Organism : Clostridium acetobutylicum | Module List :
AP superfamily (NCBI ptt file)
Functional Annotations (5)
|Uncharacterized proteins of the AP superfamily||cog/ cog|
|phosphodiesterase I activity||go/ molecular_function|
|nucleotide diphosphatase activity||go/ molecular_function|
|nucleotide metabolic process||go/ biological_process|
|hydrolase activity||go/ molecular_function|
Regulation information for CAC0477(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for CAC0477
Module neighborhood information for CAC0477
|Gene||Common Name||Description||Module membership|
|CAC0038||CAC0038||Hypothetical protein (NCBI ptt file)||44, 258|
|CAC0039||CAC0039||DNA segregation ATPase FtsK/SpoIIIE family protein, contains FHA domain (NCBI ptt file)||258, 333|
|CAC0122||cheY||Chemotaxis respons regulator (cheY) (NCBI ptt file)||167, 247|
|CAC0132||CAC0132||Hypothetical protein (NCBI ptt file)||247, 270|
|CAC0134||CAC0134||Hypothetical protein, CF-19 family (NCBI ptt file)||62, 247|
|CAC0135||CAC0135||Hypothetical protein, CF-23 family (NCBI ptt file)||13, 247|
|CAC0223||CAC0223||Predicted N6-adenine-specific DNA methylase (NCBI ptt file)||65, 258|
|CAC0250||CAC0250||Methyl-accepting chemotaxis protein (NCBI ptt file)||207, 258|
|CAC0343||CAC0343||Hypothetical protein, CF-23 family (NCBI ptt file)||190, 258|
|CAC0355||CAC0355||Putative polygalacturonase (pectinase) (NCBI ptt file)||100, 258|
|CAC0399||CAC0399||Hypothetical protein, CF-24 family (NCBI ptt file)||258, 264|
|CAC0410||CAC0410||Uncharacterized small conserved protein, homolog of YUKE/YFJA (NCBI ptt file)||258, 264|
|CAC0419||CAC0419||Predicted membrane protein (NCBI ptt file)||247, 351|
|CAC0420||CAC0420||Conserved membrane protein, possible homolog of CAAX-like membrane endopeptidase (NCBI ptt file)||185, 247|
|CAC0477||CAC0477||AP superfamily (NCBI ptt file)||247, 258|
|CAC0485||CAC0485||TRNA-processing ribonuclease BN (NCBI ptt file)||137, 258|
|CAC0487||CAC0487||Uncharacterized protein, ortholog of Thermotoga maritima (4981823) (NCBI ptt file)||247, 259|
|CAC0509||CAC0509||PHP family protein (NCBI ptt file)||44, 258|
|CAC0568||asd||Aspartate semialdehyde dehydrogenase (gene asd) (NCBI ptt file)||26, 258|
|CAC0626||trpS||Tryptophan-tRNA synthetase, trpS (NCBI ptt file)||247, 296|
|CAC0864||CAC0864||Histidine kinase-like ATPase (NCBI ptt file)||65, 258|
|CAC0991||CAC0991||Putative intracellular protease (NCBI ptt file)||254, 258|
|CAC1256||CAC1256||Ribonucleases G/E family protein (NCBI ptt file)||84, 258|
|CAC1495||CAC1495||Enzyme of dihydrofolate reductase family, ortholog YWFD B.subtilis (NCBI ptt file)||5, 247|
|CAC1954||CAC1954||Hypothetical protein (NCBI ptt file)||22, 258|
|CAC2032||CAC2032||Hypothetical protein (NCBI ptt file)||3, 258|
|CAC2168||CAC2168||Uncharacterized conserved protein (NCBI ptt file)||258, 345|
|CAC2242||CAC2242||Predicted transcriptional regulator, arsE family (NCBI ptt file)||214, 247|
|CAC2495||CAC2495||Predicted transcriptional regulator (NCBI ptt file)||258, 326|
|CAC2547||CAC2547||Possible membrane-associated methyl-accepting chemotaxis protein fused to HAMP domain (NCBI ptt file)||145, 258|
|CAC2550||CAC2550||Hypothetical protein (NCBI ptt file)||3, 258|
|CAC2811||CAC2811||Hypothetical protein, CF-17 family (NCBI ptt file)||123, 258|
|CAC2823||CAC2823||Hypothetical protein (NCBI ptt file)||258, 341|
|CAC2824||CAC2824||N-terminal HKD family nuclease fused to DNA/RNA helicases of superfamily II,conserved in Streptomyces (NCBI ptt file)||154, 247|
|CAC2902||CAC2902||Isopentenyl monophosphate kinase, IPK (NCBI ptt file)||66, 247|
|CAC2939||CAC2939||Response regulator (CheY-like receiver domain and HTH-type DNA-binding domain) (NCBI ptt file)||258, 351|
|CAC2973||kdgA||2-keto-3-deoxy-6-phosphogluconate aldolase, eda/kdgA (NCBI ptt file)||108, 247|
|CAC3003||thyA||Thymidylate synthase (NCBI ptt file)||100, 258|
|CAC3004||folA||Dihydrofolate reductase (NCBI ptt file)||255, 258|
|CAC3232||CAC3232||Hypothetical protein (NCBI ptt file)||62, 247|
|CAC3236||CAC3236||Possible transcriptional regulator from YAEG/LRPR family (NCBI ptt file)||247, 312|
|CAC3277||nrdA||Ribonucleotide reductase alpha subunit (NCBI ptt file)||244, 258|
|CAC3380||CAC3380||Metallo-beta-lactamase superfamily hydrolase (NCBI ptt file)||108, 247|
|CAC3481||CAC3481||Transcriptional regulator, AcrR family (NCBI ptt file)||167, 247|
|CAC3524||CAC3524||Hypothetical protein, CF-7 family (NCBI ptt file)||226, 247|
|CAC3531||CAC3531||IS605/IS200-like transposase (NCBI ptt file)||190, 247|
|CAC3562||CAC3562||HD superfamily hydrolase (NCBI ptt file)||127, 247|
|CAC3563||CAC3563||Mismatch repair protein MutS-like ATPase (NCBI ptt file)||247, 335|
|CAC3649||spoVT||Possible stage V sporulation protein T, transcriptional regulator AbrB homolog (NCBI ptt file)||108, 247|
|CAC3677||kdpE||KDP operon transcriptional regulatory protein KdpE (CheY-like receiver domain and HTH-type DNA-binding domain) (NCBI ptt file)||108, 247|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
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Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
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