Organism : Halobacterium salinarum NRC-1 | Module List :
VNG0061C

hypothetical protein VNG0061C

CircVis
Functional Annotations (3)
Function System
Arylsulfatase A and related enzymes cog/ cog
metabolic process go/ biological_process
sulfuric ester hydrolase activity go/ molecular_function
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for VNG0061C
(Mouseover regulator name to see its description)

VNG0061C is regulated by 7 influences and regulates 0 modules.
Regulators for VNG0061C (7)
Regulator Module Operator
VNG6143H 269 tf
VNG6389G 269 tf
VNG1510C 251 tf
VNG2112C 251 tf
VNG2579G 251 tf
VNG6389G 251 tf
VNG6438G 251 tf

Warning: VNG0061C Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
1435 1.40e+03 AAgAaTAc
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1436 7.60e+01 GagAtCGag.a.C.caggGAacgc
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1471 3.40e+03 tTtttATA.TACT.Aatt
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1472 1.90e+04 TaTtTaTTaATCTAT
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for VNG0061C

VNG0061C is enriched for 3 functions in 3 categories.
Enrichment Table (3)
Function System
Arylsulfatase A and related enzymes cog/ cog
metabolic process go/ biological_process
sulfuric ester hydrolase activity go/ molecular_function
Module neighborhood information for VNG0061C

VNG0061C has total of 59 gene neighbors in modules 251, 269
Gene neighbors (59)
Gene Common Name Description Module membership
VNG0021H hypothetical protein VNG0021H 251, 282
VNG0033H hypothetical protein VNG0033H 83, 269
VNG0061C hypothetical protein VNG0061C 251, 269
VNG0105H hypothetical protein VNG0105H 247, 269
VNG0112H hypothetical protein VNG0112H 251
VNG0159G mutL DNA mismatch repair protein 251, 268
VNG0160G boa1 bacterio-opsin activator-like protein 251, 267
VNG0200C hypothetical protein VNG0200C 251
VNG0214C hypothetical protein VNG0214C 190, 269
VNG0280H hypothetical protein VNG0280H 269
VNG0298H hypothetical protein VNG0298H 57, 269, 298
VNG0319H hypothetical protein VNG0319H 269
VNG0329G caaX zinc metalloproteinase-like protein 269
VNG0346H hypothetical protein VNG0346H 118, 269
VNG0367H hypothetical protein VNG0367H 118, 269
VNG0384G trpE2 anthranilate synthase subunit alpha 27, 269, 274
VNG0387G ilvE1 branched-chain amino acid aminotransferase 27, 269, 274
VNG0389C hypothetical protein VNG0389C 27, 269, 274
VNG0415G purB adenylosuccinate lyase 27, 269, 274
VNG0442G rspA hypothetical protein VNG0442G 27, 269, 274
VNG0446G gcd glucose dehydrogenase 27, 269, 274
VNG0507C hypothetical protein VNG0507C 251, 270
VNG0650C hypothetical protein VNG0650C 251
VNG0713C hypothetical protein VNG0713C 251
VNG0812G htr18 Htr18 269
VNG0822C hypothetical protein VNG0822C 269
VNG0846C hypothetical protein VNG0846C 251, 282
VNG0852C hypothetical protein VNG0852C 269
VNG0861H hypothetical protein VNG0861H 269
VNG0915G hakA atrazine chlorohydrolase 269, 284
VNG1005H hypothetical protein VNG1005H 251, 282
VNG1014G yqjH trans lesion repair 251
VNG1062G rfbQ rhamnosyl transferase 251, 282
VNG1151H hypothetical protein VNG1151H 251, 282
VNG1218C hypothetical protein VNG1218C 251, 285
VNG1256G ribG 5-amino-6-(5-phosphoribosylamino)uracil reductase 251, 285
VNG1285G trh2 transcription regulator 251
VNG1353C hypothetical protein VNG1353C 269
VNG1786H hypothetical protein VNG1786H 269
VNG1929G tmk thymidylate kinase 251
VNG2019C hypothetical protein VNG2019C 251
VNG2101H hypothetical protein VNG2101H 269
VNG2167G dbp DNA-binding protein -like 251
VNG2172C hypothetical protein VNG2172C 251
VNG2183H hypothetical protein VNG2183H 251
VNG2376H hypothetical protein VNG2376H 269
VNG2380H hypothetical protein VNG2380H 251
VNG2429G dld D-lactate dehydrogenase 251
VNG2446H hypothetical protein VNG2446H 251
VNG2498H hypothetical protein VNG2498H 269
VNG2634H hypothetical protein VNG2634H 251
VNG6254C hypothetical protein VNG6254C 269
VNG6305C hypothetical protein VNG6305C 251
VNG7062 hypothetical protein VNG7062 251
VNG7067 hypothetical protein VNG7067 251
VNG7078 hypothetical protein VNG7078 269
VNG7082 hypothetical protein VNG7082 269
VNG7089 hypothetical protein VNG7089 251
VNG7137 hypothetical protein VNG7137 269
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for VNG0061C
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend