Organism : Rhodobacter sphaeroides 2.4.1 | Module List :
Glutathione S-transferase (NCBI)
Functional Annotations (1)
|Glutathione S-transferase||cog/ cog|
Regulation information for RSP_0769(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for RSP_0769
|Glutathione S-transferase||cog/ cog|
Module neighborhood information for RSP_0769
|Gene||Common Name||Description||Module membership|
|RSP_0089||RSP_0089||hypothetical protein (NCBI)||23, 110|
|RSP_0180||RSP_0180||ABC nitrate/sulfonate/bicarbonate transporter, inner membrane subunit (NCBI)||23, 288|
|RSP_0549||RSP_0549||hypothetical protein (NCBI)||71, 171|
|RSP_0678||RSP_0678||hypothetical protein (NCBI)||23, 329|
|RSP_0769||RSP_0769||Glutathione S-transferase (NCBI)||23, 71|
|RSP_0823||SHMT||serine hydroxymethyltransferase protein (NCBI)||71, 85|
|RSP_0885||SseA||Thiosulfate sulfurtransferase, Rhodanese-like (NCBI)||71, 171|
|RSP_0924||cinA||Predicted nucleotide-utilizing enzyme/competence-damage associated protein (NCBI)||71, 286|
|RSP_0931||ialA||NUDIX hydrolase (NCBI)||23, 240|
|RSP_0950||RSP_0950||Arginine utilization protein RocB (NCBI)||23, 133|
|RSP_1004||RSP_1004||hypothetical protein (NCBI)||23, 326|
|RSP_1008||RSP_1008||4-hydroxybenzoate octaprenyltransferase (NCBI)||71, 164|
|RSP_1009||RSP_1009||possible outer membrane protein, OmpA family (NCBI)||71, 164|
|RSP_1033||RSP_1033||OmpA family protein (NCBI)||16, 71|
|RSP_1322||fhlB||flagellar biosynthesis pathway, component FlhB (NCBI)||23, 242|
|RSP_1415||RSP_1415||putative polysaccharide deacetylase (NCBI)||23, 329|
|RSP_1416||RSP_1416||hypothetical protein (NCBI)||23, 329|
|RSP_1417||RSP_1417||hypothetical protein (NCBI)||23, 133|
|RSP_1460||RSP_1460||hypothetical protein (NCBI)||71, 93|
|RSP_1463||RSP_1463||Putative acyl-CoA transferase/carnitine dehydratase (NCBI)||23, 306|
|RSP_1489||RSP_1489||Protein containing thioredoxin domain (NCBI)||30, 71|
|RSP_1523||RSP_1523||hypothetical protein (NCBI)||23, 174|
|RSP_1537||RSP_1537||hypothetical protein (NCBI)||23, 101|
|RSP_1760||RSP_1760||hypothetical protein (NCBI)||71, 377|
|RSP_1808||trpS||tryptophanyl-tRNA synthetase (NCBI)||71, 360|
|RSP_1843||ftsY||Signal recognition particle-docking protein FtsY (NCBI)||71, 309|
|RSP_1851||metZ||O-succinylhomoserine sulfhydrylase (NCBI)||71, 360|
|RSP_2007||RSP_2007||conservd hypothetical protein (NCBI)||64, 71|
|RSP_2017||RSP_2017||hypothetical protein (NCBI)||23, 126|
|RSP_2145||trgA||Tellurite resistance protein (NCBI)||23, 121|
|RSP_2147||cysK||O-acetylserine (Thiol)-lyase, cysteine synthase (NCBI)||71, 184|
|RSP_2193||gcvT||predicted aminomethyltransferase, tetrahydrofolate dependent (NCBI)||71, 309|
|RSP_2251||RSP_2251||putative beta-ketoadipate enol-lactone hydrolase (NCBI)||23, 220|
|RSP_2286||RSP_2286||hypothetical protein (NCBI)||23, 35|
|RSP_2295||RSP_2295||hypothetical protein (NCBI)||23, 154|
|RSP_2336||RSP_2336||hypothetical protein (NCBI)||71, 181|
|RSP_2354||RSP_2354||hypothetical protein (NCBI)||23, 83|
|RSP_2387||RSP_2387||hypothetical protein (NCBI)||71, 286|
|RSP_2408||RSP_2408||hypothetical protein (NCBI)||71, 322|
|RSP_2418||pldB||putative Esterase/lipase/thioesterase (NCBI)||23, 357|
|RSP_2453||RSP_2453||putative oxidoreductase (NAD/NADP dependent) (NCBI)||71, 166|
|RSP_2768||RSP_2768||5-methyltetrahydrofolate S-homocysteine methyltransferase (NCBI)||27, 71|
|RSP_2953||RSP_2953||glutaredoxin-related protein (NCBI)||23, 237|
|RSP_2975||RSP_2975||hypothetical protein (NCBI)||71, 309|
|RSP_2985||RSP_2985||hypothetical protein (NCBI)||71, 181|
|RSP_2986||RSP_2986||ArgE/DapE/Acy1 family protein (NCBI)||52, 71|
|RSP_2987||RSP_2987||probable acetyltransferase (NCBI)||71, 181|
|RSP_3072||sndh||putative L-sorbosone dehydrogenase (NCBI)||23, 72|
|RSP_3101||RSP_3101||periplasmic sensor diguanylate cyclase/phosphodiesterase (NCBI)||23, 174|
|RSP_3211||cbiO||ABC cobalt transporter, ATPase subunit, CbiO (NCBI)||23, 244|
|RSP_3511||RSP_3511||two component transcriptional regulator, winged helix family family (NCBI)||23, 239|
|RSP_3572||galM||putative aldose 1-epimerase protein (NCBI)||23, 30|
|RSP_3807||RSP_3807||hypothetical protein (NCBI)||23, 344|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
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Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
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