Rv3917c Chromosome (plasmid) partitioning protein ParB / Stage 0 sporulation protein J

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3917c parB Chromosome (plasmid) partitioning protein ParB / Stage 0 sporulation protein J CDS 4405457 4406491 - 1 035 344 FALSE

Rv3917c (Chromosome (plasmid) partitioning protein ParB / Stage 0 sporulation protein J) is predicted to be co-regulated in modules bicluster_0224 with residual 0.55 and bicluster_0397 with residual 0.58.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 480.00 and 27.00 for bicluster_0224 and 0.00 and 0.00 for bicluster_0397 respectively.

These modules are enriched for following go terms: regulation of cellular process, regulation of biological process, biological regulation nitrogen compound metabolic process, carbon-oxygen lyase activity.

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 3 of 3
ChipSeq TF Differential Expression Distance Expression pvalue Type
Transcriptional regulator, ArsR family
Repressed 26 -0.68 0.000546682 Internal.TSS
ESX-1 secreted protein regulator EspR
No 48 -0.07 0.829262 Internal.TSS
Transcriptional regulator, IclR family
No 3 0.06 0.94838 Internal.TSS
Motif 1 Motif 2 Residual
bicluster_0224
e.value: 
480
Motif Bicluster: 
e.value: 
27
Motif Bicluster: 
0.55
bicluster_0397
e.value: 
0.000000000016
Motif Bicluster: 
e.value: 
0.000063
Motif Bicluster: 
0.58
Product (LegacyBRC) Product (RefSeq)
Probable chromosome-partitioning protein parB chromosome partitioning protein ParB
Operon # Operon
2555 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
57117170 NP_218435.2 Run
GO:0008150

biological_process

biological_process

Details: 
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO Category: 
biological_process
66
Total items in this category:  
GO:0005576

extracellular region

extracellular region

Details: 
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO Category: 
cellular_component
272
Total items in this category:  
GO:0005694

chromosome

chromosome

Details: 
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
GO Category: 
cellular_component
4
Total items in this category:  
GO:0005886

plasma membrane

plasma membrane

Details: 
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO Category: 
cellular_component
1284
Total items in this category:  
GO:0040007

growth

growth

Details: 
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
biological_process
621
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: