Organism : Halobacterium salinarum NRC-1 | Module List :
VNG1149Cm
metallo-beta-lactamase superfamily hydrolase
Functional Annotations (2)
Function | System |
---|---|
Predicted hydrolase of the metallo-beta-lactamase superfamily | cog/ cog |
hydrolase activity | go/ molecular_function |
Regulation information for VNG1149Cm
(Mouseover regulator name to see its description)
Regulator | Module | Operator |
---|---|---|
VNG0101G | 23 | tf |
VNG1383G | 23 | tf |
VNG2661G VNG1029C |
23 | combiner |
VNG6143H | 23 | tf |
VNG0040C | 2 | tf |
VNG0101G VNG2163H |
2 | combiner |
VNG0194H | 2 | tf |
VNG0258H | 2 | tf |
VNG1836G | 2 | tf |
VNG2243G | 2 | tf |
VNG2661G VNG1029C |
2 | combiner |
VNG2661G VNG1123G |
2 | combiner |
VNG0040C VNG0293H |
16 | combiner |
VNG0101G VNG0320H |
16 | combiner |
VNG0101G VNG2163H |
16 | combiner |
VNG1836G | 16 | tf |
VNG2661G VNG1029C |
16 | combiner |
VNG0101G | 33 | tf |
VNG1496G | 33 | tf |
VNG6143H | 33 | tf |
Motif information (de novo identified motifs for modules)
There are 8 motifs predicted.
Motif Id | e-value | Consensus | Motif Logo |
---|---|---|---|
983 | 6.60e+00 | aAaaTcAAAacctaTaA.T | |
984 | 1.10e+03 | a.gaac.ccGcaAc.accttga.g | |
1011 | 2.80e-04 | caatttataggtTttcAcctt | |
1012 | 1.20e+01 | AaaagGGtTttcgTATcgccGT | |
1023 | 1.00e+03 | GaTtcaaAAgcaTaGa | |
1024 | 2.90e+03 | gTAAaA | |
1043 | 1.70e+00 | GaggacGc.gTCGAa | |
1044 | 1.70e+03 | cgtcgaC.AgctcGAcg.CgaGaa |
Functional Enrichment for VNG1149Cm
Function | System |
---|---|
Predicted hydrolase of the metallo-beta-lactamase superfamily | cog/ cog |
hydrolase activity | go/ molecular_function |
Module neighborhood information for VNG1149Cm
Gene | Common Name | Description | Module membership |
---|---|---|---|
VNG0013C | hypothetical protein VNG0013C | 2, 263 | |
VNG0166G | psmB | proteasome subunit alpha | 2, 275 |
VNG0192G | ftsZ2 | cell division protein FtsZ | 2, 3, 7, 12, 16, 49, 50, 71, 78, 79, 123 |
VNG0194H | hypothetical protein VNG0194H | 3, 7, 12, 16, 50, 79, 123 | |
VNG0207H | hypothetical protein VNG0207H | 2, 3, 7, 12, 16, 49, 67, 71, 78, 79, 113, 123 | |
VNG0208H | hypothetical protein VNG0208H | 2, 3, 7, 12, 16, 24, 29, 49, 67, 71, 78, 79, 113, 123 | |
VNG0209H | hypothetical protein VNG0209H | 2, 3, 7, 12, 16, 24, 29, 49, 67, 71, 78, 79, 113, 123 | |
VNG0234C | hypothetical protein VNG0234C | 2, 16 | |
VNG0258H | hypothetical protein VNG0258H | 3, 12, 16, 49, 79, 100, 109, 150 | |
VNG0259G | ipp | inorganic pyrophosphatase | 7, 12, 16, 79, 109 |
VNG0261H | hypothetical protein VNG0261H | 7, 12, 16, 25, 49, 50, 55, 79, 109, 113 | |
VNG0524G | yurY | ABC transporter ATP-binding protein | 2, 3, 7, 12, 16, 71, 113, 225 |
VNG0527C | hypothetical protein VNG0527C | 2, 3, 7, 12, 16, 71, 78, 79, 113, 123, 225 | |
VNG0548C | H/ACA RNA-protein complex component Nop10p | 1, 10, 33, 39, 66, 82, 99, 137, 161, 180 | |
VNG0549G | eif2a | translation initiation factor IF-2 subunit alpha | 10, 33, 66, 82, 99, 137, 180 |
VNG0550G | rps27e | 30S ribosomal protein S27e | 1, 10, 33, 39, 66, 82, 99, 137, 161, 165, 180 |
VNG0551G | rpl44e | 50S ribosomal protein L44E | 1, 10, 33, 39, 66, 82, 99, 137, 161, 180 |
VNG0582C | hypothetical protein VNG0582C | 16, 283 | |
VNG0584H | hypothetical protein VNG0584H | 2, 16, 24 | |
VNG0585H | hypothetical protein VNG0585H | 2, 16, 24 | |
VNG0620G | edp | proteinase IV-like protein | 2, 16 |
VNG0635G | nolB | NADH dehydrogenase/oxidoreductase-like protein | 2, 16, 19, 24, 29, 199 |
VNG0637G | ndhG5 | NADH dehydrogenase/oxidoreductase | 2, 16, 19, 24, 29 |
VNG0640G | nolD | NADH dehydrogenase/oxidoreductase-like protein | 2, 3, 16, 19, 24, 29, 45, 123 |
VNG0642C | hypothetical protein VNG0642C | 2, 24, 29, 45 | |
VNG0771G | aldY2 | AldY2 | 16, 123 |
VNG0789C | hypothetical protein VNG0789C | 10, 33, 99 | |
VNG0790G | rps15p | 30S ribosomal protein S15P | 10, 33, 99, 161 |
VNG0955G | fapE | flagella-like protein E | 7, 16, 25, 50, 100, 291 |
VNG0960G | flaB1 | flagellin B1 | 2, 3, 7, 12, 16, 49, 78, 79, 100, 113, 123 |
VNG0961G | flaB2 | flagellin B2 | 2, 3, 7, 12, 16, 49, 78, 79, 100, 113, 123, 291 |
VNG0962G | flaB3 | flagellin B3 | 2, 3, 7, 12, 16, 49, 78, 100, 113, 123 |
VNG1132G | rps13p | 30S ribosomal protein S13P | 1, 10, 33, 39, 66, 82, 137, 161, 165, 180 |
VNG1133G | rps4p | 30S ribosomal protein S4P | 1, 10, 33, 39, 66, 82, 99, 137, 161, 165, 180 |
VNG1134G | rps11p | 30S ribosomal protein S11P | 1, 10, 33, 39, 66, 82, 99, 137, 161, 165, 180 |
VNG1137G | rpl18e | 50S ribosomal protein L18e | 1, 10, 33, 39, 66, 82, 99, 137, 161, 165, 180 |
VNG1138G | rpl13p | 50S ribosomal protein L13P | 1, 10, 33, 39, 66, 82, 99, 137, 161, 165, 180 |
VNG1140G | rpoN | DNA-directed RNA polymerase subunit N | 1, 10, 33, 39, 66, 82, 99, 137, 161, 165, 180 |
VNG1141G | rpoK | DNA-directed RNA polymerase subunit K | 1, 10, 33, 39, 66, 82, 99, 137, 161, 165, 180 |
VNG1149Cm | metallo-beta-lactamase superfamily hydrolase | 2, 16, 23, 33 | |
VNG1150G | idsA | IdsA | 33 |
VNG1158G | rps28e | 30S ribosomal protein S28e | 23, 283 |
VNG1160G | ndk | nucleoside diphosphate kinase | 23, 283 |
VNG1169C | hypothetical protein VNG1169C | 23, 66, 82, 137, 161, 165, 180 | |
VNG1170G | rpl21e | 50S ribosomal protein L21e | 23, 66, 82, 137, 161, 165 |
VNG1292H | hypothetical protein VNG1292H | 24, 33 | |
VNG1294G | slyD | peptidyl-prolyl cis-trans isomerase | 23, 67, 184 |
VNG1306G | sdhA | hypothetical protein VNG1306G | 2, 3, 12, 16, 78, 79, 90, 100 |
VNG1308G | sdhB | hypothetical protein VNG1308G | 2, 278 |
VNG1310G | sdhC | hypothetical protein VNG1310G | 2, 24, 236 |
VNG1542G | sucD | hypothetical protein VNG1542G | 33, 45, 67, 114, 124 |
VNG1689G | rpl3p | 50S ribosomal protein L3P | 1, 10, 23, 39, 66, 82, 99, 137, 180 |
VNG1691G | rplW | 50S ribosomal protein L23P | 1, 10, 23, 33, 39, 66, 82, 99, 137, 161, 165, 180 |
VNG1695G | rpl22p | 50S ribosomal protein L22P | 1, 10, 23, 33, 39, 66, 82, 99, 137, 161, 165, 180 |
VNG1697G | rps3p | 30S ribosomal protein S3P | 1, 10, 23, 33, 39, 66, 82, 99, 137, 165, 180 |
VNG1699C | ribonuclease P protein component 1 | 1, 10, 23, 39, 99, 180, 227 | |
VNG1701G | rpl14p | 50S ribosomal protein L14P | 1, 10, 23, 137, 221 |
VNG1702G | rpl24p | 50S ribosomal protein L24P | 1, 10, 23, 39, 66, 82, 99, 137, 165 |
VNG1705G | rpl5p | 50S ribosomal protein L5P | 1, 10, 23, 39, 99, 180 |
VNG1706G | rps14P | 30S ribosomal protein S14P | 10, 23, 221 |
VNG1709G | rpl6p | 50S ribosomal protein L6P | 1, 10, 23, 39, 66, 99, 137, 165, 180 |
VNG1713G | rpl19e | 50S ribosomal protein L19e | 1, 10, 23, 33, 39, 66, 99, 137, 180 |
VNG1718G | rpl15p | 50S ribosomal protein L15P | 1, 10, 23, 39, 99, 180 |
VNG1719G | secY | preprotein translocase subunit SecY | 1, 10, 23, 39, 99 |
VNG1768G | eif5a | translation initiation factor IF-5A | 23, 24, 40, 59 |
VNG2053G | rpoE' | DNA-directed RNA polymerase subunit E' | 33, 59 |
VNG2098H | hypothetical protein VNG2098H | 33 | |
VNG2099C | hypothetical protein VNG2099C | 33, 45 | |
VNG2135G | atpD | V-type ATP synthase subunit D | 2, 16 |
VNG2139G | atpA | V-type ATP synthase subunit A | 23, 24, 33, 39, 45, 67, 114, 124, 227 |
VNG2140G | atpF | V-type ATP synthase subunit F | 33, 39, 45, 67, 114, 124, 227 |
VNG2141G | atpC | V-type ATP synthase subunit C | 23, 39, 45, 67, 114, 124, 227 |
VNG2143G | atpK | H+-transporting ATP synthase subunit K | 2, 19, 23, 24, 45, 67, 75, 114, 124, 227 |
VNG2144G | atpI | H+-transporting ATP synthase subunit I | 19, 23, 24, 45, 67, 75, 124, 227 |
VNG2146H | hypothetical protein VNG2146H | 2, 16, 19, 24, 45, 67, 124, 227 | |
VNG2151G | etfA | electron transfer flavoprotein subunit alpha | 33, 45, 61, 124 |
VNG2337C | hypothetical protein VNG2337C | 16, 29, 49, 113 | |
VNG2465C | hypothetical protein VNG2465C | 33, 184 | |
VNG2467G | rpl31e | 50S ribosomal protein L31e | 1, 33, 66, 82, 99, 137, 161, 165, 180 |
VNG2469G | rpl39e | 50S ribosomal protein L39e | 1, 33, 66, 82, 99, 137, 161, 165, 180 |
VNG2574G | can | aconitate hydratase | 23, 29 |
VNG2575G | rimI | Pab N-terminal acetyltransferase | 23 |
VNG2648G | rps10p | 30S ribosomal protein S10P | 2, 3, 16, 23, 24, 29, 40, 110 |
VNG2649G | eef1a | elongation factor 1-alpha | 2, 3, 16, 24, 29, 40, 79, 110 |
VNG2654Gm | EEF2 | elongation factor EF-2 | 2, 23, 110 |
VNG2658G | rps12P | 30S ribosomal protein S12P | 23, 39, 40, 45, 98, 110, 137 |
VNG2666G | rpoB'' | DNA-directed RNA polymerase subunit beta'' | 2, 16, 40, 98, 110 |
VNG6294G | perA | peroxidase / catalase | 23, 24, 29, 52 |
VNG6313G | nhaC3 | Na+/H+ antiporter | 2, 3, 12, 16, 50, 113 |
Gene Page Help
Network Tab
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.
Regulation Tab
Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.
Motifs Tab
Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Functions Tab
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
Help Tab
This help page. More general help can be accessed by clicking help menu in the main navigation bar.
CircVis
Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
- 4. Interactions between source and target genes for a particular module
- 5. Module(s) that source gene and target genes belong to
- 6. Visualisation legend
Social Tab
Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.
Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.
In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.