Rv2382c Malonyl CoA-acyl carrier protein transacylase (EC

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2382c mbtC Malonyl CoA-acyl carrier protein transacylase (EC CDS 2670269 2671603 - 1 335 444 FALSE

Rv2382c (Malonyl CoA-acyl carrier protein transacylase (EC is predicted to be co-regulated in modules bicluster_0502 with residual 0.52 and bicluster_0525 with residual 0.52.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 1.20 for bicluster_0502 and 0.00 and 5.20 for bicluster_0525 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

BASS Score Re-Annotated Start Tuberculist Annotated Start
-0.139 2671609 2671603
Product (LegacyBRC) Product (RefSeq)
POLYKETIDE SYNTHETASE MBTC [POLYKETIDE SYNTHASE] polyketide synthetase MBTC (polyketide synthase)
Operon # Operon
1571 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


[Acyl-carrier-protein] S-malonyltransferase Fatty acid biosynthesis
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


Biosynthesis of siderophore group nonribosomal peptides

Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15609519 NP_216898.1 Run

[acyl-carrier-protein] S-malonyltransferase activity

[acyl-carrier-protein] S-malonyltransferase activity

Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein].
GO Category: 
Total items in this category:  



The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.270000 0.30

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: