Rv3918c Chromosome (plasmid) partitioning protein ParA / Sporulation initiation inhibitor protein Soj

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv3918c parA Chromosome (plasmid) partitioning protein ParA / Sporulation initiation inhibitor protein Soj CDS 4406488 4407531 - 1 044 347 FALSE

Rv3918c (Chromosome (plasmid) partitioning protein ParA / Sporulation initiation inhibitor protein Soj) is predicted to be co-regulated in modules bicluster_0179 with residual 0.46 and bicluster_0209 with residual 0.57.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 3,700.00 and 6,300.00 for bicluster_0179 and 0.00 and 1,300.00 for bicluster_0209 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 1 of 1
ChipSeq TF Differential Expression Distance Expression pvalue Type
No results were found
Motif 1 Motif 2 Residual
bicluster_0179
e.value: 
3700
Motif Bicluster: 
e.value: 
6300
Motif Bicluster: 
0.46
bicluster_0209
e.value: 
0.0000045
Motif Bicluster: 
e.value: 
1300
Motif Bicluster: 
0.57
Product (LegacyBRC) Product (RefSeq)
PROBABLE CHROMOSOME PARTITIONING PROTEIN PARA chromosome partitioning protein ParA
Operon # Operon
2555 - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
57117171 NP_218434.2 Run
GO:0008150

biological_process

biological_process

Details: 
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO Category: 
biological_process
66
Total items in this category:  
GO:0005694

chromosome

chromosome

Details: 
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
GO Category: 
cellular_component
4
Total items in this category:  
GO:0040007

growth

growth

Details: 
The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
biological_process
621
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
NA NA

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: