Rv1830

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv1830 CDS 2074841 2075518 + 678 225 FALSE

Rv1830 () is predicted to be co-regulated in modules bicluster_0161 with residual 0.58 and bicluster_0356 with residual 0.59.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 1,500.00 and 11,000.00 for bicluster_0161 and 0.00 and 0.00 for bicluster_0356 respectively.

These modules are enriched for following go terms: purine-containing compound biosynthetic ... .

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

BASS Score Distance to Tuberculist Start Codon Internal TSS New Primary UTR Primary TSS Re-Annotated Start Tuberculist Annotated Start
-1.153 640 2075481 80 2074806 2074886 2074841
Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulator, ArsR family
Repressed -50 -1.13 7.21e-40 Primary.TSS
Motif 1 Motif 2 Residual
bicluster_0161
e.value: 
1500
Motif Bicluster: 
e.value: 
11000
Motif Bicluster: 
0.58
bicluster_0356
e.value: 
1.8e-24
Motif Bicluster: 
e.value: 
1.4e-21
Motif Bicluster: 
0.59
Product (LegacyBRC) Product (RefSeq)
Uncharacterized HTH-type transcriptional regulator Rv1830_MT1879
Operon # Operon
1201 Rv1830
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics
Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608967 NP_216346.1 Run
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
BioProject Accession GEO Series References Repository Sample Method Sample Type
PRJNA254351 GSM1426732 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426733 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426734 GSE59086 25232098 GEO Tiling Array RNA
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.