Organism : Bacteroides thetaiotaomicron VPI-5482 | Module List :
NP_810935.1 BT_2022

None

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for NP_810935.1
(Mouseover regulator name to see its description)

Warning: No Regulators were found for NP_810935.1!

Warning: NP_810935.1 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
6196 1.10e-09 TcTccgcagC.gcgg..a.Tattg
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6197 3.90e+00 gttacaTCgtttcTCCg
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6482 8.70e-08 CcggtCGcttCGactccgCc
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6483 9.50e-01 gttgTTa.agccTGTatcc.gac
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for NP_810935.1

Warning: No Functional annotations were found!

Module neighborhood information for NP_810935.1

NP_810935.1 has total of 45 gene neighbors in modules 236, 385
Gene neighbors (45)
Gene Common Name Description Module membership
NP_808991.1 BT_0078 None 99, 236
NP_808992.1 BT_0079 None 45, 236
NP_808993.1 BT_0080 None 236, 283
NP_808994.1 BT_0081 None 45, 236
NP_809016.1 BT_0103 None 236, 470
NP_809017.1 BT_0104 None 236, 470
NP_809018.1 BT_0105 None 236, 470
NP_810905.1 BT_1992 None 36, 236
NP_810906.1 BT_1993 None 36, 236
NP_810934.1 BT_2021 None 236, 385
NP_810935.1 BT_2022 None 236, 385
NP_811195.1 BT_2282 None 121, 385
NP_811196.1 BT_2283 None 121, 385
NP_811197.1 BT_2284 None 121, 385
NP_811198.1 BT_2285 None 121, 385
NP_811199.1 BT_2286 None 121, 385
NP_811211.1 BT_2298 None 134, 385
NP_811212.1 BT_2299 None 134, 385
NP_811213.1 BT_2300 None 134, 385
NP_811214.1 BT_2301 None 134, 385
NP_811215.1 BT_2302 None 134, 385
NP_811216.1 BT_2303 None 134, 385
NP_811245.1 BT_2332 None 97, 385
NP_811246.1 BT_2333 None 97, 385
NP_811247.1 BT_2334 None 97, 385
NP_811427.1 BT_2514 None 236, 263
NP_811520.1 BT_2607 None 385, 453
NP_811521.1 BT_2608 None 385, 453
NP_811522.1 BT_2609 None 385, 453
NP_811553.1 BT_2640 None 190, 236
NP_811558.1 BT_2645 None 211, 385
NP_811559.1 BT_2646 None 36, 385
NP_811560.1 BT_2647 None 36, 385
NP_811561.1 BT_2648 None 36, 385
NP_811562.1 BT_2649 None 211, 385
NP_812778.1 BT_3867 None 62, 236
NP_812940.1 BT_4029 None 236, 441
NP_812944.1 BT_4033 None 97, 385
NP_813276.1 BT_4365 None 236, 453
NP_813352.1 BT_4441 None 236, 283
NP_813682.1 BT_4771 None 40, 236
NP_813683.1 BT_4772 None 40, 236
NP_813684.1 BT_4773 None 40, 236
NP_813685.1 BT_4774 None 40, 236
NP_813686.1 BT_4775 None 40, 236
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for NP_810935.1
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend