Rv0033 Acyl carrier protein

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv0033 acpA Acyl carrier protein CDS 36607 36870 + 264 87 FALSE

Rv0033 (Acyl carrier protein) is predicted to be co-regulated in modules bicluster_0410 with residual 0.47 and bicluster_0548 with residual 0.54.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 1.20 and 4.10 for bicluster_0410 and 0.00 and 0.26 for bicluster_0548 respectively.

These modules are enriched for following go terms: .

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
ESX-1 secreted protein regulator EspR
Repressed -37 -1.95 0.0000509 CDS
Motif 1 Motif 2 Residual
bicluster_0410
e.value: 
1.2
Motif Bicluster: 
e.value: 
4.1
Motif Bicluster: 
0.47
bicluster_0548
e.value: 
0.000078
Motif Bicluster: 
e.value: 
0.26
Motif Bicluster: 
0.54
Product (LegacyBRC) Product (RefSeq)
PROBABLE ACYL CARRIER PROTEIN ACPA [ACP] acyl carrier protein AcpA
Operon # Operon
20 Rv0032 - Rv0033 - Rv0034 - Rv0035
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15607175 NP_214547.1 Run
GO:0000036

ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process

ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process

Details: 
Interacting selectively with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis.
GO Category: 
molecular_function
5
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.770000 1.59

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.