Rv3570c POSSIBLE OXIDOREDUCTASE

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3570c hsaA POSSIBLE OXIDOREDUCTASE CDS 4011086 4012270 - 1 185 394 FALSE

Rv3570c (POSSIBLE OXIDOREDUCTASE) is predicted to be co-regulated in modules bicluster_0200 with residual 0.45 and bicluster_0331 with residual 0.41.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.16 for bicluster_0200 and 0.00 and 0.00 for bicluster_0331 respectively.

These modules are enriched for following go terms: coenzyme binding, oxidoreductase activity primary metabolic process, cellular metabolic process, cellular process, organic substance metabolic process, cell, cell part, large ribosomal subunit, small ribosomal subunit.

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 8 of 8
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulator, TetR family
No 30 -0.12 0.99889 Primary.TSS
Repressed -2 -1.31 2.18e-17 Primary.TSS
transcriptional regulator, ArsR family
No -6 0.24 0.0678133 Primary.TSS
HTH-type transcriptional regulator
No 1 -0.05 0.863516 Primary.TSS
Transcriptional regulator, TetR family
Induced 62 2.24 5.77e-37 Primary.TSS
Histone protein Lsr2
No 28 0.19 0.554718 Primary.TSS
Transcriptional regulator kstR (Rv3574), TetR family
Repressed 45 -3.73 0 Primary.TSS
DNA-binding response regulator TrcR
No 37 -0.21 0.624175 Primary.TSS
Motif 1 Motif 2 Residual
bicluster_0200
e.value: 
8.3e-28
Motif Bicluster: 
e.value: 
0.16
Motif Bicluster: 
0.45
bicluster_0331
e.value: 
0.0000000081
Motif Bicluster: 
e.value: 
0.00082
Motif Bicluster: 
0.41
Product (LegacyBRC) Product (RefSeq)
POSSIBLE OXIDOREDUCTASE oxidoreductase
Operon # Operon
2325 - - - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15610706 NP_218087.1 Run
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0044117

growth of symbiont in host

growth of symbiont in host

Details: 
The increase in size or mass of an organism, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO Category: 
biological_process
36
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.000000 0.07

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: