Rv0373c Carbon monoxide dehydrogenase form I, large chain( EC: )

Product Feature Type Start End Strand Length AA Length is TF
Rv0373c Carbon monoxide dehydrogenase form I, large chain( EC: ) CDS 449404 451803 - 2 400 799 FALSE

Rv0373c (Carbon monoxide dehydrogenase form I, large chain( EC: )) is predicted to be co-regulated in modules bicluster_0235 with residual 0.51 and bicluster_0283 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 240.00 for bicluster_0235 and 0.01 and 1.50 for bicluster_0283 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
PROBABLE CARBON MONOXYDE DEHYDROGENASE [LARGE CHAIN] carbon monoxyde dehydrogenase large subunit
Operon # Operon
253 - - - - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Nitrotoluene degradation

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Methane metabolism

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Microbial metabolism in diverse environments

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BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15607514 NP_214887.1 Run

carbon-monoxide dehydrogenase (acceptor) activity

carbon-monoxide dehydrogenase (acceptor) activity

Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor.
GO Category: 
Total items in this category:  

plasma membrane

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.580000 41.09

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: