Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 81 - 90 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_171	21 CD630_25740 - thiN Type: Gene Product:Thiamine pyrophosphokinase (TPK) (Thiaminediphospho kinase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_25830 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25850 - def2 Type: Gene Product:Peptide deformylase 2 (PDF 2) (Polypeptidedeformylase 2 ) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_25840 - fmt Type: Gene Product:Methionyl-tRNA formyltransferase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_25810 - rsmB Type: Gene Product:Ribosomal RNA small subunit methyltransferase B(rRNA (cytosine-C(5)-)-methyltransferase) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_16870 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: CD630_25760 - Type: Gene Product:Putative GTPase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_25800 - Type: Gene Product:Putative radical SAM-family protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_25820 - Type: Gene Product:Putative metal-dependent peptidase \| Pathway: \| COG: Function unknown CD630_16880 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_25890 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25750 - rpe Type: Gene Product:Ribulose-phosphate 3-epimerase(Pentose-5-phosphate 3-epimerase) (PPE) (R5P3E) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16890 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_25880 - gmk Type: Gene Product:Guanylate kinase (GMP kinase) \| Pathway: \| COG: Nucleotide transport and metabolism CD630_16850 - Type: Gene Product:Putative binding protein \| Pathway: \| COG: Replication, recombination and repair CD630_25860 - priA Type: Gene Product:Primosomal protein N' (ATP-dependent helicasepriA) (Replication factor Y) \| Pathway: \| COG: Replication, recombination and repair CD630_25871 - rpoZ Type: Gene Product:DNA-directed RNA polymerase subunit omega (RNAPomega subunit) (Transcriptase subunit omega) (RNApolymerase omega subunit) \| Pathway: \| COG: Transcription CD630_19970 - Type: Gene Product:Putative proline iminopeptidase (PIP), S33family \| Pathway: \| COG: Function unknown CD630_19980 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_25870 - coaBC Type: Gene Product:Coenzyme A biosynthesis bifunctional proteinCoaBC; phosphopantothenoylcysteinesynthetase/decarboxylase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_16860 - Type: Gene Product:Transcriptional regulator, repressor-like \| Pathway: \| COG: Transcription	3.2	`NA`	0.42	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_172	8 CD630_16020 - Type: Gene Product:PTS system, lactose/cellobiose-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_19901 - Type: Gene Product:Fragment of transcriptional regulator,beta-lactams repressor (Part 2) \| Pathway: \| COG: Transcription CD630_27120 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14750 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_11740 - Type: Gene Product:Conserved hypothetical protein, DUF795 family,UPF0348 family \| Pathway: \| COG: Function unknown CD630_15980 - Type: Gene Product:Putative excinuclease ABC-like \| Pathway: \| COG: Replication, recombination and repair CD630_21510 - Type: Gene Product:Putative membrane protein, DUF819 family \| Pathway: \| COG: Function unknown CD630_01780 - Type: Gene Product:Putative ATPase \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.51	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_04020 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_20230 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_21940 - Type: Gene Product:Putative ROK protein \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_173	6 CD630_18040 - scrR Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_20170 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_06480 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_09070 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_29660 - adhE Type: Gene Product:Aldehyde-alcohol dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_06641 - cdd1 Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.59	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_05590 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_06480 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_17980 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_31750 - cggR Type: Gene Product:Transcriptional regulator, SorC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_174	24 CD630_18490 - Type: Gene Product:Putative conjugative transfer proteinTn1549-like, CTn5-Orf5 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_32350 - ssb Type: Gene Product:Single-stranded DNA-binding protein \| Pathway: \| COG: Replication, recombination and repair CD630_24650 - Type: Gene Product:Putative amino acid/polyamine transporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_18470 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf3 \| Pathway: \| COG: Function unknown CD630_16570 - gcvTPA Type: Gene Product:Bi-functional glycine dehydrogenase/aminomethyltransferase protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_18450 - Type: Gene Product:Putative membrane protein Tn1549-like, CTn5-Orf1 \| Pathway: \| COG: Function unknown CD630_16040 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_24680 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13540 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_18480 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf4 \| Pathway: \| COG: Function unknown CD630_05970 - cotF Type: Gene Product:Spore coat protein \| Pathway: \| COG: Function unknown CD630_24700 - gpr Type: Gene Product:Spore endopeptidase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_18460 - Type: Gene Product:Putative conjugative transposon proteinTn1549-like, CTn5-Orf2 \| Pathway: \| COG: Function unknown CD630_06930 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_16580 - gcvPB Type: Gene Product:Glycine decarboxylase \| Pathway: \| COG: Amino acid transport and metabolism CD630_16050 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription CD630_24690 - spoIIP Type: Gene Product:Stage II sporulation protein P \| Pathway: \| COG: Function unknown CD630_13530 - Type: Gene Product:Putative phosphomethylpyrimidine kinase \| Pathway: Cofactor metabolism \| COG: Coenzyme transport and metabolism CD630_13550 - cspB Type: Gene Product:Cold shock protein CspB \| Pathway: \| COG: Transcription CD630_16030 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Defense mechanisms CD630_09100 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_05980 - cotCB Type: Gene Product:Spore-coat protein CotCB; manganese catalase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_05960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0.000000021	0.00045	0.47	Inferelator: 1 Hypergeometric: 2 TF Influences from Inferelator CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms CD630_12300 - Type: Gene Product:RNA polymerase sigma-K factor SigK (Part 2) \| Pathway: \| COG: Transcription, Transcription
Module_175	12 CD630_19904 - Type: Gene Product:Fragment of conserved hypothetical protein \| Pathway: \| COG: CD630_21710 - Type: Gene Product:Fragment of putative sodium:dicarboxylatesymporter (Part 2) \| Pathway: \| COG: Energy production and conversion, Energy production and conversion CD630_05102 - Type: Gene Product:Fragment of putative conjugative transposonprotein Tn5397, CTn3-Orf5 (C-terminal region) \| Pathway: \| COG: CD630_23011 - Type: Gene Product:Fragment of putative phage protein (C-terminalregion) \| Pathway: \| COG: CD630_09030 - Type: Gene Product:Fragment of putative oxydoreductase (Part 1) \| Pathway: \| COG: Energy production and conversion, Energy production and conversion CD630_33580 - Type: Gene Product:Fragment of C-terminal transcriptional regulator,AsnC/Lrp family \| Pathway: \| COG: Transcription CD630_14370 - Type: Gene Product:Fragment of transcriptional regulator,sigma-54-dependent (N-terminal region) \| Pathway: \| COG: Transcription CD630_33810 - Type: Gene Product:Fragment of putative membrane protein Tn916-like,CTn7-orf17 (Part 2) \| Pathway: \| COG: Function unknown, Function unknown CD630_08080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06780 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: CD630_22840 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17452 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	`NA`	`NA`	0.51	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_176	27 CD630_32450 - prdR Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_31890 - Type: Gene Product:Putative NADPH-dependent FMN reductase \| Pathway: \| COG: Function unknown CD630_07970 - Type: Gene Product:Putative pyruvate carboxyltransferase \| Pathway: \| COG: Lipid transport and metabolism CD630_07420 - Type: Gene Product:Putative ethanolamine transporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_23690 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33290 - Type: Gene Product:Putative RNA polymerase sigma factor Tn916-like,CTn6-Orf5 \| Pathway: \| COG: Function unknown CD630_16120 - Type: Gene Product:Putative amidohydrolase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_32850 - pgi Type: Gene Product:Glucose-6-phosphate isomerase (GPI)(Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase)(PHI) \| Pathway: Carbohydrate biosynthesis \| COG: Carbohydrate transport and metabolism CD630_34050 - Type: Gene Product:Putative iron-onlyhydrogenase,electron-transferring subunit HymA-like \| Pathway: \| COG: Energy production and conversion CD630_34030 - Type: Gene Product:Putative formate/nitrite transporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_34070 - Type: Gene Product:Putative iron-only hydrogenase, catalytic subunitHymC-like \| Pathway: \| COG: Energy production and conversion CD630_26830 - Type: Gene Product:Putative propanediol utilization protein \| Pathway: Polyol metabolism \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_31900 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_21810 - Type: Gene Product:Putative alpha/beta hydrolase \| Pathway: \| COG: Function unknown CD630_20460 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_13790 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_27550 - ptsI Type: Gene Product:PTS system, EI component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03560 - xis Type: Gene Product:Excisionase Tn916-like, CTn1-Orf2 \| Pathway: \| COG: Function unknown CD630_32460 - Type: Gene Product:Putative surface protein \| Pathway: \| COG: Function unknown CD630_33280 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn6-Orf4 \| Pathway: \| COG: Function unknown CD630_25960 - Type: Gene Product:Putative pseudouridylate synthase, RluC/RluDfamily \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_25970 - lspA Type: Gene Product:Lipoprotein signal peptidase (Prolipoproteinsignal peptidase) (Signal peptidase II) (SPase II) \| Pathway: Protein modification \| COG: Cell wall/membrane/envelope biogenesis, Intracellular trafficking, secretion, and vesicular transport CD630_15111 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_31910 - Type: Gene Product:Putative oxidoreductase \| Pathway: \| COG: Energy production and conversion CD630_34060 - Type: Gene Product:Putative iron-onlyhydrogenase,electron-transferring subunit HymB-like \| Pathway: \| COG: Energy production and conversion CD630_34040 - cls Type: Gene Product:Cardiolipin synthetase (Cardiolipin synthase) (CLsynthase) \| Pathway: \| COG: Lipid transport and metabolism CD630_21100 - Type: Gene Product:Putative transaldolaseC-like \| Pathway: Carbohydrate degradation \| COG: Carbohydrate transport and metabolism	4e-31	`NA`	0.47	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_17980 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_31900 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_35440 - Type: Gene Product:Transcriptional regulator, AsnC/Lrp family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_177	21 CD630_05690 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_24640 - hemN Type: Gene Product:Oxygen-independent coproporphyrinogen-III oxidase(Coproporphyrinogenase) (Coprogen oxidase) \| Pathway: \| COG: Coenzyme transport and metabolism CD630_24670 - lepA Type: Gene Product:GTP-binding protein LepA \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_24620 - grpE Type: Gene Product:Protein grpE (HSP-70 cofactor) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27440 - relA Type: Gene Product:GTP pyrophosphokinase (RelA/SpoT) \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_27400 - hisS Type: Gene Product:Histidyl-tRNA synthetase (Histidine--tRNA ligase)(HisRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_24660 - Type: Gene Product:Putative tRNA-nucleotidyltransferase/Poly(A)polymerase family member \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_27240 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_01450 - Type: Gene Product:Putative resolvase, S1 RNA-bindingdomain-containing protein \| Pathway: \| COG: Transcription CD630_27250 - Type: Gene Product:Putative monogalactosyldiacylglycerol synthase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_05700 - Type: Gene Product:Putative lipoprotein \| Pathway: \| COG: Function unknown CD630_24630 - hrcA Type: Gene Product:Transcriptional regulator, Heat-induciblerepressor HrcA \| Pathway: \| COG: Transcription CD630_24600 - dnaJ Type: Gene Product:Chaperone protein DnaJ \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27410 - hemZ Type: Gene Product:Coproporphyrinogen III oxidase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_01460 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_28400 - serS1 Type: Gene Product:Seryl-tRNA synthetase 1 (Seryl-tRNA(Ser/Sec)synthetase 1) (Serine--tRNA ligase 1) (SerRS 1) \| Pathway: Aminoacyl-tRNA biosynthesis \| COG: Translation, ribosomal structure and biogenesis CD630_24610 - dnaK Type: Gene Product:Chaperone protein dnaK (Heat shock protein 70)(Heat shock 70 kDa protein) (HSP70) \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27450 - apt Type: Gene Product:Adenine phosphoribosyltransferase (APRT) \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_27430 - dtd Type: Gene Product:D-tyrosyl-tRNA(Tyr) deacylase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_27230 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_27420 - Type: Gene Product:Putative hydrolase beta-lactamase-like \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism	0.0000000037	`NA`	0.44	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_23830 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_24630 - hrcA Type: Gene Product:Transcriptional regulator, Heat-induciblerepressor HrcA \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_178	20 CD630_31180 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_29350 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_29370 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_29270 - Type: Gene Product:Transcriptional regulator, Phage-type \| Pathway: \| COG: Transcription CD630_15920 - kdpB Type: Gene Product:Potassium-transporting ATPase B chain \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_17950 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17940 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_30941 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15831 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_29360 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	0.04	`NA`	0.54	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_32800 - Type: Gene Product:Sigma-54 dpendent regulator, PTS fructose family \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_179	26 CD630_01080 - nrdD Type: Gene Product:Anaerobic ribonucleoside triphosphate reductase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_11650 - Type: Gene Product:Putative ribosome-associated protein \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_r0050 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_r0280 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_11630 - rpmA Type: Gene Product:50S ribosomal protein L27 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_11610 - rplU Type: Gene Product:50S ribosomal protein L21 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_06770 - sigT Type: Gene Product:Extra-Cytoplasmic Function sigma factors, ECFfamily \| Pathway: \| COG: Transcription CD630_11590 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_11640 - obgE Type: Gene Product:Spo0B-associated GTP-binding protein \| Pathway: \| COG: Energy production and conversion CD630_24400 - Type: Gene Product:Putative metal-dependent hydrolase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_r0230 - 23s_rRNA Type: Gene Product: \| Pathway: \| COG: CD630_t0810 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_01090 - nrdG Type: Gene Product:Anaerobic ribonucleoside-triphosphatereductase-activating protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_31760 - glnF Type: Gene Product:RNA polymerase sigma-54 factor \| Pathway: \| COG: Transcription CD630_11600 - rng Type: Gene Product:Ribonuclease G (RNase G) (Cytoplasmic axialfilament protein) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_11620 - Type: Gene Product:Putative ribosome-associated protein \| Pathway: \| COG: Function unknown CD630_24390 - Type: Gene Product:Putative diacylglycerol kinase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_11580 - Type: Gene Product:Putative radical SAM-superfamily protein \| Pathway: \| COG: Energy production and conversion CD630_06760 - rsiT Type: Gene Product:Anti Sigma factors, ECF family \| Pathway: \| COG: Function unknown CD630_01070 - aspC Type: Gene Product:Aspartate aminotransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_24360 - Type: Gene Product:Putative divalent cation transporter, MgtEfamily \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_r0150 - 5s_rRNA Type: Gene Product: \| Pathway: \| COG:	0.000000026	0.00000027	0.42	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_06480 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_18	20 CD630_06890 - Type: Gene Product:Putative nucleotide phosphodiesterase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_19870 - cwp28 Type: Gene Product:Putative cell wall binding protein \| Pathway: \| COG: Function unknown CD630_03910 - asnB Type: Gene Product:Asparagine synthetase [glutamine-hydrolyzing] \| Pathway: \| COG: Amino acid transport and metabolism CD630_32300 - bclA2 Type: Gene Product:Exosporium glycoprotein \| Pathway: \| COG: Function unknown CD630_15951 - Type: Gene Product:Ferredoxin \| Pathway: \| COG: Energy production and conversion CD630_07960 - Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_19060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_24411 - Type: Gene Product:PhoH-like protein \| Pathway: \| COG: Signal transduction mechanisms CD630_32310 - hpt Type: Gene Product:Hypoxanthine phosphoribosyltransferase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_31590 - Type: Gene Product:Putative FemA-like peptidoglycan biosynthesisprotein \| Pathway: \| COG: Function unknown CD630_21520 - Type: Gene Product:Putative glutamyl-aminopeptidase, M42 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_25370 - Type: Gene Product:Putative membrane-associated5'-nucleotidase/phosphoesterase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_12590 - brnQ-1 Type: Gene Product:Branched chain amino acid transport systemcarrier protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_19040 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_27990 - cwp8 Type: Gene Product:Cell wall binding protein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis	0.00000000000017	`NA`	0.63	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_26400 - nrdR Type: Gene Product:Transcriptional regulator, repressor NrdR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`