Rv0115 D,D-heptose 7-phosphate kinase

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv0115 hddA D,D-heptose 7-phosphate kinase CDS 138513 139673 + 1 161 386 FALSE

Rv0115 (D,D-heptose 7-phosphate kinase) is predicted to be co-regulated in modules bicluster_0380 with residual 0.52 and bicluster_0507 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.07 and 0.10 for bicluster_0380 and 0.00 and 0.00 for bicluster_0507 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 2 of 2
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulatory protein
Repressed 32 -1.26 0.000000941 Antisense.TSS
Repressed -124 -0.72 0.0478728 Antisense.TSS
Motif 1 Motif 2 Residual
bicluster_0380
e.value: 
0.066
Motif Bicluster: 
e.value: 
0.096
Motif Bicluster: 
0.52
bicluster_0507
e.value: 
0.00000000048
Motif Bicluster: 
e.value: 
0.0012
Motif Bicluster: 
0.50
Product (LegacyBRC) Product (RefSeq)
POSSIBLE D-ALPHA-D-HEPTOSE-7-PHOSPHATE KINASE HDDA D-alpha-D-heptose-7-phosphate kinase
Operon # Operon
76 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15607257 NP_214629.1 Run
GO:0005524

ATP binding

ATP binding

Details: 
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GO Category: 
molecular_function
58
Total items in this category:  
GO:0016310

phosphorylation

phosphorylation

Details: 
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
GO Category: 
biological_process
4
Total items in this category:  
GO:0016301

kinase activity

kinase activity

Details: 
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
GO Category: 
molecular_function
3
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.560000 1.06

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: