Rv3331 Sugar-transport integral membrane proteinSugI

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3331 sugI Sugar-transport integral membrane proteinSugI CDS 3717090 3718598 + 1 509 502 FALSE

Rv3331 (Sugar-transport integral membrane proteinSugI) is predicted to be co-regulated in modules bicluster_0024 with residual 0.54 and bicluster_0379 with residual 0.53.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 1.30 and 1.50 for bicluster_0024 and 8.60 and 9.10 for bicluster_0379 respectively.

These modules are enriched for following go terms: NAD(P)+ transhydrogenase activity, oxidoreductase activity, acting on NAD(P....

This gene is found to be non-essential for growth on cholesterol.

Mutant available?: Yes

BASS Score Re-Annotated Start Tuberculist Annotated Start
-0.722 3717315 3717090
Last update: 10/16/2017 - 15:27
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-14905 MT3434 212
Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0024
e.value: 
1.3
Motif Bicluster: 
e.value: 
1.5
Motif Bicluster: 
0.54
bicluster_0379
e.value: 
8.6
Motif Bicluster: 
e.value: 
9.1
Motif Bicluster: 
0.53
Product (LegacyBRC) Product (RefSeq)
PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN SUGI sugar-transport integral membrane protein SugI
Operon # Operon
2176 Rv3331 - Rv3332
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15610467 NP_217848.1 Run
GO:0005365

myo-inositol transmembrane transporter activity

myo-inositol transmembrane transporter activity

Details: 
Catalysis of the transfer of myo-inositol from one side of the membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms.
GO Category: 
molecular_function
1
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.150000 0.85

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.