Rv1084 Thymidylate kinase (EC

Product Feature Type Start End Strand Length AA Length is TF
Rv1084 Thymidylate kinase (EC CDS 1207636 1209657 + 2 022 673 FALSE

Rv1084 (Thymidylate kinase (EC is predicted to be co-regulated in modules bicluster_0156 with residual 0.52 and bicluster_0223 with residual 0.53.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 180.00 and 890.00 for bicluster_0156 and 0.00 and 9.50 for bicluster_0223 respectively.

These modules are enriched for following go terms: DNA modification.

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
Putative uncharacterized protein
Operon # Operon
729 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


dTMP kinase Pyrimidine metabolism
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608224 NP_215600.1 Run

thymidylate kinase activity

thymidylate kinase activity

Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate.
GO Category: 
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.000000 0.43

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: