Organism : Bacillus subtilis | Module List :
BSU18840 xynA

endo-1,4-beta-xylanase (RefSeq)

CircVis
Functional Annotations (4)
Function System
carbohydrate metabolic process go/ biological_process
endo-1,4-beta-xylanase activity go/ molecular_function
negative regulation of endo-1,4-beta-xylanase activity go/ biological_process
positive regulation of endo-1,4-beta-xylanase activity go/ biological_process
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU18840
(Mouseover regulator name to see its description)

BSU18840 is regulated by 28 influences and regulates 0 modules.
Regulators for BSU18840 xynA (28)
Regulator Module Operator
BSU04650 128 tf
BSU05050 128 tf
BSU05320 128 tf
BSU06860 128 tf
BSU07590 128 tf
BSU14740 128 tf
BSU15640 128 tf
BSU15970 128 tf
BSU16470 128 tf
BSU16900 128 tf
BSU19100 128 tf
BSU23090 128 tf
BSU25250 128 tf
BSU25760 128 tf
BSU27320 128 tf
BSU28820 128 tf
BSU36420 128 tf
BSU38700 128 tf
BSU38910 128 tf
BSU05420 213 tf
BSU12560 213 tf
BSU14740 213 tf
BSU16900 213 tf
BSU19100 213 tf
BSU24220 213 tf
BSU25250 213 tf
BSU25490 213 tf
BSU39850 213 tf

Warning: BSU18840 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5208 3.10e+01 a.gaAAaAgag
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5209 1.90e+02 GGgGGTgAaA
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5370 4.20e+01 CGGaaTctgaGGcAG
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5371 6.30e+02 taCctct.tTaatatgacaccTct
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU18840

BSU18840 is enriched for 4 functions in 2 categories.
Enrichment Table (4)
Function System
carbohydrate metabolic process go/ biological_process
endo-1,4-beta-xylanase activity go/ molecular_function
negative regulation of endo-1,4-beta-xylanase activity go/ biological_process
positive regulation of endo-1,4-beta-xylanase activity go/ biological_process
Module neighborhood information for BSU18840

BSU18840 has total of 43 gene neighbors in modules 128, 213
Gene neighbors (43)
Gene Common Name Description Module membership
BSU00480 yabJ putative enzyme resulting in alteration of gene expression (RefSeq) 128, 221
BSU04250 lrpC transcriptional regulator (Lrp/AsnC family) (RefSeq) 22, 213
BSU04290 ydaL hypothetical protein (RefSeq) 44, 213
BSU04310 ydaN putative regulator (RefSeq) 44, 213
BSU05280 ydeO putative integral inner membrane protein (RefSeq) 128, 378
BSU06010 ydiL putative membrane protease (RefSeq) 39, 128
BSU06110 ydjA BsuM intrinsic DNA restriction component (RefSeq) 128, 199
BSU06250 ydjM hypothetical protein (RefSeq) 40, 213
BSU06260 ydjN hypothetical protein (RefSeq) 40, 213
BSU09110 yhcJ putative ABC transporter (binding lipoprotein) (RefSeq) 128, 167
BSU09910 yhaO putative exonuclease (RefSeq) 213, 284
BSU09920 yhaN putative ATPase involved in DNA metabolism (RefSeq) 213, 389
BSU10060 ecsC putative hydrolase (RefSeq) 213, 341
BSU10090 yhgB hypothetical protein (RefSeq) 87, 213
BSU14190 dapL N-acetyl-diaminopimelate deacetylase (RefSeq) 128, 313
BSU14260 mobA molybdopterin-guanine dinucleotide biosynthesis protein A (RefSeq) 128, 243
BSU14310 moaD molybdopterin synthase (small subunit) (RefSeq) 128, 150
BSU14610 pdhD dihydrolipoamide dehydrogenase (RefSeq) 128, 355
BSU14640 yktA hypothetical protein (RefSeq) 213, 316
BSU14790 ylaI hypothetical protein (RefSeq) 128, 324
BSU17680 thyA thymidylate synthase (RefSeq) 128, 255
BSU17890 tkt transketolase (RefSeq) 128, 273
BSU18840 xynA endo-1,4-beta-xylanase (RefSeq) 128, 213
BSU19210 yocH putative exported cell wall-binding protein (RefSeq) 40, 213
BSU22080 ypwA metal-dependent carboxypeptidase (RefSeq) 128, 199
BSU22790 hbs non-specific DNA-binding protein HBsu; signal recognition particle-like (SRP) component (RefSeq) 128, 197
BSU23070 serA D-3-phosphoglycerate dehydrogenase (RefSeq) 15, 128
BSU23080 aroD 3-dehydroquinate dehydratase (RefSeq) 128, 231
BSU23360 ppiB peptidyl-prolyl isomerase (RefSeq) 7, 128
BSU23510 xerD site-specific tyrosine recombinase XerD (RefSeq) 7, 128
BSU25550 rpsT 30S ribosomal protein S20 (RefSeq) 128, 197
BSU29250 nrnA oligoribonuclease (nanoRNAse), 3',5'-bisphosphate nucleotidase (RefSeq) 128, 324
BSU31440 patB C-S lyase (RefSeq) 11, 128
BSU32290 yutF putative p-nitrophenyl phosphatase (RefSeq) 213, 255
BSU32330 lipA lipoyl synthase (RefSeq) 116, 128
BSU32350 yunB putative protein involved in spore formation (RefSeq) 213, 217
BSU35220 minJ topological determinant of cell division (RefSeq) 87, 128
BSU35250 ftsX cell-division ABC transporter (RefSeq) 13, 128
BSU35640 lytA membrane bound lipoprotein (RefSeq) 7, 128
BSU35850 ywtE putative hydrolase (RefSeq) 128, 247
BSU36370 fabZ (3R)-hydroxymyristoyl-ACP dehydratase (RefSeq) 128, 245
BSU36900 glyA serine hydroxymethyltransferase (RefSeq) 128, 197
BSU39850 yxbF putative transcriptional regulator (RefSeq) 213, 291
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU18840
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend