Rv3422c ATPase YjeE, predicted to have essential role in cell wall biosynthesis

Product Feature Type Start End Strand Length AA Length is TF
Rv3422c ATPase YjeE, predicted to have essential role in cell wall biosynthesis CDS 3839691 3840197 - 507 168 FALSE

Rv3422c (ATPase YjeE, predicted to have essential role in cell wall biosynthesis) is predicted to be co-regulated in modules bicluster_0087 with residual 0.55 and bicluster_0460 with residual 0.59.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 590.00 and 1,300.00 for bicluster_0087 and 55.00 and 160.00 for bicluster_0460 respectively.

These modules are enriched for following go terms: branched-chain amino acid metabolic proc..., translation, acetolactate synthase activity, anion transmembrane-transporting ATPase ..., structural constituent of ribosome.

This gene is found to be for growth on cholesterol.

Mutant available?:

Product (LegacyBRC) Product (RefSeq)
UPF0079 ATP-binding protein Rv3422c_MT3531
Operon # Operon
2237 - - - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15610558 NP_217939.1 Run



The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.500000 0.09

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: