Rv2072c Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)
|Symbol||Product||Feature Type||Start||End||Strand||Length||AA Length||is TF|
|Rv2072c||cobL||Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [...||CDS||2328974||2330146||-||1 173||390||FALSE|
Rv2072c (Cobalt-precorrin-6y C5-methyltransferase (EC 2.1.1.-) / Cobalt-precorrin-6y C15-methyltransferase [decarboxylating] (EC 2.1.1.-)) is predicted to be co-regulated in modules bicluster_0057 with residual 0.63 and bicluster_0497 with residual 0.53.
This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.02 for bicluster_0057 and 310.00 and 800.00 for bicluster_0497 respectively.
These modules are enriched for following go terms: tetrapyrrole metabolic process, tetrapyrrole biosynthetic process, vitamin metabolic process, water-soluble vitamin metabolic process, vitamin biosynthetic process, water-soluble vitamin biosynthetic proce... 3-hydroxyacyl-CoA dehydrogenase activity.
This gene is found to be for growth on cholesterol.
Mutant available?: Yes
|Product (LegacyBRC)||Product (RefSeq)|
|Precorrin-6Y C-methyltransferase [decarboxylating]||precorrin-6y methyltransferase CobL|
|BioCyc Gene Page||Cellular Overview Map|
reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.