Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU2310

metallo-beta-lactamase family protein

CircVis
Functional Annotations (2)
Function System
Zn-dependent hydrolases, including glyoxylases cog/ cog
hydrolase activity go/ molecular_function
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU2310
(Mouseover regulator name to see its description)

DVU2310 is regulated by 25 influences and regulates 0 modules.
Regulators for DVU2310 (25)
Regulator Module Operator
DVU0813
DVU0230
158 combiner
DVU0936 158 tf
DVU1628
DVU0813
158 combiner
DVU1690 158 tf
DVU1788 158 tf
DVU1788
DVU2690
158 combiner
DVU2086
DVU0744
158 combiner
DVU2086
DVU2909
158 combiner
DVU2547 158 tf
DVU2547
DVU1788
158 combiner
DVU2547
DVU2086
158 combiner
DVU3255 158 tf
DVUA0151
DVU1788
158 combiner
DVU0813 104 tf
DVU0813
DVU0230
104 combiner
DVU1628
DVU0813
104 combiner
DVU1788 104 tf
DVU2086 104 tf
DVU2547
DVU1788
104 combiner
DVU2547
DVU2086
104 combiner
DVU2567
DVU0813
104 combiner
DVU2802
DVU1340
104 combiner
DVU2819
DVU0813
104 combiner
DVU2953
DVU0813
104 combiner
DVU3255 104 tf

Warning: DVU2310 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
201 1.40e+02 t.CCA...acAaGGAGaa
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RegPredict
202 9.30e+02 TTGATGcCgtcA
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RegPredict
301 2.70e+03 tCCtGTTG
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RegPredict
302 2.90e+03 gATcAcGCc.CaCgtCaacGAtGc
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU2310

DVU2310 is enriched for 2 functions in 3 categories.
Enrichment Table (2)
Function System
Zn-dependent hydrolases, including glyoxylases cog/ cog
hydrolase activity go/ molecular_function
Module neighborhood information for DVU2310

DVU2310 has total of 24 gene neighbors in modules 104, 158
Gene neighbors (24)
Gene Common Name Description Module membership
DVU0241 hypothetical protein DVU0241 104, 114
DVU0242 SecC motif-containing protein 114, 158
DVU0758 hypothetical protein DVU0758 120, 158
DVU0811 dnaK molecular chaperone DnaK 104, 218
DVU0857 radical SAM domain-containing protein 158, 218
DVU0865 membrane-associated zinc metalloprotease 158, 227
DVU0994 hypothetical protein DVU0994 158, 218
DVU1267 hypothetical protein DVU1267 158, 227
DVU1278 ftsH cell division protein FtsH 120, 158
DVU1336 clpX ATP-dependent protease ATP-binding subunit ClpX 120, 158
DVU1337 lon ATP-dependent protease La 114, 158
DVU1430 M16 family peptidase 104, 114
DVU1468 peptidase/PDZ domain-containing protein 104, 218
DVU1602 clpA ATP-dependent Clp protease, ATP-binding subunit ClpA 158, 193
DVU1874 clpB ATP-dependent Clp protease, ATP-binding subunit ClpB 4, 158
DVU1976 groEL chaperonin GroEL 104, 218
DVU1977 groES co-chaperonin GroES 104, 218
DVU2078 cheB-2 protein-glutamate methylesterase CheB 104, 218
DVU2079 sensory box histidine kinase 104, 218
DVU2310 metallo-beta-lactamase family protein 104, 158
DVU2441 HSP20 family protein 104, 114
DVU2442 HSP20 family protein 104, 114
DVU2470 membrane protein 158, 194
DVU2643 htpG heat shock protein 90 104, 218
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU2310
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend