Rv1448c Transaldolase (EC 2.2.1.2)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1448c tal Transaldolase (EC 2.2.1.2) CDS 1626959 1628080 - 1 122 373 FALSE

Rv1448c (Transaldolase (EC 2.2.1.2)) is predicted to be co-regulated in modules bicluster_0010 with residual 0.32 and bicluster_0444 with residual 0.53.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 5,300.00 and 4,200.00 for bicluster_0010 and 230.00 and 23,000.00 for bicluster_0444 respectively.

These modules are enriched for following go terms: sedoheptulose-7-phosphate:D-glyceraldehy..., tRNA nucleotidyltransferase activity cellular component organization, cellular component biogenesis, cellular component organization or bioge....

This gene is found to be non-essential for growth on cholesterol.

Mutant available?: Yes

Last update: 10/16/2017 - 11:16
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-15011 MT1495 1156
Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0010
e.value: 
5300
Motif Bicluster: 
e.value: 
4200
Motif Bicluster: 
0.32
bicluster_0444
e.value: 
230
Motif Bicluster: 
e.value: 
23000
Motif Bicluster: 
0.53
Product (LegacyBRC) Product (RefSeq)
Transaldolase transaldolase
Operon # Operon
966 Rv1447c - Rv1448c - Rv1449c
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Transaldolase Pentose phosphate pathway
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Pentose phosphate pathway

19
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  

KEGG

Biosynthesis of secondary metabolites

326
Total items in this category:  

KEGG

Microbial metabolism in diverse environments

296
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15608586 NP_215964.1 Run
GO:0004801

sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity

sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity

Details: 
Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.
GO Category: 
molecular_function
2
Total items in this category:  
GO:0005576

extracellular region

extracellular region

Details: 
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO Category: 
cellular_component
272
Total items in this category:  
GO:0005829

cytosol

cytosol

Details: 
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO Category: 
cellular_component
371
Total items in this category:  
GO:0040007

growth

growth

Details: 
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
biological_process
621
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.170000 0.60

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.