Rv0118c Oxalyl-CoA decarboxylase (EC 4.1.1.8)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv0118c oxcA Oxalyl-CoA decarboxylase (EC 4.1.1.8) CDS 142128 143876 - 1 749 582 FALSE

Rv0118c (Oxalyl-CoA decarboxylase (EC 4.1.1.8)) is predicted to be co-regulated in modules bicluster_0028 with residual 0.52 and bicluster_0438 with residual 0.51.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 1.50 for bicluster_0028 and 2.50 and 3,200.00 for bicluster_0438 respectively.

These modules are enriched for following go terms: signal transduction, signaling, single organism signaling, cell communication, response to stimulus, signal transducer activity, molecular transducer activity, phosphorelay sensor kinase activity, receptor activity, signaling receptor activity porphyrin-containing compound metabolic ..., porphyrin-containing compound biosynthet..., cofactor biosynthetic process, sulfur amino acid biosynthetic process, sulfur amino acid metabolic process, cofactor metabolic process.

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

BASS Score New Primary UTR Primary TSS Re-Annotated Start Tuberculist Annotated Start
-0.371 30 143876 143846 143876
Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulator, TetR family
No -62 -0.11 0.839933 Primary.TSS
Motif 1 Motif 2 Residual
bicluster_0028
e.value: 
0.00029
Motif Bicluster: 
e.value: 
1.5
Motif Bicluster: 
0.52
bicluster_0438
e.value: 
2.5
Motif Bicluster: 
e.value: 
3200
Motif Bicluster: 
0.51
Product (LegacyBRC) Product (RefSeq)
PROBABLE OXALYL-CoA DECARBOXYLASE OXCA putative oxalyl-CoA decarboxylase
Operon # Operon
79 Rv0118c
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Oxalyl-CoA decarboxylase Glyoxylate and dicarboxylate metabolism
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Glyoxylate and dicarboxylate metabolism

31
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15607260 NP_214632.1 Run
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0040007

growth

growth

Details: 
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
biological_process
621
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.390000 1.12

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.