Organism : Geobacter sulfurreducens | Module List :
GSU0369

FlhB domain protein, putative (NCBI)

CircVis
Functional Annotations (3)
Function System
Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB cog/ cog
protein secretion go/ biological_process
membrane go/ cellular_component
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for GSU0369
(Mouseover regulator name to see its description)

GSU0369 is regulated by 16 influences and regulates 0 modules.
Regulators for GSU0369 (16)
Regulator Module Operator
GSU0164 300 tf
GSU1270 300 tf
GSU2202 300 tf
GSU2716 300 tf
GSU2779 300 tf
GSU3217 300 tf
GSU0254 293 tf
GSU0266 293 tf
GSU0473 293 tf
GSU1115 293 tf
GSU1250 293 tf
GSU1495 293 tf
GSU1831 293 tf
GSU2915 293 tf
GSU3217 293 tf
GSU3387 293 tf

Warning: GSU0369 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
2744 7.60e+04 gAAAAcca.TccTtcCaGtG
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2745 1.20e+04 ggatCggCaTTAtgCtcgatT
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2758 1.40e-07 AaaTtgaCcc.tTCttccTCTaTC
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2759 1.00e-06 CCGacCCTcCAGGtCGgCtAg
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for GSU0369

GSU0369 is enriched for 3 functions in 3 categories.
Enrichment Table (3)
Function System
Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB cog/ cog
protein secretion go/ biological_process
membrane go/ cellular_component
Module neighborhood information for GSU0369

GSU0369 has total of 53 gene neighbors in modules 293, 300
Gene neighbors (53)
Gene Common Name Description Module membership
GSU0044 GSU0044 salmonella virulence plasmid 65kDa B protein /YD repeat protein (NCBI) 274, 300
GSU0045 GSU0045 hypothetical protein (VIMSS) 232, 300
GSU0048 GSU0048 integrase (NCBI) 287, 300
GSU0223 GSU0223 protoheme IX farnesyl transferase, putative (VIMSS) 257, 300
GSU0276 GSU0276 secretion protein, HlyD family (VIMSS) 217, 293
GSU0369 GSU0369 FlhB domain protein, putative (NCBI) 293, 300
GSU0595 GSU0595 hypothetical protein (NCBI) 300, 337
GSU0748 GSU0748 hypothetical protein (VIMSS) 217, 293
GSU0947 GSU0947 ABC transporter, ATP-binding protein (VIMSS) 272, 293
GSU0993 GSU0993 conserved hypothetical protein (VIMSS) 283, 293
GSU1034 GSU1034 None 287, 300
GSU1155 GSU1155 glutaredoxin family protein (VIMSS) 51, 293
GSU1172 mviN virulence factor mviN protein (NCBI) 295, 300
GSU1270 pyrR pyrimidine operon regulatory protein PyrR (NCBI) 281, 300
GSU1285 GSU1285 sensory box sensor histidine kinase/response regulator (VIMSS) 63, 293
GSU1295 GSU1295 conserved hypothetical protein (VIMSS) 266, 293
GSU1296 GSU1296 sensory box histidine kinase/response regulator (VIMSS) 293, 337
GSU1329 gltX tRNA synthetases class I (E and Q), catalytic domain protein (NCBI) 15, 300
GSU1359 GSU1359 helicase, putative (NCBI) 232, 293
GSU1383 dnaQ exonuclease (NCBI) 287, 300
GSU1406 GSU1406 conserved domain protein (VIMSS) 163, 293
GSU1539 xth exodeoxyribonuclease III (NCBI) 274, 300
GSU1565 GSU1565 hypothetical protein (VIMSS) 276, 300
GSU1643 pleD GGDEF/response regulator receiver domain protein (NCBI) 51, 293
GSU1678 GSU1678 cation-transport ATPase, E1-E2 family (VIMSS) 293, 318
GSU1680 GSU1680 conserved hypothetical protein (VIMSS) 59, 300
GSU1703 pfk 6-phosphofructokinase (NCBI) 204, 300
GSU1742 GSU1742 Na/Pi-cotransporter family protein (VIMSS) 287, 293
GSU1818 GSU1818 phosphoglycerate mutase family protein (NCBI) 163, 293
GSU1819 xerD integrase/recombinase XerD (NCBI) 163, 293
GSU2080 GSU2080 rod shape-determining protein MreD, putative (VIMSS) 137, 300
GSU2166 GSU2166 hypothetical protein (VIMSS) 1, 300
GSU2204 GSU2204 cytochrome c family protein, putative (NCBI) 300, 327
GSU2205 GSU2205 hypothetical protein (VIMSS) 300, 337
GSU2216 GSU2216 PBS lyase HEAT-like repeat protein (NCBI) 51, 293
GSU2336 otsB trehalose-phosphatase (NCBI) 296, 300
GSU2420 GSU2420 ferredoxin family protein (VIMSS) 57, 293
GSU2422 GSU2422 hydrogenase maturation protease (VIMSS) 283, 293
GSU2578 cheW-9 purine-binding chemotaxis protein CheW (NCBI) 79, 300
GSU2592 GSU2592 hypothetical protein (VIMSS) 68, 300
GSU2593 GSU2593 ISGsu6, transposase OrfA (VIMSS) 234, 300
GSU2594 GSU2594 ISGsu6, transposase OrfB (VIMSS) 287, 300
GSU2716 sfsA sugar fermentation stimulation protein (NCBI) 226, 300
GSU2890 GSU2890 cytochrome c biogenesis protein, CcmF/CcyK/CcsA family (VIMSS) 130, 300
GSU2957 GSU2957 thioredoxin family protein (VIMSS) 146, 300
GSU3159 GSU3159 MutT/nudix family protein (VIMSS) 293, 318
GSU3181 GSU3181 Beta-ketoacyl synthase domain protein (VIMSS) 163, 293
GSU3184 GSU3184 hypothetical protein (VIMSS) 181, 300
GSU3186 GSU3186 conserved hypothetical protein (VIMSS) 213, 300
GSU3264 GSU3264 membrane protein, putative (VIMSS) 295, 300
GSU3286 hemD uroporphyrinogen III synthase/methyltransferase (NCBI) 89, 300
GSU3354 GSU3354 MutT/nudix family protein (VIMSS) 226, 293
GSU3362 GSU3362 hypothetical protein (VIMSS) 232, 293
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for GSU0369
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend