two-component sensor activity

Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.
GO Category: 
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Signal transduction histidine kinase, subgroup 2
Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)