Rv3246c DNA-binding response regulator mtrA

Rv3246c (DNA-binding response regulator mtrA) is predicted to be co-regulated in modules bicluster_0316 with residual 0.52 and bicluster_0393 with residual 0.48.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.49 and 70.00 for bicluster_0316 and 0.00 and 14.00 for bicluster_0393 respectively.

These modules are enriched for following go terms: nucleotide biosynthetic process, nucleoside phosphate biosynthetic proces..., nucleotide metabolic process, hydroxymethyl-, formyl- and related tran... .

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 31 - 40 of 82
Gene Target Differential Expression Distance Expression pvalue Type
(MTV005.05c), len: 100. similar to the N-terminal region of the M. tuberculosis PE family of proteinseg. TR:O05297 (EMBL:Z93777) MTCI364.07 (99 aa), fasta scores; opt: 209 z-score: 407.6 E(): 1.6e-15, 37.4% identityin 99 aa overlap. Also simlar to the N-terminus of M. tuberculosis TR:P77909 (EMBL:U76006) ESTERASE/LIPASE (EC 3.1.1.3) (TRIACYLGLYCEROL LIPASE) (437 aa), fasta scores; opt: 193z-score: 381.8 E(): 4.4e-14, 37.2% identity in 94 aa overlap. Contains a helix-turn-heix motiffrom aa 88-109(+2.76 SD)
No 22 -0.86 0.527113 Primary.TSS
N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB
No -63 -0.22 0.728639 CDS
No 63 0.06 0.947034 CDS
No -68 0.38 0.624947 Primary.TSS
Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)
No -61 0.45 0.517548 Primary.TSS
NLP/P60 family protein
No -53 0.05 0.929738 Primary.TSS
Putative membrane protein MmpL12
No 60 -0.03 0.973968 Primary.TSS
Probable methyltransferase (EC 2.1.1.-)
No 19 0.01 0.995946 CDS
Lipoprotein LprJ
No -41 0.73 0.283443 Primary.TSS
No -81 0.77 0.430569 CDS
not assigned to any KEGG Pathway.
GO:0008150

biological_process

biological_process

Details: 
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO Category: 
biological_process
66
Total items in this category:  
GO:0008150

biological_process

biological_process

Details: 
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO Category: 
biological_process
66
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0006468

protein phosphorylation

protein phosphorylation

Details: 
The process of introducing a phosphate group on to a protein.
GO Category: 
biological_process
2
Total items in this category:  
GO:0044117

growth of symbiont in host

growth of symbiont in host

Details: 
The increase in size or mass of an organism, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO Category: 
biological_process
36
Total items in this category:  
GO:0045893

positive regulation of transcription, DNA-dependent

positive regulation of transcription, DNA-dependent

Details: 
Any process that activates or increases the frequency, rate or extent of cellular DNA-dependent transcription.
GO Category: 
biological_process
14
Total items in this category:  
No TFOE experiment results were found
TRIP log2 fold abundance change
NA
Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D28I 4 28 30.61 13.07 I
D28U 4 28 30.61 12.83 U
D24U 3 24 26.60 13.07 U
D24I 3 24 26.60 12.96 I
D21I 4 21 23.23 13.56 I
D21U 4 21 23.23 13.32 U
D17I 3 17 19.15 13.69 I
D17U 3 17 19.15 13.48 U
D14I 4 14 15.63 13.86 I
D14U 4 14 15.63 13.31 U
D7I 18 7 8.14 13.33 I
D7U 19 7 8.14 13.14 U
D5I 9 5 6.00 13.63 I
D5U 17 5 6.00 13.32 U
D3I 3 3 3.83 13.01 I
D3U 3 3 3.83 13.45 U
D0U 27 0 0.00 13.04 U