Rv1445c 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1445c devB 6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type CDS 1623714 1624457 - 744 247 FALSE

Rv1445c (6-phosphogluconolactonase (EC 3.1.1.31), eukaryotic type) is predicted to be co-regulated in modules bicluster_0444 with residual 0.53 and bicluster_0496 with residual 0.57.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 230.00 and 23,000.00 for bicluster_0444 and 0.00 and 0.00 for bicluster_0496 respectively.

These modules are enriched for following go terms: cellular component organization, cellular component biogenesis, cellular component organization or bioge... sulfur compound metabolic process.

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0444
e.value: 
230
Motif Bicluster: 
e.value: 
23000
Motif Bicluster: 
0.53
bicluster_0496
e.value: 
2.9e-38
Motif Bicluster: 
e.value: 
6.4e-27
Motif Bicluster: 
0.57
Product (LegacyBRC) Product (RefSeq)
6-phosphogluconolactonase 6-phosphogluconolactonase
Operon # Operon
965 Rv1444c - Rv1445c - Rv1446c
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

6-phosphogluconolactonase Pentose phosphate pathway
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Pentose phosphate pathway

19
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  

KEGG

Biosynthesis of secondary metabolites

326
Total items in this category:  

KEGG

Microbial metabolism in diverse environments

296
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608583 NP_215961.1 Run
GO:0017057

6-phosphogluconolactonase activity

6-phosphogluconolactonase activity

Details: 
Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+).
GO Category: 
molecular_function
1
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.790000 0.94

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.