Rv3324c Molybdenum cofactor biosynthesis protein MoaC

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3324c moaC Molybdenum cofactor biosynthesis protein MoaC CDS 3709715 3710269 - 555 184 FALSE

Rv3324c (Molybdenum cofactor biosynthesis protein MoaC) is predicted to be co-regulated in modules bicluster_0204 with residual 0.42 and bicluster_0561 with residual 0.52.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 6.20 for bicluster_0204 and 0.03 and 9.50 for bicluster_0561 respectively.

These modules are enriched for following go terms: Mo-molybdopterin cofactor biosynthetic p..., Mo-molybdopterin cofactor metabolic proc..., molybdopterin cofactor biosynthetic proc..., molybdopterin cofactor metabolic process, prosthetic group metabolic process monovalent inorganic cation transport, metal ion transport, cation-transporting ATPase activity, metal ion transmembrane transporter acti..., monovalent inorganic cation transmembran..., ATPase activity, coupled to transmembran....

This gene is found to be for growth on cholesterol.

Mutant available?:

BASS Score Re-Annotated Start Tuberculist Annotated Start
-0.682 3710227 3710248
Product (LegacyBRC) Product (RefSeq)
Molybdenum cofactor biosynthesis protein C 3 molybdenum cofactor biosynthesis protein C
Operon # Operon
2169 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Sulfur relay system

18
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
161352462 NP_217841.2 Run
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.280000 0.92

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: