Rv1553 Succinate dehydrogenase iron-sulfur protein (EC 1.3.99.1)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1553 frdB Succinate dehydrogenase iron-sulfur protein (EC 1.3.99.1) CDS 1759435 1760178 + 744 247 FALSE

Rv1553 (Succinate dehydrogenase iron-sulfur protein (EC 1.3.99.1)) is predicted to be co-regulated in modules bicluster_0429 with residual 0.52 and bicluster_0547 with residual 0.53.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 1.40 and 2,100.00 for bicluster_0429 and 0.00 and 19.00 for bicluster_0547 respectively.

These modules are enriched for following go terms: transferase activity, transferring one-c... .

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

BASS Score Re-Annotated Start Tuberculist Annotated Start
-0.267 1759438 1759435
Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulator, AraC family
No 54 -0.08 0.973088 CDS
Motif 1 Motif 2 Residual
bicluster_0429
e.value: 
1.4
Motif Bicluster: 
e.value: 
2100
Motif Bicluster: 
0.52
bicluster_0547
e.value: 
0.00012
Motif Bicluster: 
e.value: 
19
Motif Bicluster: 
0.53
Product (LegacyBRC) Product (RefSeq)
Fumarate reductase iron-sulfur subunit fumarate reductase iron-sulfur subunit FrdB
Operon # Operon
1033 Rv1552 - Rv1553 - Rv1554 - Rv1555
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Citrate cycle (TCA cycle)

35
Total items in this category:  

KEGG

Oxidative phosphorylation

47
Total items in this category:  

KEGG

Toluene degradation

13
Total items in this category:  

KEGG

Butanoate metabolism

63
Total items in this category:  

KEGG

Carbon fixation pathways in prokaryotes

42
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  

KEGG

Biosynthesis of secondary metabolites

326
Total items in this category:  

KEGG

Microbial metabolism in diverse environments

296
Total items in this category:  

KEGG

Two-component system

53
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608691 NP_216069.1 Run
GO:0000104

succinate dehydrogenase activity

succinate dehydrogenase activity

Details: 
Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor.
GO Category: 
molecular_function
7
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.120000 1.28

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.