product:Maltose phosphorylase/glycosyl hydrolase/vacuolaracid trehalase \| Pathway: \| COG: Carbohydrate transport and metabolism	`NA`	2.1	0.46	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_167	28 CD630_19260 - eutR Type: Gene Product:Fragment of transcription regulator, AraC family(C-terminal region) \| Pathway: \| COG: Transcription CD630_21210 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25980 - Type: Gene Product:Putative oligosaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_32570 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05560 - Type: Gene Product:Putative sugar isomerase / endonuclease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05520 - prsW Type: Gene Product:Site-1 protease \| Pathway: \| COG: Function unknown CD630_05540 - sip2 Type: Gene Product:Signal peptidase type I \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_05500 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_32580 - Type: Gene Product:Iron hydrogenase \| Pathway: \| COG: Energy production and conversion CD630_34880 - gtaB Type: Gene Product:UTP--glucose-1-phosphate uridylyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_23730 - Type: Gene Product:Putative CstA-like carbon starvation protein \| Pathway: \| COG: Signal transduction mechanisms CD630_07120 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33120 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15750 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_27190 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_24580 - Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05570 - Type: Gene Product:Putative uridine kinase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_25990 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_05550 - sip2 Type: Gene Product:Signal peptidase type I \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_14300 - pdaA Type: Gene Product:Exported N-acetylmuramic acid deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05510 - sleC Type: Gene Product:Spore exo-acting lytic transglycosylase \| Pathway: \| COG: Function unknown CD630_05530 - Type: Gene Product:Putative RNA methyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_14630 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_30070 - Type: Gene Product:Putative L,D-transpeptidases \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_23052 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15790 - Type: Gene Product:Two-component sensor histidine kinase,sporulation-associated spo0A \| Pathway: \| COG: Signal transduction mechanisms CD630_22520 - Type: Gene Product:Glutamate 2,3-aminomutase \| Pathway: \| COG: Amino acid transport and metabolism CD630_34890 - Type: Gene Product:Putative oligoendopeptidase F, peptidase M3Bfamily \| Pathway: \| COG: Amino acid transport and metabolism	0.00000029	`NA`	0.51	Inferelator: 5 Hypergeometric: 1 TF Influences from Inferelator CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_25990 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_26420 - sigG Type: Gene Product:RNA polymerase sigma-G factor \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms
Module_168	21 CD630_07300 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_07360 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_07310 - Type: Gene Product:Putative radical SAM superfamily protein \| Pathway: \| COG: Function unknown CD630_07330 - Type: Gene Product:Putative biotin/lipoate-protein ligase \| Pathway: Protein modification \| COG: Coenzyme transport and metabolism CD630_07180 - fhs Type: Gene Product:Formate--tetrahydrofolate ligase(Formyltetrahydrofolate synthetase) (FHS) (FTHFS) \| Pathway: One-carbon metabolism \| COG: Nucleotide transport and metabolism CD630_29270 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_07210 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_07240 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase,nickel-inserting subunit \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_07280 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase, subunit alpha/beta \| Pathway: \| COG: Energy production and conversion CD630_07190 - fchA Type: Gene Product:Methenyltetrahydrofolate cyclohydrolase(5,10-methenyltetrahydrofolate 5-hydrolase) \| Pathway: \| COG: Amino acid transport and metabolism CD630_07220 - metF Type: Gene Product:5,10-methylenetetrahydrofolate reductase \| Pathway: One-carbon metabolism \| COG: Amino acid transport and metabolism CD630_07290 - gcvH Type: Gene Product:Glycine cleavage system H protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_07200 - folD Type: Gene Product:Bifunctional protein folD [Includes:Methylenetetrahydrofolate dehydrogenase ;Methenyltetrahydrofolate cyclohydrolase] \| Pathway: One-carbon metabolism \| COG: Coenzyme transport and metabolism CD630_07270 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase, methyltransferasesubunit \| Pathway: \| COG: Amino acid transport and metabolism CD630_07230 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase, dihydrolipoyldehydrogenase subunit \| Pathway: \| COG: Energy production and conversion CD630_07320 - Type: Gene Product:Putative radical SAM superfamily protein \| Pathway: \| COG: Coenzyme transport and metabolism CD630_07260 - Type: Gene Product:Bifunctional carbon monoxidedehydrogenase/acetyl-CoA synthase, delta subunit \| Pathway: \| COG: Energy production and conversion CD630_07340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_29280 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_07350 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	6.1	`NA`	0.52	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06480 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_19310 - lexA Type: Gene Product:Transcriptional regulator, LexA repressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_169	25 CD630_30190 - Type: Gene Product:Putative transporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_00220 - fusA1 Type: Gene Product:Elongation factor G (EF-G) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_00260 - clpC Type: Gene Product:class III stress response-related ATPase, AAA+superfamily \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_26330 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Energy production and conversion CD630_00240 - mcsA Type: Gene Product:Activator of protein kinase McsB \| Pathway: \| COG: Function unknown CD630_17980 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_00470 - ispD Type: Gene Product:2-C-methyl-D-erythritol 4-phosphatecytidylyltransferase \| Pathway: Isoprenoid biosynthesis \| COG: Lipid transport and metabolism CD630_17960 - Type: Gene Product:Putative nitrite and sulfite reductase subunit \| Pathway: \| COG: Energy production and conversion CD630_36020 - Type: Gene Product:Putative ATPase \| Pathway: \| COG: Cell cycle control, cell division, chromosome partitioning CD630_26300 - gpsA Type: Gene Product:Glycerol-3-phosphate dehydrogenase (NAD(P)+)(NAD(P)H-dependent glycerol-3-phosphate dehydrogenase) \| Pathway: Membrane lipid metabolism \| COG: Energy production and conversion CD630_05600 - nfo Type: Gene Product:Endonuclease IV \| Pathway: \| COG: Replication, recombination and repair CD630_00290 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_30180 - Type: Gene Product:Putative redox-active protein \| Pathway: \| COG: Function unknown CD630_00230 - ctsR Type: Gene Product:Transcriptional regulator, CtsR family \| Pathway: \| COG: Transcription CD630_00480 - ispF Type: Gene Product:2-C-methyl-D-erythritol 2,4-cyclodiphosphatesynthase \| Pathway: Isoprenoid biosynthesis \| COG: Lipid transport and metabolism CD630_35990 - rolA Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_26310 - Type: Gene Product:Putative membrane protein, UPF0078 family \| Pathway: Lipid metabolism \| COG: Function unknown CD630_26320 - Type: Gene Product:Putative GTP-binding protein EngA \| Pathway: \| COG: Nucleotide transport and metabolism CD630_00250 - mcsB Type: Gene Product:Tyrosine kinase protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_00270 - radA Type: Gene Product:DNA repair protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_00460 - Type: Gene Product:Putative lipoate-protein ligase \| Pathway: Protein modification \| COG: Coenzyme transport and metabolism CD630_36010 - Type: Gene Product:D-alanyl-D-alanine carboxypeptidase, M15 family(DD-peptidase) (DD-carboxypeptidase) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_17970 - Type: Gene Product:Coenzyme A disulfide reductase (CoA-disulfidereductase) (CoADR) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_36000 - rolB Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_00280 - disA Type: Gene Product:DNA integrity scanning protein disA \| Pathway: \| COG: Replication, recombination and repair	0.00000018	0.0000076	0.47	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_19980 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_27220 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_17	15 CD630_13011 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_21910 - Type: Gene Product:Putative phosphoesterase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_24461 - rpsU Type: Gene Product:30S ribosomal protein S21 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_04400 - cwp27 Type: Gene Product:Putative cell wall binding protein \| Pathway: \| COG: Function unknown CD630_21920 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_11241 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06350 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Function unknown CD630_26920 - Type: Gene Product:Putative threonine-phosphate decarboxylase \| Pathway: \| COG: Amino acid transport and metabolism CD630_26691 - Type: Gene Product:Putative Na(+)/H(+) antiporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_05130 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04880 - Type: Gene Product:Putative small multidrug resistance SugE-likeprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06340 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_26120 - Type: Gene Product:Putative amino acid permease \| Pathway: \| COG: Amino acid transport and metabolism CD630_04390 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27990 - cwp8 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis	0.000002	`NA`	0.59	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06940 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_170	31 CD630_28500 - Type: Gene Product:Transcriptional regulator, DeoR family \| Pathway: \| COG: Transcription CD630_20270 - Type: Gene Product:N-carbamoyl-L-amino acid hydrolase \| Pathway: \| COG: Amino acid transport and metabolism CD630_12950 - scpA Type: Gene Product:Segregation and condensation protein A \| Pathway: \| COG: Function unknown CD630_15950 - cysE Type: Gene Product:Serine acetyltransferase (SAT) \| Pathway: \| COG: Amino acid transport and metabolism CD630_28660 - Type: Gene Product:Putative modulator of DNA gyrase, peptidase U62 \| Pathway: \| COG: Function unknown CD630_12930 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_26130 - Type: Gene Product:Putative peptidase, M24 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_24810 - ung Type: Gene Product:Uracil-DNA glycosylase (UDG) \| Pathway: \| COG: Replication, recombination and repair CD630_07910 - Type: Gene Product:Conserved hypothetical protein, UPF0029 family \| Pathway: \| COG: Function unknown CD630_19950 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_14720 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein/permease \| Pathway: \| COG: Defense mechanisms CD630_19930 - Type: Gene Product:Putative decarboxylase \| Pathway: \| COG: Function unknown CD630_11910 - fbp Type: Gene Product:Fructose-1,6-bisphosphatase \| Pathway: Carbohydrate biosynthesis \| COG: Carbohydrate transport and metabolism CD630_33550 - Type: Gene Product:Putative nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_01680 - Type: Gene Product:Putative cyclic nucleotide-binding protein \| Pathway: \| COG: Signal transduction mechanisms CD630_12960 - scpB Type: Gene Product:Segregation and condensation protein B \| Pathway: \| COG: Transcription CD630_12920 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12940 - Type: Gene Product:Putative membrane-associated peptidase, M50family \| Pathway: \| COG: Function unknown CD630_24820 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_02750 - splB Type: Gene Product:Spore photoproduct (thymine dimer) lyase, radicalS-adenosylmethionine superfamily \| Pathway: \| COG: Replication, recombination and repair CD630_28680 - Type: Gene Product:Putative oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_28670 - Type: Gene Product:Putative regulatory protease, U62 family \| Pathway: \| COG: Function unknown CD630_00310 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_15940 - cysK Type: Gene Product:O-acetyl-serine thiol-lyase A(O-acetyl-sulfhydrylase)(OAS-TL) \| Pathway: \| COG: Amino acid transport and metabolism CD630_14730 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding/permease \| Pathway: \| COG: Defense mechanisms CD630_19960 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Signal transduction mechanisms CD630_26960 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_11900 - Type: Gene Product:Putative acyl-CoA N-acyltransferase \| Pathway: \| COG: Transcription CD630_33560 - Type: Gene Product:Transcriptional regulator, hxlR family \| Pathway: \| COG: Transcription CD630_15310 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_24830 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Coenzyme transport and metabolism	9e-28	0.00000033	0.62	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`