Rv1844c 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1844c gnd1 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) CDS 2093731 2095188 - 1 458 485 FALSE

Rv1844c (6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)) is predicted to be co-regulated in modules bicluster_0289 with residual 0.53 and bicluster_0414 with residual 0.45.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.03 for bicluster_0289 and 65.00 and 550.00 for bicluster_0414 respectively.

These modules are enriched for following go terms: oxidoreductase activity, acting on the C..., oxidoreductase activity, acting on CH-OH... .

This gene is found to be non-essential for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0289
e.value: 
0.000000000044
Motif Bicluster: 
e.value: 
0.031
Motif Bicluster: 
0.53
bicluster_0414
e.value: 
65
Motif Bicluster: 
e.value: 
550
Motif Bicluster: 
0.45
Product (LegacyBRC) Product (RefSeq)
6-phosphogluconate dehydrogenase decarboxylating 6-phosphogluconate dehydrogenase
Operon # Operon
1211 Rv1843c - Rv1844c - Rv1845c - Rv1846c
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Pentose phosphate pathway

19
Total items in this category:  

KEGG

Glutathione metabolism

14
Total items in this category:  

KEGG

Metabolic pathways

601
Total items in this category:  

KEGG

Biosynthesis of secondary metabolites

326
Total items in this category:  

KEGG

Microbial metabolism in diverse environments

296
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
57116925 YP_177848.1 Run
GO:0004616

phosphogluconate dehydrogenase (decarboxylating) activity

phosphogluconate dehydrogenase (decarboxylating) activity

Details: 
Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+.
GO Category: 
molecular_function
2
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
Cholesterol Essentiality t-test p-value Cholesterol/Glycerol Ratio
non-essential 0.980000 3.20

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.