Rv3535c Acetaldehyde dehydrogenase, acetylating, (EC 1.2.1.10) in gene cluster for degradation of phenols, cresols, catechol

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3535c hsaG Acetaldehyde dehydrogenase, acetylating, (EC 1.2.1.10) in gene cluster for degradation of phenols,... CDS 3973589 3974500 - 912 303 FALSE

Rv3535c (Acetaldehyde dehydrogenase, acetylating, (EC 1.2.1.10) in gene cluster for degradation of phenols, cresols, catechol) is predicted to be co-regulated in modules bicluster_0199 with residual 0.54 and bicluster_0337 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.00 for bicluster_0199 and 0.00 and 0.00 for bicluster_0337 respectively.

These modules are enriched for following go terms: aspartate carbamoyltransferase activity.

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulator, TetR family
No -130 0.6 0.273056 CDS
Motif 1 Motif 2 Residual
bicluster_0199
e.value: 
0.000000000000001
Motif Bicluster: 
e.value: 
0.000000085
Motif Bicluster: 
0.54
bicluster_0337
e.value: 
1.2e-19
Motif Bicluster: 
e.value: 
0.000000026
Motif Bicluster: 
0.50
Product (LegacyBRC) Product (RefSeq)
PROBABLE ACETALDEHYDE DEHYDROGENASE [ACETALDEHYDE DEHYDROGENASE [ACETYLATING]] acetaldehyde dehydrogenase
Operon # Operon
2309 Rv3534c - Rv3535c - Rv3536c
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Benzoate degradation

48
Total items in this category:  

KEGG

Pyruvate metabolism

40
Total items in this category:  

KEGG

Dioxin degradation

5
Total items in this category:  

KEGG

Xylene degradation

4
Total items in this category:  

KEGG

Butanoate metabolism

63
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  

KEGG

Microbial metabolism in diverse environments

296
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15610671 NP_218052.1 Run
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.020000 0.32

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.