Organism : Clostridium acetobutylicum
| Module List :
CAC0290
Sensory transduction histidine kinases (NCBI ptt file)
Functional Annotations (6)
| Function | System |
|---|---|
| Signal transduction histidine kinase | cog/ cog |
| two-component sensor activity | go/ molecular_function |
| ATP binding | go/ molecular_function |
| signal transduction | go/ biological_process |
| membrane | go/ cellular_component |
| peptidyl-histidine phosphorylation | go/ biological_process |
Module member 
Regulator 
Motif
Regulation information for CAC0290
(Mouseover regulator name to see its description)
| Regulator | Module | Operator |
|---|---|---|
| CAC0191 | 82 | tf |
| CAC0201 | 82 | tf |
| CAC0569 | 82 | tf |
| CAC0841 | 82 | tf |
| CAC0849 | 82 | tf |
| CAC1467 | 82 | tf |
| CAC1559 | 82 | tf |
| CAC1578 | 82 | tf |
| CAC1766 | 82 | tf |
| CAC1869 | 82 | tf |
| CAC2060 | 82 | tf |
| CAC2084 | 82 | tf |
| CAC2690 | 82 | tf |
| CAC3037 | 82 | tf |
| CAC3192 | 82 | tf |
| CAC2143 | 91 | tf |
| CAC2297 | 91 | tf |
| CAC2476 | 91 | tf |
| CAC3166 | 91 | tf |
| CAC3361 | 91 | tf |
| CAC3729 | 91 | tf |
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
| Motif Id | e-value | Consensus | Motif Logo |
|---|---|---|---|
| 6818 | 3.00e-06 | GgAgGg |
 |
| 6819 | 8.90e+03 | CTGCTGC |
|
| 6836 | 7.00e-06 | AGGagggg |
|
| 6837 | 7.90e+03 | CTaGCCaCC |
|
Functional Enrichment for CAC0290
| Function | System |
|---|---|
| Signal transduction histidine kinase | cog/ cog |
| two-component sensor activity | go/ molecular_function |
| ATP binding | go/ molecular_function |
| signal transduction | go/ biological_process |
| membrane | go/ cellular_component |
| peptidyl-histidine phosphorylation | go/ biological_process |
Module neighborhood information for CAC0290
| Gene | Common Name | Description | Module membership |
|---|---|---|---|
| CAC0040 | CAC0040 | Uncharacterized small conserved protein, homolog of yfjA/yukE B.subtilis (NCBI ptt file) | 82, 251 |
| CAC0168 | CAC0168 | T-RNA-processing ribonuclease BN (NCBI ptt file) | 82, 207 |
| CAC0208 | CAC0208 | Predicted membrane protein; CF-20 family (NCBI ptt file) | 82, 302 |
| CAC0209 | CAC0209 | Predicted membrane protein; CF-20 family (NCBI ptt file) | 82, 366 |
| CAC0224 | CAC0224 | Response regulator (CheY-like receiver domain and HTH DNA-binding domain) (NCBI ptt file) | 3, 91 |
| CAC0229 | CAC0229 | Predicted Zn-dependent proteases, TLDD ortholog (NCBI ptt file) | 91, 225 |
| CAC0230 | CAC0230 | Inactivated predicted Zn-dependent protease, PMBA ortholog (NCBI ptt file) | 91, 225 |
| CAC0290 | CAC0290 | Sensory transduction histidine kinases (NCBI ptt file) | 82, 91 |
| CAC0386 | licC | PTS cellobiose-specific component IIC (NCBI ptt file) | 82, 285 |
| CAC0400 | CAC0400 | Hypothetical protein, CF-19 family (NCBI ptt file) | 91, 346 |
| CAC0539 | manB | Beta-mannanase ManB, contains ChW-repeats (NCBI ptt file) | 82, 251 |
| CAC0602 | ftsH | ATP-dependent zinc metallopeptidase FtsH (cell dividion protein) (NCBI ptt file) | 91, 222 |
| CAC0603 | CAC0603 | Superfamily I DNA and RNA helicase (NCBI ptt file) | 91, 225 |
| CAC0630 | CAC0630 | Peptide chain ralease factor 3 (RF-3) (NCBI ptt file) | 82, 160 |
| CAC0633 | CAC0633 | Predicted phosphatase (NCBI ptt file) | 82, 151 |
| CAC0764 | CAC0764 | NADPH-dependent glutamate synthase beta chain (NCBI ptt file) | 44, 91 |
| CAC0783 | CAC0783 | Uncharacterized low-complexity protein (NCBI ptt file) | 82, 251 |
| CAC0784 | CAC0784 | ATP-dependent RNA helicase, superfamily II (NCBI ptt file) | 82, 251 |
| CAC1540 | CAC1540 | Uncharacterized ATP-grasp enzyme (NCBI ptt file) | 71, 91 |
| CAC1544 | CAC1544 | Cytidine deaminase, cdd (NCBI ptt file) | 91, 225 |
| CAC1546 | deoA | Pyrimidine-nucleoside phosphorylase (NCBI ptt file) | 91, 200 |
| CAC1615 | CAC1615 | Predicted glycosyltransferase (NCBI ptt file) | 69, 82 |
| CAC1717 | CAC1717 | Uncharacterized conserved protein, YLOA ortholog (NCBI ptt file) | 3, 91 |
| CAC1796 | CAC1796 | Predicted membrane-associated Zn-dependent protease (NCBI ptt file) | 64, 91 |
| CAC2065 | deoB | Phosphopentomutase (NCBI ptt file) | 51, 91 |
| CAC2066 | CAC2066 | Integrase/recombinase XerD family (NCBI ptt file) | 51, 91 |
| CAC2174 | CAC2174 | Glycosyltransferase (NCBI ptt file) | 82, 346 |
| CAC2253 | CAC2253 | Membrane-associated sensory histidine kinase-like ATPase (NCBI ptt file) | 82, 106 |
| CAC2296 | CAC2296 | Uncharacterized protein, YigZ family (NCBI ptt file) | 3, 91 |
| CAC2297 | CAC2297 | Transcriptional regulator of MocR family (DNA-binding HTH domain and aminotransferase domain) (NCBI ptt file) | 3, 91 |
| CAC2298 | CAC2298 | Predicted nucleotidyltransferase (NCBI ptt file) | 91, 345 |
| CAC2323 | CAC2323 | Predicted membrane protein (NCBI ptt file) | 5, 82 |
| CAC2324 | CAC2324 | Glycosyltransferase (NCBI ptt file) | 82, 215 |
| CAC2338 | CAC2338 | Lysine decarboxylase (NCBI ptt file) | 82, 285 |
| CAC2340 | mutS1 | DNA mismatch repair protein mutS, YSHD B.subtilis ortholog (NCBI ptt file) | 51, 91 |
| CAC2415 | CAC2415 | Uncharacterized conserved protein (NCBI ptt file) | 91, 289 |
| CAC2432 | CAC2432 | Predicted permease (NCBI ptt file) | 82, 106 |
| CAC2601 | CAC2601 | S-adenosylmethionine decarboxylase (NCBI ptt file) | 82, 225 |
| CAC2736 | sbcC | ATPase involved in DNA repair (NCBI ptt file) | 91, 98 |
| CAC2912 | araN | Sugar-binding periplasmic protein (NCBI ptt file) | 82, 235 |
| CAC2913 | CAC2913 | Hypothetical protein (NCBI ptt file) | 82, 235 |
| CAC3212 | CAC3212 | Fusion of Uroporphyrinogen-III methylase related protein and MAZG family protein, YABN B.subtilis ortholog (NCBI ptt file) | 82, 302 |
| CAC3260 | asnS | Aspartyl/asparaginyl-tRNA synthetase (NCBI ptt file) | 82, 292 |
| CAC3299 | bdhA | NADH-dependent butanol dehydrogenase A (BDH I) (NCBI ptt file) | 91, 100 |
| CAC3392 | CAC3392 | NADH-dependent butanol dehydrogenase (NCBI ptt file) | 62, 91 |
| CAC3571 | fabZ | Hydroxymyristoyl-(acyl carrier protein) dehydratase (NCBI ptt file) | 65, 91 |
| CAC3572 | accB | Biotin carboxyl carrier protein of acetyl-CoA carboxylase (NCBI ptt file) | 44, 91 |
| CAC3577 | acp | Acyl Carrier Protein, ACP (NCBI ptt file) | 91, 225 |
| CAC3668 | CAC3668 | MDR-type permease (NCBI ptt file) | 82, 251 |
Gene Page Help
Network Tab
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
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Regulation Tab
Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.
Motifs Tab
Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Functions Tab
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
Help Tab
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CircVis
Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
- 4. Interactions between source and target genes for a particular module
- 5. Module(s) that source gene and target genes belong to
- 6. Visualisation legend
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