Rv1477 NLP/P60 family protein

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1477 ripA NLP/P60 family protein FALSE

Rv1477 (NLP/P60 family protein) is predicted to be co-regulated in modules bicluster_0288 with residual 0.46 and bicluster_0393 with residual 0.48.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.23 and 2,800.00 for bicluster_0288 and 0.00 and 14.00 for bicluster_0393 respectively.

These modules are enriched for following go terms: cellular component biogenesis, cellular component organization or bioge..., carbohydrate binding, acid-amino acid ligase activity .

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 4 of 4
ChipSeq TF Differential Expression Distance Expression pvalue Type
Beta-carotene ketolase (EC 1.14.-.-)
No -32 -0.02 0.999473 Primary.TSS
DNA-binding response regulator mtrA
No -53 0.05 0.929738 Primary.TSS
DNA-binding response regulator TrcR
No -40 -0.52 0.00740155 Primary.TSS
Transcriptional regulator, ArsR family
No -35 0.07 0.716539 Primary.TSS
Motif 1 Motif 2 Residual
bicluster_0288
e.value: 
0.23
Motif Bicluster: 
e.value: 
2800
Motif Bicluster: 
0.46
bicluster_0393
e.value: 
0.00043
Motif Bicluster: 
e.value: 
14
Motif Bicluster: 
0.48
Product (LegacyBRC) Product (RefSeq)
invasion protein
Operon # Operon
984 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608615 NP_215993.1 Run
GO:0005515

protein binding

protein binding

Details: 
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO Category: 
molecular_function
135
Total items in this category:  
GO:0005576

extracellular region

extracellular region

Details: 
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO Category: 
cellular_component
272
Total items in this category:  
GO:0005618

cell wall

cell wall

Details: 
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan.
GO Category: 
cellular_component
320
Total items in this category:  
GO:0008745

N-acetylmuramoyl-L-alanine amidase activity

N-acetylmuramoyl-L-alanine amidase activity

Details: 
Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides.
GO Category: 
molecular_function
2
Total items in this category:  
GO:0040007

growth

growth

Details: 
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
biological_process
621
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: