Module 166 Residual: 0.50

Title Bicluster Model Residual Score
bicluster_0166 v02 0.50 -32.44
Displaying 1 - 14 of 14
Rv1129c Transcriptional regulator, XRE family

Details for Rv1129c - Transcriptional regulator, XRE family

GO Terms: GO:0052572

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.35 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1129c

Tuberculist Genomic Region

Rv1130 2-methylcitrate dehydratase (EC 4.2.1.79)

Details for Rv1130 - 2-methylcitrate dehydratase (EC 4.2.1.79)

GO Terms: GO:0047547, GO:0001101, GO:0005829, GO:0019629, GO:0019679, GO:0047547

PATRIC Pathways: Propanoate metabolism

Essentiality: Griffin Essential: 0.82 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1130

Tuberculist Genomic Region

Rv1131 2-methylcitrate synthase (EC 2.3.3.5)

Details for Rv1131 - 2-methylcitrate synthase (EC 2.3.3.5)

GO Terms: GO:0050440, GO:0001101, GO:0019629, GO:0019679, GO:0050440, GO:0052572

PATRIC Pathways: Propanoate metabolism

Essentiality: Griffin Essential: 0.66 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1131

Tuberculist Genomic Region

Rv3529c

Details for Rv3529c -

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.56 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3529c

Tuberculist Genomic Region

Rv3530c Short-chain dehydrogenase/reductase SDR

Details for Rv3530c - Short-chain dehydrogenase/reductase SDR

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.07 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3530c

Tuberculist Genomic Region

Rv3531c

Details for Rv3531c -

GO Terms: NA

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.78 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3531c

Tuberculist Genomic Region

Rv3540c Lipid carrier protein IgrF

Details for Rv3540c - Lipid carrier protein IgrF

GO Terms: GO:0044117

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.91 | In vitro Essential: NA | In vivo Essential: 0.14

Go to Gene Page: Rv3540c

Tuberculist Genomic Region

Rv3542c Conserved protein IgrD

Details for Rv3542c - Conserved protein IgrD

GO Terms: GO:0044117

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.97 | In vitro Essential: NA | In vivo Essential: 0.11

Go to Gene Page: Rv3542c

Tuberculist Genomic Region

Rv3543c Probable acyl-CoA dehydrogenase FadE29 (EC 1.3.99.-); Acyl-CoA dehydrogenase IgrC

Details for Rv3543c - Probable acyl-CoA dehydrogenase FadE29 (EC 1.3.99.-); Acyl-CoA dehydrogenase IgrC

GO Terms: GO:0044117

PATRIC Pathways: Valine, leucine and isoleucine degradation, Caprolactam degradation, Brassinosteroid biosynthesis, Geraniol degradation, Naphthalene and anthracene degradation, Fatty acid metabolism, Benzoate degradation via hydroxylation

Essentiality: Griffin Essential: 0.24 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3543c

Tuberculist Genomic Region

Rv3544c Probable acyl-CoA dehydrogenase FadE28 (EC 1.3.99.-); Acyl-CoA dehydrogenase IgrB

Details for Rv3544c - Probable acyl-CoA dehydrogenase FadE28 (EC 1.3.99.-); Acyl-CoA dehydrogenase IgrB

GO Terms: GO:0004085, GO:0009268, GO:0009405, GO:0044117

PATRIC Pathways: Fatty acid metabolism, Brassinosteroid biosynthesis, Benzoate degradation via hydroxylation, Caprolactam degradation, Geraniol degradation, Valine, leucine and isoleucine degradation, Naphthalene and anthracene degradation

Essentiality: Griffin Essential: 0.87 | In vitro Essential: NA | In vivo Essential: 0.04

Go to Gene Page: Rv3544c

Tuberculist Genomic Region

Rv3545c Putative cytochrome P450 125 (EC 1.14.-.-); Putative cytochrome P450 IgrA
Rv3546 Probable acetyl-CoA acetyltransferase FadA5 (EC 2.3.1.9)

Details for Rv3546 - Probable acetyl-CoA acetyltransferase FadA5 (EC 2.3.1.9)

GO Terms: GO:0003988

PATRIC Pathways: Reductive carboxylate cycle (CO2 fixation), Lysine degradation, Butanoate metabolism, Pyruvate metabolism, Tryptophan metabolism, Terpenoid backbone biosynthesis, Fatty acid metabolism, Synthesis and degradation of ketone bodies, Glyoxylate and dicarboxylate metabolism, Valine, leucine and isoleucine degradation, Benzoate degradation via hydroxylation, Propanoate metabolism

Essentiality: Griffin Essential: 0.78 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3546

Tuberculist Genomic Region

Rv3176c Epoxide hydrolase (EC 3.3.2.9)

Details for Rv3176c - Epoxide hydrolase (EC 3.3.2.9)

GO Terms: NA

PATRIC Pathways: Metabolism of xenobiotics by cytochrome P450

Essentiality: Griffin Essential: 0.36 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv3176c

Tuberculist Genomic Region

Rv3541c Enoyl coenzyme A hydratase IgrE

Details for Rv3541c - Enoyl coenzyme A hydratase IgrE

GO Terms: GO:0044117

PATRIC Pathways: Not assigned

Essentiality: Griffin Essential: 0.12 | In vitro Essential: NA | In vivo Essential: 0.07

Go to Gene Page: Rv3541c

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 0.0000016 e-value: 0.004
Displaying 1 - 1 of 1
transcriptional regulator, AfsR/DnrI/RedD family
regulates 14 modules
Weight: 
0.20
up-regulates
Single-strand DNA binding protein
regulates 5 modules
Weight: 
0.16
up-regulates
Transcriptional regulator, MarR family
regulates 14 modules
Weight: 
0.14
up-regulates
regulates 13 modules
Weight: 
0.14
up-regulates
Arsenical resistance operon repressor
regulates 3 modules
Weight: 
0.13
up-regulates
Transcriptional regulator, AraC family
regulates 32 modules
Weight: 
0.13
up-regulates
Transcriptional regulator, TetR family
regulates 32 modules
Weight: 
-0.12
down-regulates
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
No enrichment
Displaying 1 - 13 of 13
GO:0052572 |

response to host immune response

GO:0047547 |

2-methylcitrate dehydratase activity

GO:0001101 |

response to acid

GO:0005829 |

cytosol

GO:0019629 |

propionate catabolic process, 2-methylcitrate cycle

GO:0019679 |

propionate metabolic process, methylcitrate cycle

GO:0050440 |

2-methylcitrate synthase activity

GO:0044117 |

growth of symbiont in host

GO:0004085 |

butyryl-CoA dehydrogenase activity

GO:0009268 |

response to pH

GO:0009405 |

pathogenesis

GO:0003988 |

acetyl-CoA C-acyltransferase activity