Rv2358 Transcriptional regulator, ArsR family

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2358 smtB Transcriptional regulator, ArsR family CDS 2641246 2641653 + 408 135 FALSE

Rv2358 (Transcriptional regulator, ArsR family) is predicted to be co-regulated in modules bicluster_0335 with residual 0.58 and bicluster_0482 with residual 0.61.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 57.00 and 1,600.00 for bicluster_0335 and 0.02 and 0.93 for bicluster_0482 respectively.

These modules are enriched for following go terms: cellular macromolecule biosynthetic proc..., macromolecule biosynthetic process, macromolecule metabolic process, cytoplasm.

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 3 of 3
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulator, AsnC family
No -104 -0.11 0.949904 CDS
transcriptional regulator, ArsR family
Induced -46 1.28 0.000000000481 CDS
Transcriptional regulator, TetR family
No -66 -0.47 0.292503 CDS
Motif 1 Motif 2 Residual
bicluster_0335
e.value: 
57
Motif Bicluster: 
e.value: 
1600
Motif Bicluster: 
0.58
bicluster_0482
e.value: 
0.019
Motif Bicluster: 
e.value: 
0.93
Motif Bicluster: 
0.61
Product (LegacyBRC) Product (RefSeq)
PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN [PROBABLY ARSR-FAMILY] ArsR family transcriptional regulator
Operon # Operon
1560 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15609495 NP_216874.1 Run
GO:0010043

response to zinc ion

response to zinc ion

Details: 
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
GO Category: 
biological_process
2
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: