Rv3133c Two component transcriptional regulatory protein DevR

Rv3133c (Two component transcriptional regulatory protein DevR) is predicted to be co-regulated in modules bicluster_0182 with residual 0.43 and bicluster_0417 with residual 0.42.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.32 for bicluster_0182 and 0.00 and 0.00 for bicluster_0417 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 121 - 130 of 151
Gene Target Differential Expression Distance Expression pvalue Type
Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
No -126 -0.33 0.0237177 Primary.TSS
Glucose/sorbosone dehydrogenase, lipoprotein LppZ
No -99 0.07 0.433475 Primary.TSS
Wax ester synthase/acyl-CoA:diacylglycerol acyltransferase
No 59 0.27 0.459484 CDS
Thiosulfate sulfurtransferase, rhodanese (EC 2.8.1.1)
No 38 0.08 0.631615 CDS
PPE family protein
Induced 62 1.13 0.0000000000000619 Primary.TSS
Induced -33 0.84 0.00000171 CDS
Induced 62 0.84 0.00000171 Internal.TSS
Oxygen-insensitive NADPH nitroreductase (EC 1.-.-.-)
Induced -44 4.65 2.65e-29 Primary.TSS
Wax ester synthase/acyl-CoA:diacylglycerol acyltransferase
Induced 32 5.53 4.53e-21 Primary.TSS
Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2
Induced -70 4.71 1.4e-19 Primary.TSS
not assigned to any KEGG Pathway.
GO:0008150

biological_process

biological_process

Details: 
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO Category: 
biological_process
66
Total items in this category:  
GO:0001666

response to hypoxia

response to hypoxia

Details: 
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
GO Category: 
biological_process
37
Total items in this category:  
GO:0003677

DNA binding

DNA binding

Details: 
Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).
GO Category: 
molecular_function
37
Total items in this category:  
GO:0003700

sequence-specific DNA binding transcription factor activity

sequence-specific DNA binding transcription factor activity

Details: 
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
GO Category: 
molecular_function
17
Total items in this category:  
GO:0005829

cytosol

cytosol

Details: 
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO Category: 
cellular_component
371
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0009405

pathogenesis

pathogenesis

Details: 
The set of specific processes that generate the ability of an organism to cause disease in another.
GO Category: 
biological_process
65
Total items in this category:  
GO:0045893

positive regulation of transcription, DNA-dependent

positive regulation of transcription, DNA-dependent

Details: 
Any process that activates or increases the frequency, rate or extent of cellular DNA-dependent transcription.
GO Category: 
biological_process
14
Total items in this category:  
GO:0071500

cellular response to nitrosative stress

cellular response to nitrosative stress

Details: 
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
GO Category: 
biological_process
14
Total items in this category:  
No TFOE experiment results were found

TRIP log2 fold abundance change

NA
Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D0U 27 0 0.00 14.12 U
D3I 3 3 3.83 14.30 I
D3U 3 3 3.83 14.27 U
D5I 9 5 6.00 12.47 I
D5U 17 5 6.00 13.00 U
D7I 18 7 8.14 12.94 I
D7U 19 7 8.14 14.46 U
D14I 4 14 15.63 10.33 I
D14U 4 14 15.63 14.09 U
D17I 3 17 19.15 7.28 I
D17U 3 17 19.15 13.81 U
D21I 4 21 23.23 6.55 I
D21U 4 21 23.23 13.76 U
D24I 3 24 26.60 3.76 I
D24U 3 24 26.60 13.46 U
D28I 4 28 30.61 6.20 I
D28U 4 28 30.61 13.30 U