Organism : Bacillus subtilis | Module List :
BSU18410 ggt

membrane bound gamma-glutamyltranspeptidase (RefSeq)

CircVis
Functional Annotations (9)
Function System
Gamma-glutamyltransferase cog/ cog
gamma-glutamyltransferase activity go/ molecular_function
Taurine and hypotaurine metabolism kegg/ kegg pathway
Selenocompound metabolism kegg/ kegg pathway
Cyanoamino acid metabolism kegg/ kegg pathway
Glutathione metabolism kegg/ kegg pathway
Arachidonic acid metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
g_glut_trans tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU18410
(Mouseover regulator name to see its description)

BSU18410 is regulated by 17 influences and regulates 0 modules.
Regulators for BSU18410 ggt (17)
Regulator Module Operator
BSU01690 19 tf
BSU15320 19 tf
BSU15970 19 tf
BSU16600 19 tf
BSU19090 19 tf
BSU24320 19 tf
BSU29270 19 tf
BSU29630 19 tf
BSU30020 19 tf
BSU04770 12 tf
BSU08190 12 tf
BSU15320 12 tf
BSU19030 12 tf
BSU23450 12 tf
BSU29630 12 tf
BSU35910 12 tf
BSU38070 12 tf

Warning: BSU18410 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4986 8.10e-03 AGGAGggA
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4987 3.00e+03 tTgTggaaAAc
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5000 1.10e-02 AGGaGGgA
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5001 1.10e+02 GCc.GCTGCtacag.c.GgCGC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU18410

BSU18410 is enriched for 9 functions in 3 categories.
Enrichment Table (9)
Function System
Gamma-glutamyltransferase cog/ cog
gamma-glutamyltransferase activity go/ molecular_function
Taurine and hypotaurine metabolism kegg/ kegg pathway
Selenocompound metabolism kegg/ kegg pathway
Cyanoamino acid metabolism kegg/ kegg pathway
Glutathione metabolism kegg/ kegg pathway
Arachidonic acid metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
g_glut_trans tigr/ tigrfam
Module neighborhood information for BSU18410

BSU18410 has total of 38 gene neighbors in modules 12, 19
Gene neighbors (38)
Gene Common Name Description Module membership
BSU01680 ybbF putative sugar phosphotransferase enzyme II (RefSeq) 19, 407
BSU07830 yfkO NAD(P)H-flavin oxidoreductase (RefSeq) 19, 161
BSU12430 rapA response regulator aspartate phosphatase (RefSeq) 12, 19
BSU12440 phrA secreted inhibitor of the activity of phosphatase RapA (RefSeq) 12, 19
BSU15300 bpr bacillopeptidase F (RefSeq) 12, 306
BSU15310 spoIIGA protease processing pro-sigma-E (RefSeq) 12, 184
BSU15320 sigE sporulation sigma factor SigE (RefSeq) 12, 184
BSU17000 kbl 2-amino-3-ketobutyrate coenzyme A ligase (RefSeq) 12, 186
BSU17600 xylA xylose isomerase (RefSeq) 19, 241
BSU17610 xylB xylulose kinase (RefSeq) 19, 405
BSU18410 ggt membrane bound gamma-glutamyltranspeptidase (RefSeq) 12, 19
BSU18660 yoaM hypothetical protein (RefSeq) 19, 150
BSU19030 yobO putative phage-related pre-neck appendage protein (RefSeq) 12, 353
BSU22550 qcrB cytochrome b6 (RefSeq) 12, 210
BSU22560 qcrA menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit) (RefSeq) 12, 210
BSU23450 sigF sporulation sigma factor SigF (RefSeq) 12, 184
BSU23460 spoIIAB anti-sigma F factor (RefSeq) 12, 184
BSU23470 spoIIAA anti-anti-sigma factor (antagonist of SpoIIAB) (RefSeq) 12, 184
BSU26640 yrdP putative oxidoreductase (RefSeq) 19, 161
BSU26650 czcD potassium/proton-divalent cation antiporter (RefSeq) 19, 161
BSU29630 yttP putative transcriptional regulator (RefSeq) 12, 141
BSU33120 liaH modulator of liaIHGFSR (yvqIHGFEC) operon expression (RefSeq) 19, 49
BSU33130 liaI permease (RefSeq) 19, 115
BSU35540 tuaH putative glycosyltransferase (RefSeq) 19, 349
BSU35550 tuaG putative glycosyltransferase (RefSeq) 19, 349
BSU35560 tuaF putative hydrolase involved in teichuronic acid synthesis (RefSeq) 19, 349
BSU35570 tuaE putative polymerase of teichuronic acid repeating units (RefSeq) 19, 349
BSU35580 tuaD UDP-glucose 6-dehydrogenase (RefSeq) 19, 349
BSU35590 tuaC putative glycosyltransferase (RefSeq) 19, 349
BSU38070 sacT transcriptional antiterminator (RefSeq) 12, 323
BSU38080 ywcI hypothetical protein (RefSeq) 12, 184
BSU38090 vpr extracellular serine protease (RefSeq) 19, 101
BSU38130 ywcE protein required for proper spore morphogenesis and germination (RefSeq) 12, 217
BSU38340 ywbF putative sugar permease (RefSeq) 19, 150
BSU39880 yxbC hypothetical protein (RefSeq) 12, 19
BSU39890 yxbB putative S-adenosylmethionine-dependent methyltransferase (RefSeq) 19, 141
BSU39900 aslA D-Aspartate ligase (RefSeq) 12, 19
BSU39910 yxnB hypothetical protein (RefSeq) 19, 141
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU18410
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend