Rv0194 ATP binding cassette (ABC) transporter homolog

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv0194 ATP binding cassette (ABC) transporter homolog CDS 226878 230462 + 3 585 1 194 FALSE

Rv0194 (ATP binding cassette (ABC) transporter homolog) is predicted to be co-regulated in modules bicluster_0226 with residual 0.52 and bicluster_0419 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 2,000.00 for bicluster_0226 and 0.02 and 10.00 for bicluster_0419 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 17:54
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-14744 MT0204 1280
Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 3 of 3
ChipSeq TF Differential Expression Distance Expression pvalue Type
Histone protein Lsr2
No -129 0.33 0.209234 CDS
Transcriptional regulator, LuxR family
Induced -140 4.99 0 CDS
Transcriptional regulator, TetR family
No -38 0.08 0.920771 CDS
Motif 1 Motif 2 Residual
bicluster_0226
e.value: 
0.000081
Motif Bicluster: 
e.value: 
2000
Motif Bicluster: 
0.52
bicluster_0419
e.value: 
0.024
Motif Bicluster: 
e.value: 
10
Motif Bicluster: 
0.50
Product (LegacyBRC) Product (RefSeq)
PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER drugs-transport transmembrane ATP-binding protein ABC transporter
Operon # Operon
134
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

ABC transporters

57
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15607335 NP_214708.1 Run
GO:0005618

cell wall

cell wall

Details: 
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan.
GO Category: 
cellular_component
320
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0015562

efflux transmembrane transporter activity

efflux transmembrane transporter activity

Details: 
Catalysis of the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.
GO Category: 
molecular_function
9
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.140000 1.10

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: