Module 399 Residual: 0.58

Title Bicluster Model Residual Score
bicluster_0399 v02 0.58 -9.22
Displaying 1 - 13 of 13
Rv1599 Histidinol dehydrogenase (EC 1.1.1.23)

Details for Rv1599 - Histidinol dehydrogenase (EC 1.1.1.23)

GO Terms: GO:0004399, GO:0040007

PATRIC Pathways: Histidine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv1599

Tuberculist Genomic Region

Rv1600 Histidinol-phosphate aminotransferase (EC 2.6.1.9)

Details for Rv1600 - Histidinol-phosphate aminotransferase (EC 2.6.1.9)

GO Terms: GO:0004400, GO:0005618, GO:0005886, GO:0040007

PATRIC Pathways: Novobiocin biosynthesis, Tyrosine metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis, Tropane, piperidine and pyridine alkaloid biosynthesis, Phenylalanine metabolism, Histidine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv1600

Tuberculist Genomic Region

Rv1601 Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)

Details for Rv1601 - Imidazoleglycerol-phosphate dehydratase (EC 4.2.1.19)

GO Terms: GO:0004424, GO:0040007

PATRIC Pathways: Histidine metabolism

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.02 | In vivo Essential: NA

Go to Gene Page: Rv1601

Tuberculist Genomic Region

Rv2540c Chorismate synthase (EC 4.2.3.5)

Details for Rv2540c - Chorismate synthase (EC 4.2.3.5)

GO Terms: GO:0004107, GO:0004107, GO:0010181, GO:0016651, GO:0040007, GO:0051287

PATRIC Pathways: Phenylalanine, tyrosine and tryptophan biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv2540c

Tuberculist Genomic Region

Rv1603 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) / Acting phosphoribosylanthranilate isomerase (EC 5.3.1.24)

Details for Rv1603 - Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (EC 5.3.1.16) / Acting phosphoribosylanthranilate isomerase (EC 5.3.1.24)

GO Terms: GO:0003949, GO:0000105, GO:0000162, GO:0040007

PATRIC Pathways: Histidine metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis

Essentiality: Griffin Essential: 0.01 | In vitro Essential: 0.09 | In vivo Essential: NA

Go to Gene Page: Rv1603

Tuberculist Genomic Region

Rv1604 Histidinol-phosphatase [alternative form] (EC 3.1.3.15)

Details for Rv1604 - Histidinol-phosphatase [alternative form] (EC 3.1.3.15)

GO Terms: GO:0004401, GO:0005886

PATRIC Pathways: Histidine metabolism

Essentiality: Griffin Essential: 0.10 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv1604

Tuberculist Genomic Region

Rv1605 Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)

Details for Rv1605 - Imidazole glycerol phosphate synthase cyclase subunit (EC 4.1.3.-)

GO Terms: GO:0000105, GO:0040007

PATRIC Pathways: Pyruvate metabolism, 1- and 2-Methylnaphthalene degradation

Essentiality: Griffin Essential: 0.03 | In vitro Essential: 0.05 | In vivo Essential: NA

Go to Gene Page: Rv1605

Tuberculist Genomic Region

Rv1606 Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19)

Details for Rv1606 - Phosphoribosyl-AMP cyclohydrolase (EC 3.5.4.19)

GO Terms: GO:0004635, GO:0040007

PATRIC Pathways: Histidine metabolism

Essentiality: Griffin Essential: 0.02 | In vitro Essential: 0.14 | In vivo Essential: NA

Go to Gene Page: Rv1606

Tuberculist Genomic Region

Rv2537c 3-dehydroquinate dehydratase II (EC 4.2.1.10)

Details for Rv2537c - 3-dehydroquinate dehydratase II (EC 4.2.1.10)

GO Terms: GO:0003855, GO:0003855, GO:0040007, GO:0051260

PATRIC Pathways: Phenylalanine, tyrosine and tryptophan biosynthesis

Essentiality: Griffin Essential: 0.03 | In vitro Essential: 0.08 | In vivo Essential: NA

Go to Gene Page: Rv2537c

Tuberculist Genomic Region

Rv2538c 3-dehydroquinate synthase (EC 4.2.3.4)

Details for Rv2538c - 3-dehydroquinate synthase (EC 4.2.3.4)

GO Terms: GO:0003856, GO:0003856, GO:0005618, GO:0005886, GO:0009073, GO:0040007

PATRIC Pathways: Phenylalanine, tyrosine and tryptophan biosynthesis

Essentiality: Griffin Essential: 0.01 | In vitro Essential: 0.11 | In vivo Essential: NA

Go to Gene Page: Rv2538c

Tuberculist Genomic Region

Rv2539c Shikimate kinase I (EC 2.7.1.71)

Details for Rv2539c - Shikimate kinase I (EC 2.7.1.71)

GO Terms: GO:0004765, GO:0004765, GO:0040007

PATRIC Pathways: Phenylalanine, tyrosine and tryptophan biosynthesis

Essentiality: Griffin Essential: 0.08 | In vitro Essential: 0.04 | In vivo Essential: NA

Go to Gene Page: Rv2539c

Tuberculist Genomic Region

Rv2580c Histidyl-tRNA synthetase (EC 6.1.1.21)

Details for Rv2580c - Histidyl-tRNA synthetase (EC 6.1.1.21)

GO Terms: GO:0004821, GO:0005618, GO:0005886, GO:0040007

PATRIC Pathways: Aminoacyl-tRNA biosynthesis

Essentiality: Griffin Essential: 0.00 | In vitro Essential: 0.10 | In vivo Essential: NA

Go to Gene Page: Rv2580c

Tuberculist Genomic Region

Rv2581c Hydroxyacylglutathione hydrolase (EC 3.1.2.6)

Details for Rv2581c - Hydroxyacylglutathione hydrolase (EC 3.1.2.6)

GO Terms: GO:0004416

PATRIC Pathways: Pyruvate metabolism

Essentiality: Griffin Essential: 0.03 | In vitro Essential: NA | In vivo Essential: NA

Go to Gene Page: Rv2581c

Tuberculist Genomic Region

Displaying 1 - 1 of 1
Motif 1 Motif 2
e-value: 570 e-value: 670
Displaying 1 - 1 of 1
Module GO Term Enrichment Descriptions
GO:0009081 branched-chain amino acid metabolic proc...
Displaying 1 - 22 of 22
GO:0004399 |

histidinol dehydrogenase activity

GO:0040007 |

growth

GO:0004400 |

histidinol-phosphate transaminase activity

GO:0005618 |

cell wall

GO:0005886 |

plasma membrane

GO:0004424 |

imidazoleglycerol-phosphate dehydratase activity

GO:0004107 |

chorismate synthase activity

GO:0010181 |

FMN binding

GO:0016651 |

oxidoreductase activity, acting on NADH or NADPH

GO:0051287 |

NAD binding

GO:0003949 |

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity

GO:0000105 |

histidine biosynthetic process

GO:0000162 |

tryptophan biosynthetic process

GO:0004401 |

histidinol-phosphatase activity

GO:0004635 |

phosphoribosyl-AMP cyclohydrolase activity

GO:0003855 |

3-dehydroquinate dehydratase activity

GO:0051260 |

protein homooligomerization

GO:0003856 |

3-dehydroquinate synthase activity

GO:0009073 |

aromatic amino acid family biosynthetic process

GO:0004765 |

shikimate kinase activity

GO:0004821 |

histidine-tRNA ligase activity

GO:0004416 |

hydroxyacylglutathione hydrolase activity