Rv1447c Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1447c zwf2 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) CDS 1625418 1626962 - 1 545 514 FALSE

Rv1447c (Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49)) is predicted to be co-regulated in modules bicluster_0444 with residual 0.53 and bicluster_0496 with residual 0.57.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 230.00 and 23,000.00 for bicluster_0444 and 0.00 and 0.00 for bicluster_0496 respectively.

These modules are enriched for following go terms: cellular component organization, cellular component biogenesis, cellular component organization or bioge... sulfur compound metabolic process.

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0444
e.value: 
230
Motif Bicluster: 
e.value: 
23000
Motif Bicluster: 
0.53
bicluster_0496
e.value: 
2.9e-38
Motif Bicluster: 
e.value: 
6.4e-27
Motif Bicluster: 
0.57
Product (LegacyBRC) Product (RefSeq)
Glucose-6-phosphate 1-dehydrogenase glucose-6-phosphate 1-dehydrogenase
Operon # Operon
966 Rv1447c - Rv1448c - Rv1449c
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Glucose-6-phosphate dehydrogenase Glutathione metabolism, Pentose phosphate pathway
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Pentose phosphate pathway

19
Total items in this category:  

KEGG

Glutathione metabolism

14
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  

KEGG

Biosynthesis of secondary metabolites

326
Total items in this category:  

KEGG

Microbial metabolism in diverse environments

296
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608585 NP_215963.1 Run
GO:0004345

glucose-6-phosphate dehydrogenase activity

glucose-6-phosphate dehydrogenase activity

Details: 
Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.
GO Category: 
molecular_function
2
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.310000 0.90

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.