Organism : Methanococcus maripaludis S2 | Module List :
MMP0524

hypothetical protein MMP0524

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for MMP0524
(Mouseover regulator name to see its description)

MMP0524 is regulated by 4 influences and regulates 0 modules.
Regulators for MMP0524 (4)
Regulator Module Operator
MMP0168 58 tf
MMP0629
MMP1015
58 combiner
MMP0907 58 tf
MMP1015 58 tf

Warning: MMP0524 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 10 motifs predicted.

Motif Table (10)
Motif Id e-value Consensus Motif Logo
669 2.30e-02 GtGtgCtcccaac
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670 1.10e+04 GGGggAACc
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777 3.90e-01 accTaCAaaaatAca.tatAt
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778 1.20e+03 CGTTTCCTCGTGCAC
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943 1.30e+00 CtCCCCct
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944 1.90e+04 GGtAcgagCTTT.Ac.aG
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955 4.80e-01 CacCTGtcct.cA
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956 1.90e+02 G.cGCccAag
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973 1.90e+01 GaAaaTccGataTTttCACCc
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974 3.80e+02 gc.CGATtccaaAAC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for MMP0524

Warning: No Functional annotations were found!

Module neighborhood information for MMP0524

MMP0524 has total of 129 gene neighbors in modules 4, 58, 146, 153, 163
Gene neighbors (129)
Gene Common Name Description Module membership
Antisense_18 None 155, 163
Antisense_3 None 58, 70
Antisense_8 None 28, 153
MMP0011 DNA-cytosine methyltransferase 4, 104
MMP0050 ribH 6,7-dimethyl-8-ribityllumazine synthase 58, 98
MMP0051 hisE phosphoribosyl-ATP pyrophosphatase 58, 98
MMP0059 hypothetical protein MMP0059 8, 58, 64
MMP0096 putative GntR family transcriptional regulator 39, 58
MMP0097 transcriptional regulator 58, 166
MMP0105 hypothetical protein MMP0105 4, 107
MMP0122 hypothetical protein MMP0122 57, 102, 146
MMP0128 cyclase family protein 73, 146, 153
MMP0140 (NiFe) hydrogenase maturation protein HypF 4, 85
MMP0180 ribC riboflavin synthase 1, 58
MMP0181 hypothetical protein MMP0181 4, 58
MMP0188 diphthamide biosynthesis protein 42, 163
MMP0193 hypothetical protein MMP0193 144, 153
MMP0207 modC molybdenum ABC transporter ATP-binding protein 57, 153
MMP0209 hypothetical protein MMP0209 30, 58
MMP0210 hypothetical protein MMP0210 58, 140
MMP0216 cation transport ATPase 4, 41, 95
MMP0243 hypothetical protein MMP0243 4, 25, 38
MMP0256 hisH imidazole glycerol phosphate synthase subunit HisH 28, 58
MMP0257 tbp transcription factor 28, 58
MMP0296 hypothetical protein MMP0296 4, 129
MMP0307 hypothetical protein MMP0307 33, 49, 153
MMP0333 hypothetical protein MMP0333 4, 126
MMP0361 hypothetical protein MMP0361 42, 45, 163
MMP0362 hypothetical protein MMP0362 15, 163
MMP0365 hypothetical protein MMP0365 45, 163
MMP0366 hypothetical protein MMP0366 15, 163
MMP0367 hypothetical protein MMP0367 15, 163
MMP0368 hypothetical protein MMP0368 64, 163
MMP0369 hypothetical protein MMP0369 58, 151
MMP0379 hypothetical protein MMP0379 104, 163
MMP0392 purD phosphoribosylamine--glycine ligase 4, 75, 104
MMP0401 metE methionine synthase 4, 15, 80
MMP0412 MiaB-like tRNA modifying protein 4, 25, 87
MMP0424 hypothetical protein MMP0424 85, 163
MMP0426 nitroreductase family protein 57, 102, 106, 153
MMP0447 nitrogenase-like protein 4, 146
MMP0448 hypothetical protein MMP0448 4, 70
MMP0454 hypothetical protein MMP0454 85, 163
MMP0455 amino-acid ABC transporter 54, 146
MMP0479 hypothetical protein MMP0479 4, 95
MMP0480 hypothetical protein MMP0480 58, 99
MMP0487 hypothetical protein MMP0487 58, 98
MMP0499 hypothetical protein MMP0499 22, 28, 144, 146, 153
MMP0503 hypothetical protein MMP0503 4, 126
MMP0514 modA molybdenum ABC transporter periplasmic molybdate-binding protein 99, 146
MMP0520 HAD superfamily ATPase 73, 146
MMP0522 hypothetical protein MMP0522 42, 85, 146, 153
MMP0523 ABC transporter ATP-binding protein 42, 85, 146, 153
MMP0524 hypothetical protein MMP0524 4, 58, 146, 153, 163
MMP0525 hypothetical protein MMP0525 4, 146, 163
MMP0527 hypothetical protein MMP0527 76, 153
MMP0571 moaA molybdenum cofactor biosynthesis protein A 4, 89
MMP0594 hypothetical protein MMP0594 45, 163
MMP0613 acetolactate decarboxylase 58, 124
MMP0648 rtcA RNA 3'-terminal-phosphate cyclase 67, 146
MMP0665 hypothetical protein MMP0665 62, 163
MMP0690 polyferredoxin 72, 163
MMP0712 amino acid ABC transporter substrate-binding protein 58, 154
MMP0722 hypothetical protein MMP0722 58, 160
MMP0734 hypothetical protein MMP0734 30, 58, 154
MMP0757 hypothetical protein MMP0757 58, 146
MMP0775 hypothetical protein MMP0775 42, 146, 153, 163
MMP0784 hypothetical protein MMP0784 43, 163
MMP0785 dop chymotrypsin serine protease 2, 146, 159
MMP0788 hypothetical protein MMP0788 58, 117
MMP0794 hypothetical protein MMP0794 85, 163
MMP0813 hypothetical protein MMP0813 146, 166
MMP0828 hypothetical protein MMP0828 45, 85, 163
MMP0835 hypothetical protein MMP0835 85, 146
MMP0845 hypothetical protein MMP0845 45, 163
MMP0863 CBS domain-containing protein 2, 54, 146
MMP0864 napA-2 Na+/H+ exchanger 50, 146, 166
MMP0871 hypothetical protein MMP0871 22, 153, 166
MMP0886 cobalt ABC transporter inner membrane protein 4, 151
MMP0922 putative phage infection protein 58, 98
MMP0923 dapB dihydrodipicolinate reductase 58, 98
MMP0932 MCP methylation inhibitor CheC 58, 59, 98
MMP0948 hypothetical protein MMP0948 4, 115
MMP0949 tRNA CCA-pyrophosphorylase 4, 70
MMP0994 hypothetical protein MMP0994 67, 144, 153
MMP1000 hypothetical protein MMP1000 4, 95
MMP1027 hypothetical protein MMP1027 104, 163
MMP1064 adenylate cyclase 4, 51
MMP1110 hypothetical protein MMP1110 31, 146
MMP1119 yjlA hypothetical protein MMP1119 64, 163
MMP1124 thiamine-monophosphate kinase 102, 146
MMP1125 hypothetical protein MMP1125 69, 85, 163
MMP1130 hypothetical protein MMP1130 4, 38
MMP1134 type A flavoprotein 58, 123
MMP1135 flavodoxin:beta-lactamase-like 58, 123
MMP1136 rubrerythrin 58, 123
MMP1150 mtaA uroporphyrinogen decarboxylase 4, 41, 95
MMP1202 hypothetical protein MMP1202 104, 153
MMP1203 cbiD cobalt-precorrin-6A synthase 104, 153
MMP1228 hypothetical protein MMP1228 4, 22, 142
MMP1229 FUN14 family protein 58, 123
MMP1238 bioB biotin synthase 1, 153
MMP1243 UBA/THIF-type NAD/FAD binding protein 89, 146
MMP1303 sensory transduction histidine kinase 4, 28, 66
MMP1304 response regulator receiver protein 4, 126
MMP1305 hypothetical protein MMP1305 4, 126
MMP1307 methyltransferase-like protein 4, 149
MMP1309 hypothetical protein MMP1309 110, 163
MMP1389 hypothetical protein MMP1389 42, 163
MMP1423 aldehyde dehydrogenase 85, 163
MMP1439 cofactor-independent phosphoglycerate mutase 58, 123
MMP1493 hypothetical protein MMP1493 35, 58
MMP1494 hypothetical protein MMP1494 104, 153
MMP1501 phosphodiesterase 85, 163
MMP1550 NADP oxidoreductase, coenzyme F420-dependent 1, 58
MMP1578 nicotinamide-nucleotide adenylyltransferase 144, 153
MMP1605 pyruvate kinase 1, 54, 146, 166
MMP1636 major facilitator transporter 22, 65, 153
MMP1645 aspartate/glutamate/uridylate kinase 4, 126
MMP1655 hypothetical protein MMP1655 36, 42, 163
MMP1664 hypothetical protein MMP1664 42, 146
MMP1698 hypothetical protein MMP1698 4, 8
Mma-sR04 None 100, 146
RNA_17 tRNA-Pro2 Pro tRNA 4, 100
Unanno_10 None 64, 146
Unanno_23 None 4, 101
Unanno_27 None 4, 101
Unanno_47 None 58, 99
Unanno_51 None 4, 126
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for MMP0524
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend