Organism : Clostridium acetobutylicum | Module List :
Chemotaxis protein CheW (NCBI ptt file)
Functional Annotations (5)
|Chemotaxis signal transduction protein||cog/ cog|
|signal transducer activity||go/ molecular_function|
|signal transduction||go/ biological_process|
Regulation information for CAC2224(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for CAC2224
Module neighborhood information for CAC2224
|Gene||Common Name||Description||Module membership|
|CAC0004||recF||RecF, ABC family ATPase (NCBI ptt file)||26, 272|
|CAC0568||asd||Aspartate semialdehyde dehydrogenase (gene asd) (NCBI ptt file)||26, 258|
|CAC0915||CAC0915||Endoglucanase A precursor (endo-1,4-beta-glucanase) (cellulase A), secreted; dockerin domain (NCBI ptt file)||26, 312|
|CAC1089||CAC1089||Serine kinase/phosphatase HPr (NCBI ptt file)||26, 159|
|CAC1162||CAC1162||Hypothetical protein, CF-11 family (NCBI ptt file)||26, 328|
|CAC1166||CAC1166||Hypothetical protein (NCBI ptt file)||26, 328|
|CAC1228||cisA||Site-specific DNA recombinase (NCBI ptt file)||26, 53|
|CAC1452||CAC1452||MDR-type permease (NCBI ptt file)||26, 53|
|CAC1526||CAC1526||Amidase, related to GSP of E.coli (NCBI ptt file)||26, 301|
|CAC1527||CAC1527||Spore germination protein GerKB (NCBI ptt file)||26, 183|
|CAC1605||arbA||Ketopantoate reductase (NCBI ptt file)||26, 298|
|CAC1844||CAC1844||Hypothetical protein (NCBI ptt file)||26, 123|
|CAC1861||CAC1861||Fragment flavodoxin oxidoreductase (NCBI ptt file)||26, 244|
|CAC2056||CAC2056||Hypothetical protein (NCBI ptt file)||26, 359|
|CAC2114||CAC2114||Predicted pseudouridylate synthase, YLYB B.subtilis ortholog (NCBI ptt file)||26, 270|
|CAC2155||CAC2155||Hypothetical protein (NCBI ptt file)||192, 339|
|CAC2189||CAC2189||Carbamoylphosphate synthase large subunit, short form (NCBI ptt file)||26, 119|
|CAC2204||CAC2204||Hypothetical protein (NCBI ptt file)||192, 339|
|CAC2205||fliD||Flagellar hook-associated protein FliD (NCBI ptt file)||192, 339|
|CAC2206||fliS||Flagellar protein FliS (NCBI ptt file)||192, 339|
|CAC2208||CAC2208||Flagellin family protein, YVYC B.subtilis ortholog (NCBI ptt file)||192, 339|
|CAC2209||csrA||Carbon storage regulator, csrA (NCBI ptt file)||192, 339|
|CAC2210||CAC2210||Uncharacterized protein, YVIF B.subtilis homolog (NCBI ptt file)||192, 339|
|CAC2211||flgL||Flagellin (NCBI ptt file)||192, 339|
|CAC2212||FlgK||Flagellar hook-associated protein FlgK (NCBI ptt file)||192, 339|
|CAC2216||FliM||Flagellar switch protein FliM (NCBI ptt file)||192, 339|
|CAC2217||cheW||Chemotaxis signal transduction protein CheW (NCBI ptt file)||192, 339|
|CAC2219||cheC||Chemotaxis protein CheC (NCBI ptt file)||192, 339|
|CAC2220||cheA||Chemotaxis histidine kinase, CheA (contains CheW-like adaptor domain) (NCBI ptt file)||192, 339|
|CAC2221||cheR||Chemotaxis protein methyltransferase, cheR (NCBI ptt file)||192, 339|
|CAC2222||cheB||Chemotaxis protein CheB, (CheY-like receiver domain and methylesterase domain) (NCBI ptt file)||192, 339|
|CAC2223||cheD||Chemotaxis protein CheD (NCBI ptt file)||192, 339|
|CAC2224||cheW||Chemotaxis protein CheW (NCBI ptt file)||26, 339|
|CAC2225||CAC2225||Uncharacterized conserved protein (NCBI ptt file)||316, 339|
|CAC2284||ruvB||Holliday junction specific DNA helicase, subunit ruvB (NCBI ptt file)||26, 229|
|CAC2333||spsI||DTDP-glucose pyrophosphorylase (NCBI ptt file)||26, 172|
|CAC2489||CAC2489||Predicted membrane protein (NCBI ptt file)||11, 26|
|CAC2655||CAC2655||Uncharacterized membrane-associated protein, DedA family (NCBI ptt file)||26, 359|
|CAC2715||CAC2715||Hypothetical protein (NCBI ptt file)||26, 53|
|CAC2743||CAC2743||Predicted permease, YXIO B.subtilis ortholog (NCBI ptt file)||26, 240|
|CAC2762||CAC2762||Polyferredoxin (NCBI ptt file)||26, 150|
|CAC3479||CAC3479||Hypothetical protein (NCBI ptt file)||26, 68|
|CAC3554||CAC3554||Siderophore/Surfactin synthetase related protein (NCBI ptt file)||26, 208|
|CAC3609||CAC3609||ABC-type MDR transport system, permease component (NCBI ptt file)||26, 150|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
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