Organism : Rhodobacter sphaeroides 2.4.1 | Module List :
Deoxyguanosinetriphosphate triphosphohydrolase-like protein (NCBI)
Functional Annotations (6)
|dGTP triphosphohydrolase||cog/ cog|
|magnesium ion binding||go/ molecular_function|
|dGTPase activity||go/ molecular_function|
|GTP metabolic process||go/ biological_process|
|Purine metabolism||kegg/ kegg pathway|
Regulation information for RSP_1621(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for RSP_1621
Module neighborhood information for RSP_1621
|Gene||Common Name||Description||Module membership|
|RSP_0002||spbB||Histone-like nucleoid-structuring protein H-NS (NCBI)||48, 93|
|RSP_0146||glnB||Nitrogen regulatory protein P-II (NCBI)||93, 108|
|RSP_0147||glnA||Glutamine synthetase class-I (NCBI)||25, 93|
|RSP_0223||RSP_0223||hypothetical protein (NCBI)||93, 358|
|RSP_0224||RSP_0224||ATP-dependent helicase (NCBI)||93, 358|
|RSP_0282||ppsR||Transcriptional regulator, PpsR (NCBI)||358, 381|
|RSP_0384||RSP_0384||hypothetical protein (NCBI)||329, 381|
|RSP_0415||RSP_0415||sigma-24 (NCBI)||308, 381|
|RSP_0452||recA||Recombinase A, DNA recombination protein (NCBI)||30, 93|
|RSP_0599||RSP_0599||Probable DNA/pantothenate metabolism flavoprotein (NCBI)||242, 381|
|RSP_0708||RSP_0708||NUDIX hydrolase (NCBI)||242, 381|
|RSP_0710||dnaX||DNA polymerase III tau and gamma subunits (NCBI)||173, 381|
|RSP_0797||gltX-1||Glutamyl-tRNA synthetase, class Ic (NCBI)||51, 93|
|RSP_0831||trpA||Tryptophan synthase, alpha chain (NCBI)||51, 93|
|RSP_0981||RSP_0981||Transcriptional regulator, GntR family (NCBI)||93, 277|
|RSP_0982||RSP_0982||zinc metallopeptidases-like protein (NCBI)||93, 277|
|RSP_0983||RSP_0983||hypothetical protein (NCBI)||93, 277|
|RSP_1085||RSP_1085||hypothetical protein (NCBI)||75, 93|
|RSP_1188||wcaG||Nucleotide sugar epimerase/dehydratase (NCBI)||59, 381|
|RSP_1214||RSP_1214||putative branched-chain amino acid aminotransferase (NCBI)||215, 381|
|RSP_1215||ilvE||putative IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase (NCBI)||68, 381|
|RSP_1342||dnaA||chromosomal replication initiator protein, DnaA (NCBI)||25, 381|
|RSP_1360||RSP_1360||hypothetical protein (NCBI)||30, 93|
|RSP_1404||RSP_1404||Orotidine 5'-phosphate decarboxylase (NCBI)||311, 381|
|RSP_1405||RSP_1405||ROK family protein (NCBI)||285, 381|
|RSP_1459||RSP_1459||hypothetical protein (NCBI)||93, 279|
|RSP_1460||RSP_1460||hypothetical protein (NCBI)||71, 93|
|RSP_1520||prrB||Sensor histidine kinase PrrB (RegB) (NCBI)||16, 381|
|RSP_1553||RSP_1553||Probable glyoxylate induced protein (NCBI)||102, 381|
|RSP_1554||RSP_1554||Possible polysaccharide deacetylase (NCBI)||102, 381|
|RSP_1555||RSP_1555||Transthyretin-like protein (NCBI)||329, 381|
|RSP_1566||RSP_1566||hypothetical protein (NCBI)||176, 381|
|RSP_1621||RSP_1621||Deoxyguanosinetriphosphate triphosphohydrolase-like protein (NCBI)||93, 381|
|RSP_1622||RSP_1622||Putative DNA-binding protein (NCBI)||93, 208|
|RSP_1623||RSP_1623||hypothetical protein (NCBI)||93, 130|
|RSP_1894||RSP_1894||hypothetical protein (NCBI)||323, 381|
|RSP_1908||RSP_1908||outer membrane protein, OmpA/MotB family (NCBI)||72, 381|
|RSP_1909||RSP_1909||Outer membrane general secretion pathway protein, Secretin (NCBI)||221, 381|
|RSP_1946||RSP_1946||Cytochrome P450 hydroxylase (NCBI)||175, 381|
|RSP_1977||cobS||cobalt chelatase, CobS small subunit (NCBI)||93, 261|
|RSP_1978||RSP_1978||molecular chaperone, DnaJ family (NCBI)||93, 261|
|RSP_1979||RSP_1979||stress induced morphogen, BolA (NCBI)||93, 261|
|RSP_1997||lexA||LexA repressor (NCBI)||30, 93|
|RSP_2119||RSP_2119||hypothetical protein (NCBI)||10, 381|
|RSP_2246||hisB||Imidazoleglycerol-phosphate dehydratase (NCBI)||93, 182|
|RSP_2329||mreB||Cell shape determining protein MreB/Mrl (NCBI)||93, 309|
|RSP_2356||RSP_2356||hypothetical protein (NCBI)||93, 114|
|RSP_2361||RSP_2361||putative integrase/resolvase recombinase protein phage-related integrase (NCBI)||93, 161|
|RSP_2624||RSP_2624||hypothetical protein (NCBI)||30, 93|
|RSP_2694||RSP_2694||hypothetical protein (NCBI)||357, 381|
|RSP_2869||RSP_2869||Possible tellurite resistance protein (NCBI)||329, 381|
|RSP_2882||RSP_2882||two component transcriptional regulator, LuxR family (NCBI)||62, 381|
|RSP_2942||RSP_2942||hypothetical protein (NCBI)||349, 381|
|RSP_3003||RSP_3003||hypothetical protein (NCBI)||93, 108|
|RSP_3226||RSP_3226||Silent information regulator protein, Sir2 (NCBI)||99, 381|
|RSP_3376||aroQ||3 dehydroquinase dehydratase, class II (NCBI)||240, 381|
|RSP_3419||RSP_3419||hypothetical protein (NCBI)||175, 381|
|RSP_3507||RSP_3507||hypothetical protein (NCBI)||381, 384|
|RSP_3553||dnaE||DNA polymerase III alpha chain (NCBI)||291, 381|
|RSP_3644||RSP_3644||Metal dependent phosphohydrolase (NCBI)||93, 130|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
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For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.
Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
- 4. Interactions between source and target genes for a particular module
- 5. Module(s) that source gene and target genes belong to
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