Rv1216c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv1216c PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN CDS 1359472 1360146 - 675 224 FALSE

Rv1216c (PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN) is predicted to be co-regulated in modules bicluster_0011 with residual 0.41 and bicluster_0078 with residual 0.48.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 2.90 and 11.00 for bicluster_0011 and 360.00 and 14,000.00 for bicluster_0078 respectively.

These modules are enriched for following go terms: fatty acid synthase activity, transferase activity, transferring acyl ..., transferase activity, transferring acyl ... .

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN integral membrane protein
Operon # Operon
829 - - - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608356 NP_215732.1 Run
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.560000 1.05

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: