Module 6 Residual: 0.61

Title Bicluster Model Residual Score
bicluster_0006 v02 0.61 -5.60
Displaying 1 - 18 of 18
Rv0345 CTP:molybdopterin cytidylyltransferase

Details for Rv0345 - CTP:molybdopterin cytidylyltransferase

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.83 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0345

Tuberculist Genomic Region

Rv0509 Glutamyl-tRNA reductase (EC 1.2.1.70)

Details for Rv0509 - Glutamyl-tRNA reductase (EC 1.2.1.70)

GO Terms: GO:0008883, GO:0040007

PATRIC Pathways: Porphyrin and chlorophyll metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.03 | In vivo Essential: NA

Go to Gene Page: Rv0509

Tuberculist Genomic Region

Rv0510 Porphobilinogen deaminase (EC 2.5.1.61)

Details for Rv0510 - Porphobilinogen deaminase (EC 2.5.1.61)

GO Terms: GO:0004418, GO:0005886, GO:0040007

PATRIC Pathways: Porphyrin and chlorophyll metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.03 | In vivo Essential: NA

Go to Gene Page: Rv0510

Tuberculist Genomic Region

Rv0513 Transmembrane transport protein MmpL2

Details for Rv0513 - Transmembrane transport protein MmpL2

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.59 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv0513

Tuberculist Genomic Region

Rv1089 PE family protein

Details for Rv1089 - PE family protein

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.63 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1089

Tuberculist Genomic Region

Rv1173 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1 / 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2

Details for Rv1173 - 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1 / 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2

GO Terms: GO:0005886, GO:0009108, GO:0051409

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.01 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1173

Tuberculist Genomic Region

Rv1207 Non functional Dihydropteroate synthase 2

Details for Rv1207 - Non functional Dihydropteroate synthase 2

GO Terms: GO:0042803, GO:0004156

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.72 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1207

Tuberculist Genomic Region

Rv1208 Glycosyltransferases involved in cell wall biogenesis

Details for Rv1208 - Glycosyltransferases involved in cell wall biogenesis

GO Terms: GO:0000287, GO:0006011, GO:0016758, GO:0040007, GO:0042803, GO:0051260, GO:0070207

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.09 | In vivo Essential: NA

Go to Gene Page: Rv1208

Tuberculist Genomic Region

Rv2425c VWA containing CoxE family protein

Details for Rv2425c - VWA containing CoxE family protein

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.70 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2425c

Tuberculist Genomic Region

Rv2477c ABC transporter ATP-binding protein

Details for Rv2477c - ABC transporter ATP-binding protein

GO Terms: GO:0005829, GO:0005886, GO:0040007

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv2477c

Tuberculist Genomic Region

Rv2726c Diaminopimelate epimerase (EC 5.1.1.7)

Details for Rv2726c - Diaminopimelate epimerase (EC 5.1.1.7)

GO Terms: GO:0008837, GO:0005886, GO:0008837, GO:0040007

PATRIC Pathways: Lysine biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.11 | In vivo Essential: NA

Go to Gene Page: Rv2726c

Tuberculist Genomic Region

Rv2995c 3-isopropylmalate dehydrogenase (EC 1.1.1.85)

Details for Rv2995c - 3-isopropylmalate dehydrogenase (EC 1.1.1.85)

GO Terms: GO:0003862, GO:0003862, GO:0040007, GO:0042803

PATRIC Pathways: Valine, leucine and isoleucine biosynthesis

Essentiality: Griffin Essential: 0.01 | In vitro Essential: 0.14 | In vivo Essential: NA

Go to Gene Page: Rv2995c

Tuberculist Genomic Region

Rv3025c Cysteine desulfurase (EC 2.8.1.7)

Details for Rv3025c - Cysteine desulfurase (EC 2.8.1.7)

GO Terms: GO:0031071, GO:0016226, GO:0031071, GO:0040007

PATRIC Pathways: Thiamine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv3025c

Tuberculist Genomic Region

Rv3103c

Details for Rv3103c -

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.83 | In vitro Essential: NA | In vivo Essential: 0.29

Go to Gene Page: Rv3103c

Tuberculist Genomic Region

Rv3104c Potassium efflux system KefA protein / Small-conductance mechanosensitive channel

Details for Rv3104c - Potassium efflux system KefA protein / Small-conductance mechanosensitive channel

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.78 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3104c

Tuberculist Genomic Region

Rv3480c Wax ester synthase/acyl-CoA:diacylglycerol acyltransferase

Details for Rv3480c - Wax ester synthase/acyl-CoA:diacylglycerol acyltransferase

GO Terms: GO:0045017, GO:0047196

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.98 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3480c

Tuberculist Genomic Region

Rv3803c Antigen 85-C precursor (85C) (Antigen 85 complex C) (Ag85C) (Mycolyl transferase 85C) (EC 2.3.1.-)
Rv3843c PROBABLE CONSERVED TRANSMEMBRANE PROTEIN

Details for Rv3843c - PROBABLE CONSERVED TRANSMEMBRANE PROTEIN

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.13 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3843c

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 8.5 e-value: 1100
Displaying 1 - 1 of 1
regulates 26 modules
Weight: 
0.21
up-regulates
RNA polymerase sigma factor SigB
regulates 61 modules
Weight: 
0.18
up-regulates
Arsenical resistance operon repressor
regulates 5 modules
Weight: 
-0.16
down-regulates
Uracil phosphoribosyltransferase (EC 2.4.2.9) / Pyrimidine operon regulatory protein PyrR
regulates 90 modules
Weight: 
0.12
up-regulates
Transcriptional regulator, TetR family
regulates 54 modules
Weight: 
0.11
up-regulates
DNA-binding response regulator, LuxR family
regulates 29 modules
Weight: 
0.11
up-regulates
Arginine pathway regulatory protein ArgR, repressor of arg regulon
regulates 31 modules
Weight: 
0.10
up-regulates
regulates 43 modules
Weight: 
0.05
up-regulates
response regulator
regulates 69 modules
Weight: 
0.04
up-regulates
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
No enrichment
Displaying 1 - 22 of 22
GO:0008883 |

glutamyl-tRNA reductase activity

GO:0040007 |

growth

GO:0004418 |

hydroxymethylbilane synthase activity

GO:0005886 |

plasma membrane

GO:0009108 |

coenzyme biosynthetic process

GO:0051409 |

response to nitrosative stress

GO:0042803 |

protein homodimerization activity

GO:0004156 |

dihydropteroate synthase activity

GO:0000287 |

magnesium ion binding

GO:0006011 |

UDP-glucose metabolic process

GO:0016758 |

transferase activity, transferring hexosyl groups

GO:0051260 |

protein homooligomerization

GO:0070207 |

protein homotrimerization

GO:0005829 |

cytosol

GO:0008837 |

diaminopimelate epimerase activity

GO:0003862 |

3-isopropylmalate dehydrogenase activity

GO:0031071 |

cysteine desulfurase activity

GO:0016226 |

iron-sulfur cluster assembly

GO:0045017 |

glycerolipid biosynthetic process

GO:0047196 |

long-chain-alcohol O-fatty-acyltransferase activity

GO:0005576 |

extracellular region